Advanced progress of spatial metabolomics in head and neck cancer research
This article comprehensively reviews the progress of spatial metabolomics in head and neck cancer research, encompassing insights into cancer cell metabolic reprogramming. Various mass spectrometry imaging techniques, such as secondary ion mass spectrometry, stroma-assisted laser desorption/ionization, and desorption electrospray ionization, enable in situ metabolite analysis for head and neck cancer. Finally, significant emphasis is placed on the application of presently available techniques for early diagnosis, margin assessment, and prognosis of head and neck cancer.PMID:38142528 | DOI:10.1016/j.neo.2023.100958 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Huiting Zhao Chaowen Shi Wei Han Guanfa Luo Yumeng Huang Yujuan Fu Wen Lu Qingang Hu Zhengjun Shang Xihu Yang Source Type: research
Characteristics and survival of primary urothelial carcinoma of the prostate: A multi-center retrospective study of 18 cases
CONCLUSION: PUCP, a rare but highly aggressive type of prostate cancer, should be considered in men with abnormalities on MRI and normal serum PSA concentrations. Positive GATA-3, P63, and negative PSA are typical immunohistochemistry features. Radical cystectomy and systematic therapies can be effective.PMID:38142529 | DOI:10.1016/j.neo.2023.100961 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Junjie Ji Tian Liu Yu Yao Wen Liu Hao Ning Tongyu Wang Guiming Zhang Source Type: research
Advanced progress of spatial metabolomics in head and neck cancer research
This article comprehensively reviews the progress of spatial metabolomics in head and neck cancer research, encompassing insights into cancer cell metabolic reprogramming. Various mass spectrometry imaging techniques, such as secondary ion mass spectrometry, stroma-assisted laser desorption/ionization, and desorption electrospray ionization, enable in situ metabolite analysis for head and neck cancer. Finally, significant emphasis is placed on the application of presently available techniques for early diagnosis, margin assessment, and prognosis of head and neck cancer.PMID:38142528 | DOI:10.1016/j.neo.2023.100958 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Huiting Zhao Chaowen Shi Wei Han Guanfa Luo Yumeng Huang Yujuan Fu Wen Lu Qingang Hu Zhengjun Shang Xihu Yang Source Type: research
Characteristics and survival of primary urothelial carcinoma of the prostate: A multi-center retrospective study of 18 cases
CONCLUSION: PUCP, a rare but highly aggressive type of prostate cancer, should be considered in men with abnormalities on MRI and normal serum PSA concentrations. Positive GATA-3, P63, and negative PSA are typical immunohistochemistry features. Radical cystectomy and systematic therapies can be effective.PMID:38142529 | DOI:10.1016/j.neo.2023.100961 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Junjie Ji Tian Liu Yu Yao Wen Liu Hao Ning Tongyu Wang Guiming Zhang Source Type: research
Advanced progress of spatial metabolomics in head and neck cancer research
This article comprehensively reviews the progress of spatial metabolomics in head and neck cancer research, encompassing insights into cancer cell metabolic reprogramming. Various mass spectrometry imaging techniques, such as secondary ion mass spectrometry, stroma-assisted laser desorption/ionization, and desorption electrospray ionization, enable in situ metabolite analysis for head and neck cancer. Finally, significant emphasis is placed on the application of presently available techniques for early diagnosis, margin assessment, and prognosis of head and neck cancer.PMID:38142528 | DOI:10.1016/j.neo.2023.100958 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Huiting Zhao Chaowen Shi Wei Han Guanfa Luo Yumeng Huang Yujuan Fu Wen Lu Qingang Hu Zhengjun Shang Xihu Yang Source Type: research
Characteristics and survival of primary urothelial carcinoma of the prostate: A multi-center retrospective study of 18 cases
