Advancing glioblastoma treatment by targeting metabolism

Neoplasia. 2024 Mar 12;51:100985. doi: 10.1016/j.neo.2024.100985. Online ahead of print.ABSTRACTAlterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism reprogramming have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, it is becoming increasingly important to explore the role of internal and external factors in metabolic regulation in order to identify more precise therapeutic targets and diagnostic markers for GBM. In this review, we define the metabolic characteristics of GBM, investigate metabolic specificities such as targetable vulnerabilities and therapeutic resistance, as well as present current efforts to target GBM metabolism to improve the standard of care.PMID:38479191 | DOI:10.1016/j.neo.2024.100985
Source: Neoplasia - Category: Cancer & Oncology Authors: Source Type: research