Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma

In conclusion, we demonstrate targeted RNA-guided methylation of the MGMT promoter as a promising tool to overcome chemoresistance and improve the cytotoxic effect of TMZ in glioblastoma.PMID:37634280 | DOI:10.1016/j.neo.2023.100929

Source: Neoplasia - August 27, 2023 Category: Cancer & Oncology Authors: Xinyu Han Mohammed O E Abdallah Peter Breuer Fabian Stahl Yousuf Bakhit Anna-Laura Potthoff Barbara E F Pregler Matthias Schneider Andreas Waha Ullrich W üllner Bernd O Evert Source Type: research