CONCLUSION: PUCP, a rare but highly aggressive type of prostate cancer, should be considered in men with abnormalities on MRI and normal serum PSA concentrations. Positive GATA-3, P63, and negative PSA are typical immunohistochemistry features. Radical cystectomy and systematic therapies can be effective.PMID:38142529 | DOI:10.1016/j.neo.2023.100961 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Junjie Ji Tian Liu Yu Yao Wen Liu Hao Ning Tongyu Wang Guiming Zhang Source Type: research
Advanced progress of spatial metabolomics in head and neck cancer research
This article comprehensively reviews the progress of spatial metabolomics in head and neck cancer research, encompassing insights into cancer cell metabolic reprogramming. Various mass spectrometry imaging techniques, such as secondary ion mass spectrometry, stroma-assisted laser desorption/ionization, and desorption electrospray ionization, enable in situ metabolite analysis for head and neck cancer. Finally, significant emphasis is placed on the application of presently available techniques for early diagnosis, margin assessment, and prognosis of head and neck cancer.PMID:38142528 | DOI:10.1016/j.neo.2023.100958 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Huiting Zhao Chaowen Shi Wei Han Guanfa Luo Yumeng Huang Yujuan Fu Wen Lu Qingang Hu Zhengjun Shang Xihu Yang Source Type: research
Characteristics and survival of primary urothelial carcinoma of the prostate: A multi-center retrospective study of 18 cases
CONCLUSION: PUCP, a rare but highly aggressive type of prostate cancer, should be considered in men with abnormalities on MRI and normal serum PSA concentrations. Positive GATA-3, P63, and negative PSA are typical immunohistochemistry features. Radical cystectomy and systematic therapies can be effective.PMID:38142529 | DOI:10.1016/j.neo.2023.100961 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Junjie Ji Tian Liu Yu Yao Wen Liu Hao Ning Tongyu Wang Guiming Zhang Source Type: research
Advanced progress of spatial metabolomics in head and neck cancer research
This article comprehensively reviews the progress of spatial metabolomics in head and neck cancer research, encompassing insights into cancer cell metabolic reprogramming. Various mass spectrometry imaging techniques, such as secondary ion mass spectrometry, stroma-assisted laser desorption/ionization, and desorption electrospray ionization, enable in situ metabolite analysis for head and neck cancer. Finally, significant emphasis is placed on the application of presently available techniques for early diagnosis, margin assessment, and prognosis of head and neck cancer.PMID:38142528 | DOI:10.1016/j.neo.2023.100958 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Huiting Zhao Chaowen Shi Wei Han Guanfa Luo Yumeng Huang Yujuan Fu Wen Lu Qingang Hu Zhengjun Shang Xihu Yang Source Type: research
Characteristics and survival of primary urothelial carcinoma of the prostate: A multi-center retrospective study of 18 cases
CONCLUSION: PUCP, a rare but highly aggressive type of prostate cancer, should be considered in men with abnormalities on MRI and normal serum PSA concentrations. Positive GATA-3, P63, and negative PSA are typical immunohistochemistry features. Radical cystectomy and systematic therapies can be effective.PMID:38142529 | DOI:10.1016/j.neo.2023.100961 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Junjie Ji Tian Liu Yu Yao Wen Liu Hao Ning Tongyu Wang Guiming Zhang Source Type: research
Advanced progress of spatial metabolomics in head and neck cancer research
This article comprehensively reviews the progress of spatial metabolomics in head and neck cancer research, encompassing insights into cancer cell metabolic reprogramming. Various mass spectrometry imaging techniques, such as secondary ion mass spectrometry, stroma-assisted laser desorption/ionization, and desorption electrospray ionization, enable in situ metabolite analysis for head and neck cancer. Finally, significant emphasis is placed on the application of presently available techniques for early diagnosis, margin assessment, and prognosis of head and neck cancer.PMID:38142528 | DOI:10.1016/j.neo.2023.100958 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Huiting Zhao Chaowen Shi Wei Han Guanfa Luo Yumeng Huang Yujuan Fu Wen Lu Qingang Hu Zhengjun Shang Xihu Yang Source Type: research
