IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis

CONCLUSION: This study indicates that IL-6 in the tumor microenvironment is essential for intercellular communication. We show that H. pylori enhances an IL-6-driven autocrine and paracrine positive feedback loop between macrophages and gastric epithelial cells, which may contribute to gastric carcinogenesis.PMID:38422751 | PMC:PMC10912637 | DOI:10.1016/j.neo.2024.100981

Source: Neoplasia - February 29, 2024 Category: Cancer & Oncology Authors: Bingting Yu Danny de Vos Xiaopei Guo SanFei Peng Wenjie Xie Maikel P Peppelenbosch Yang Fu Gwenny M Fuhler Source Type: research