PI3K-CCL2-CCR2-MDSCs axis: A potential pathway for tumor Clostridia-promoted CD 8 < sup > + < /sup > T lymphocyte infiltration in bile tract cancers

CONCLUSIONS: The tumor microbiome is related to CD8+ T lymphocyte infiltration in patients with resected BTCs. The relationship between tumor Clostridia and high infiltration of CD8+ T lymphocytes might reflect decreased recruitment of myeloid-derived suppressor cells via the PI3K-CCL2-CCR2 axis.PMID:37515847 | DOI:10.1016/j.neo.2023.100920

Source: Neoplasia - July 29, 2023 Category: Cancer & Oncology Authors: Wen-Jie Ma Zheng-Hua Li Zhen-Ru Wu Fei Liu Jun-Ke Wang Yu-Jun Shi Yan-Wen Jin Fu-Yu Li Source Type: research