Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research
Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research
Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research
Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research
PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
Neoplasia. 2024 Mar 14;51:100987. doi: 10.1016/j.neo.2024.100987. Online ahead of print.ABSTRACTGene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patient with advanced HGSC. We show that the fusion induces HGSC cell migration by regulating ERK1/2 and increases resistance to platinum treatment. Platinum resistance was associated with rod and ring-like cellular structure formation. These structures contained, in addition to...
Source: Neoplasia - March 15, 2024 Category: Cancer & Oncology Authors: Heidi Rausio Alejandra Cervera Vanina D Heuser Gun West Jaana Oikkonen Elena Pianfetti Marta Lovino Elisa Ficarra Pekka Taimen Johanna Hynninen Rainer Lehtonen Sampsa Hautaniemi Olli Carp én Kaisa Huhtinen Source Type: research
PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
Neoplasia. 2024 Mar 14;51:100987. doi: 10.1016/j.neo.2024.100987. Online ahead of print.ABSTRACTGene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patient with advanced HGSC. We show that the fusion induces HGSC cell migration by regulating ERK1/2 and increases resistance to platinum treatment. Platinum resistance was associated with rod and ring-like cellular structure formation. These structures contained, in addition to...
Source: Neoplasia - March 15, 2024 Category: Cancer & Oncology Authors: Heidi Rausio Alejandra Cervera Vanina D Heuser Gun West Jaana Oikkonen Elena Pianfetti Marta Lovino Elisa Ficarra Pekka Taimen Johanna Hynninen Rainer Lehtonen Sampsa Hautaniemi Olli Carp én Kaisa Huhtinen Source Type: research
Advancing glioblastoma treatment by targeting metabolism
Neoplasia. 2024 Mar 12;51:100985. doi: 10.1016/j.neo.2024.100985. Online ahead of print.ABSTRACTAlterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism reprogramming have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, it is becoming increasingly important to explore the role of internal and external factors in metabolic re...
Source: Neoplasia - March 13, 2024 Category: Cancer & Oncology Authors: Jinyi Zhao Xuemei Ma Peixian Gao Xueqi Han Pengxiang Zhao Fei Xie Mengyu Liu Source Type: research
Advancing glioblastoma treatment by targeting metabolism
Neoplasia. 2024 Mar 12;51:100985. doi: 10.1016/j.neo.2024.100985. Online ahead of print.ABSTRACTAlterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism reprogramming have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, it is becoming increasingly important to explore the role of internal and external factors in metabolic re...
Source: Neoplasia - March 13, 2024 Category: Cancer & Oncology Authors: Jinyi Zhao Xuemei Ma Peixian Gao Xueqi Han Pengxiang Zhao Fei Xie Mengyu Liu Source Type: research
ST6GAL1 is associated with poor response to chemoradiation in rectal cancer
CONCLUSION: ST6GAL1 is associated with resistance to treatment in human rectal cancer and knockdown in an organoid model abrogated resistance to apoptosis caused by chemoradiation.PMID:38467087 | DOI:10.1016/j.neo.2024.100984 (Source: Neoplasia)
Source: Neoplasia - March 11, 2024 Category: Cancer & Oncology Authors: Mary Smithson Sameer Al Diffalha Regina K Irwin Gregory Williams M Chandler McLeod Vivek Somasundaram Susan L Bellis Karin M Hardiman Source Type: research
ST6GAL1 is associated with poor response to chemoradiation in rectal cancer
CONCLUSION: ST6GAL1 is associated with resistance to treatment in human rectal cancer and knockdown in an organoid model abrogated resistance to apoptosis caused by chemoradiation.PMID:38467087 | DOI:10.1016/j.neo.2024.100984 (Source: Neoplasia)
Source: Neoplasia - March 11, 2024 Category: Cancer & Oncology Authors: Mary Smithson Sameer Al Diffalha Regina K Irwin Gregory Williams M Chandler McLeod Vivek Somasundaram Susan L Bellis Karin M Hardiman Source Type: research
ST6GAL1 is associated with poor response to chemoradiation in rectal cancer
CONCLUSION: ST6GAL1 is associated with resistance to treatment in human rectal cancer and knockdown in an organoid model abrogated resistance to apoptosis caused by chemoradiation.PMID:38467087 | DOI:10.1016/j.neo.2024.100984 (Source: Neoplasia)
Source: Neoplasia - March 11, 2024 Category: Cancer & Oncology Authors: Mary Smithson Sameer Al Diffalha Regina K Irwin Gregory Williams M Chandler McLeod Vivek Somasundaram Susan L Bellis Karin M Hardiman Source Type: research
IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis
CONCLUSION: This study indicates that IL-6 in the tumor microenvironment is essential for intercellular communication. We show that H. pylori enhances an IL-6-driven autocrine and paracrine positive feedback loop between macrophages and gastric epithelial cells, which may contribute to gastric carcinogenesis.PMID:38422751 | PMC:PMC10912637 | DOI:10.1016/j.neo.2024.100981 (Source: Neoplasia)
Source: Neoplasia - February 29, 2024 Category: Cancer & Oncology Authors: Bingting Yu Danny de Vos Xiaopei Guo SanFei Peng Wenjie Xie Maikel P Peppelenbosch Yang Fu Gwenny M Fuhler Source Type: research
IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis
CONCLUSION: This study indicates that IL-6 in the tumor microenvironment is essential for intercellular communication. We show that H. pylori enhances an IL-6-driven autocrine and paracrine positive feedback loop between macrophages and gastric epithelial cells, which may contribute to gastric carcinogenesis.PMID:38422751 | PMC:PMC10912637 | DOI:10.1016/j.neo.2024.100981 (Source: Neoplasia)
Source: Neoplasia - February 29, 2024 Category: Cancer & Oncology Authors: Bingting Yu Danny de Vos Xiaopei Guo SanFei Peng Wenjie Xie Maikel P Peppelenbosch Yang Fu Gwenny M Fuhler Source Type: research
IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis
CONCLUSION: This study indicates that IL-6 in the tumor microenvironment is essential for intercellular communication. We show that H. pylori enhances an IL-6-driven autocrine and paracrine positive feedback loop between macrophages and gastric epithelial cells, which may contribute to gastric carcinogenesis.PMID:38422751 | PMC:PMC10912637 | DOI:10.1016/j.neo.2024.100981 (Source: Neoplasia)
Source: Neoplasia - February 29, 2024 Category: Cancer & Oncology Authors: Bingting Yu Danny de Vos Xiaopei Guo SanFei Peng Wenjie Xie Maikel P Peppelenbosch Yang Fu Gwenny M Fuhler Source Type: research
IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis
CONCLUSION: This study indicates that IL-6 in the tumor microenvironment is essential for intercellular communication. We show that H. pylori enhances an IL-6-driven autocrine and paracrine positive feedback loop between macrophages and gastric epithelial cells, which may contribute to gastric carcinogenesis.PMID:38422751 | PMC:PMC10912637 | DOI:10.1016/j.neo.2024.100981 (Source: Neoplasia)
Source: Neoplasia - February 29, 2024 Category: Cancer & Oncology Authors: Bingting Yu Danny de Vos Xiaopei Guo SanFei Peng Wenjie Xie Maikel P Peppelenbosch Yang Fu Gwenny M Fuhler Source Type: research