Characteristics and survival of primary urothelial carcinoma of the prostate: A multi-center retrospective study of 18 cases
CONCLUSION: PUCP, a rare but highly aggressive type of prostate cancer, should be considered in men with abnormalities on MRI and normal serum PSA concentrations. Positive GATA-3, P63, and negative PSA are typical immunohistochemistry features. Radical cystectomy and systematic therapies can be effective.PMID:38142529 | DOI:10.1016/j.neo.2023.100961 (Source: Neoplasia)
Source: Neoplasia - December 24, 2023 Category: Cancer & Oncology Authors: Junjie Ji Tian Liu Yu Yao Wen Liu Hao Ning Tongyu Wang Guiming Zhang Source Type: research
Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers
Neoplasia. 2023 Dec 21;47:100957. doi: 10.1016/j.neo.2023.100957. Online ahead of print.ABSTRACTRECQL is essential for genomic stability. Here, we evaluated RECQL in 449 pure ductal carcinomas in situ (DCIS), 152 DCIS components of mixed DCIS/invasive breast cancer (IBC) tumors, 157 IBC components of mixed DCIS/IBC and 50 normal epithelial terminal ductal lobular units (TDLUs). In 726 IBCs, CD8+, FOXP3+, IL17+, PDL1+, PD1+ T-cell infiltration (TILs) were investigated in RECQL deficient and proficient cancers. Tumor mutation burden (TMB) was evaluated in five RECQL germ-line mutation carriers with IBC by genome sequencing. ...
Source: Neoplasia - December 22, 2023 Category: Cancer & Oncology Authors: Ayat Lashen Abdulbaqi Al-Kawaz Jennie N Jeyapalan Shatha Alqahtani Ahmed Shoqafi Mashael Algethami Michael Toss Andrew R Green Nigel P Mongan Sudha Sharma Mohammad R Akbari Emad A Rakha Srinivasan Madhusudan Source Type: research
Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers
Neoplasia. 2023 Dec 21;47:100957. doi: 10.1016/j.neo.2023.100957. Online ahead of print.ABSTRACTRECQL is essential for genomic stability. Here, we evaluated RECQL in 449 pure ductal carcinomas in situ (DCIS), 152 DCIS components of mixed DCIS/invasive breast cancer (IBC) tumors, 157 IBC components of mixed DCIS/IBC and 50 normal epithelial terminal ductal lobular units (TDLUs). In 726 IBCs, CD8+, FOXP3+, IL17+, PDL1+, PD1+ T-cell infiltration (TILs) were investigated in RECQL deficient and proficient cancers. Tumor mutation burden (TMB) was evaluated in five RECQL germ-line mutation carriers with IBC by genome sequencing. ...
Source: Neoplasia - December 22, 2023 Category: Cancer & Oncology Authors: Ayat Lashen Abdulbaqi Al-Kawaz Jennie N Jeyapalan Shatha Alqahtani Ahmed Shoqafi Mashael Algethami Michael Toss Andrew R Green Nigel P Mongan Sudha Sharma Mohammad R Akbari Emad A Rakha Srinivasan Madhusudan Source Type: research
Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers
Neoplasia. 2023 Dec 21;47:100957. doi: 10.1016/j.neo.2023.100957. Online ahead of print.ABSTRACTRECQL is essential for genomic stability. Here, we evaluated RECQL in 449 pure ductal carcinomas in situ (DCIS), 152 DCIS components of mixed DCIS/invasive breast cancer (IBC) tumors, 157 IBC components of mixed DCIS/IBC and 50 normal epithelial terminal ductal lobular units (TDLUs). In 726 IBCs, CD8+, FOXP3+, IL17+, PDL1+, PD1+ T-cell infiltration (TILs) were investigated in RECQL deficient and proficient cancers. Tumor mutation burden (TMB) was evaluated in five RECQL germ-line mutation carriers with IBC by genome sequencing. ...
Source: Neoplasia - December 22, 2023 Category: Cancer & Oncology Authors: Ayat Lashen Abdulbaqi Al-Kawaz Jennie N Jeyapalan Shatha Alqahtani Ahmed Shoqafi Mashael Algethami Michael Toss Andrew R Green Nigel P Mongan Sudha Sharma Mohammad R Akbari Emad A Rakha Srinivasan Madhusudan Source Type: research
