Meningeal inflammation as a driver of cortical grey matter pathology and clinical progression in multiple sclerosis
Nature Reviews Neurology, Published online: 03 July 2023; doi:10.1038/s41582-023-00838-7Growing evidence indicates a central role for meningeal inflammation in driving multiple sclerosis (MS) pathology. In this Review, the authors summarize current knowledge regarding structural, cellular and molecular changes to the meninges in MS and discuss the clinical and therapeutic implications. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 3, 2023 Category: Neurology Authors: Roberta Magliozzi Owain W. Howell Massimiliano Calabrese Richard Reynolds Source Type: research
Data-driven care for patients with neurodegenerative disorders
Nature Reviews Neurology, Published online: 03 July 2023; doi:10.1038/s41582-023-00828-9Data-driven approaches hold considerable promise for medical breakthroughs in the precision and cost-effectiveness of the prevention, diagnosis and treatment of neurodegenerative diseases. The scientists and health care professionals who will be responsible for providing the evidence to support these approaches must also consider the ethical challenges involved in the care of people with intellectual impairments. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 3, 2023 Category: Neurology Authors: Gunhild Waldemar Source Type: research
AI-based tools for the diagnosis and treatment of rare neurological disorders
Nature Reviews Neurology, Published online: 03 July 2023; doi:10.1038/s41582-023-00841-yArtificial intelligence-based tools have the potential to transform health care, enabling faster and more accurate diagnosis, personalized treatment plans, new therapeutic approaches and effective disease monitoring. Artificial intelligence shows particular promise for the management of rare neurological disorders by augmenting knowledge and facilitating the sharing of expertise among physicians. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 3, 2023 Category: Neurology Authors: Maria J. Molnar Viktor Molnar Source Type: research
AI and protein structure and function in neurological disease: relevance to disease management
Nature Reviews Neurology, Published online: 02 July 2023; doi:10.1038/s41582-023-00840-zArtificial intelligence has emerged as a powerful tool for predicting protein structure. This technology is now being applied to improve our understanding of protein aggregation in neurodegenerative and other neurological disorders, and could potentially improve disease management by enabling precision medicine. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 2, 2023 Category: Neurology Authors: Tiago F. Outeiro Tuane C. R. G. Vieira Source Type: research
AI and deep brain stimulation: what have we learned?
Nature Reviews Neurology, Published online: 02 July 2023; doi:10.1038/s41582-023-00836-9Deep brain stimulation (DBS) is a well-established approach for treating movement disorders such as Parkinson disease, dystonia and essential tremor. However, the outcomes are variable, and researchers are now exploring artificial intelligence-based strategies to help improve DBS procedures. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 2, 2023 Category: Neurology Authors: Patricia Limousin Harith Akram Source Type: research
How can we stop digital technologies from worsening existing health inequalities?
Nature Reviews Neurology, Published online: 01 July 2023; doi:10.1038/s41582-023-00830-1Digital technologies for data collection and remote monitoring can offer several indubitable advantages in neurological disorders. However, an equitable future for the use of digital technology in neurology will be possible only with global, collaborative and multidisciplinary planning that should be promptly prepared and implemented. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 1, 2023 Category: Neurology Authors: Elena Moro Source Type: research
Neurology beyond big data — the ninth Congress of the EAN
Nature Reviews Neurology, Published online: 01 July 2023; doi:10.1038/s41582-023-00837-8The overarching theme of the ninth Congress of the European Academy of Neurology (1–4 July 2023) is ‘neurology beyond big data’. The Congress provides an opportunity for neurologists, neuroscientists and other experts to discuss how the power of neurological data might be harnessed to advance discovery and improve patient outcomes and brain health. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 1, 2023 Category: Neurology Authors: Ulf Kallweit Anthony G. Marson Source Type: research
Myelin damage links brain ageing to amyloid-β deposition
Nature Reviews Neurology, Published online: 19 June 2023; doi:10.1038/s41582-023-00843-wLoss of myelin integrity, which occurs during ageing, promotes deposition of amyloid-β in the brain, according to new research. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 19, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Cognitive impairment in people living with HIV: consensus recommendations for a new approach
Nature Reviews Neurology, Published online: 13 June 2023; doi:10.1038/s41582-023-00813-2Current approaches to classifying cognitive impairment in people living with HIV can overestimate disease burden and lead to ambiguity around disease mechanisms. In this Consensus Statement, the International HIV-Cognition Working Group have outlined six recommendations towards a new approach, intended to better represent changes in the spectrum of HIV disease in the modern era of antiretroviral therapy. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 13, 2023 Category: Neurology Authors: Sam Nightingale Beau Ances Paola Cinque Ameet Dravid Anna J. Dreyer Magnus Gissl én John A. Joska Judith Kwasa Ana-Claire Meyer Nombeko Mpongo Noeline Nakasujja Roger Pebody Anton Pozniak Richard W. Price Christopher Sandford Deanna Saylor Kevin G. F. Th Source Type: research
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Nature Reviews Neurology, Published online: 12 June 2023; doi:10.1038/s41582-023-00822-1Astrocytes are essential for neuronal survival and function in the CNS but, under pathological conditions, they can adopt potentially harmful reactive states. This Review highlights how ‘omics’ technologies can enable the functional characterization of defined reactive astrocyte states in various pathological scenarios. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 12, 2023 Category: Neurology Authors: Rickie Patani Giles E. Hardingham Shane A. Liddelow Source Type: research
Is it time for genetic modifiers to predict prognosis in Duchenne muscular dystrophy?
Nature Reviews Neurology, Published online: 12 June 2023; doi:10.1038/s41582-023-00823-0Patients with Duchenne muscular dystrophy show clinically relevant phenotypic variability, despite sharing the same primary biochemical defect (dystrophin deficiency). In this Review, the authors provide an overview of the current evidence on Duchenne muscular dystrophy genetic modifiers that contribute to this variability. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 12, 2023 Category: Neurology Authors: Luca Bello Eric P. Hoffman Elena Pegoraro Source Type: research
α-Crystallin B autoimmunity and multiple sclerosis
Nature Reviews Neurology, Published online: 06 June 2023; doi:10.1038/s41582-023-00833-yα-Crystallin B autoimmunity and multiple sclerosis (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 6, 2023 Category: Neurology Authors: Heather Wood Source Type: research
A new drug to treat chorea in Huntington disease
Nature Reviews Neurology, Published online: 06 June 2023; doi:10.1038/s41582-023-00832-zA new drug to treat chorea in Huntington disease (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 6, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Glymphatic dysfunction detected in bvFTD
Nature Reviews Neurology, Published online: 06 June 2023; doi:10.1038/s41582-023-00834-xGlymphatic dysfunction detected in bvFTD (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 6, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Microglial transcriptional changes in AD
Nature Reviews Neurology, Published online: 06 June 2023; doi:10.1038/s41582-023-00835-wMicroglial transcriptional changes in AD (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 6, 2023 Category: Neurology Authors: Heather Wood Source Type: research
