Neural cell state shifts and fate loss in ageing and age-related diseases
Nature Reviews Neurology, Published online: 02 June 2023; doi:10.1038/s41582-023-00815-0Here, the authors offer their perspective on the roles of cell states in sustaining health and counteracting disease, and examine how cellular ageing might set the stage for pathological fate loss and neurodegeneration. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 2, 2023 Category: Neurology Authors: Larissa Traxler Raffaella Lucciola Joseph R. Herdy Jeffrey R. Jones Jerome Mertens Fred H. Gage Source Type: research
Oligomeric tau could spread through synapses in AD
Nature Reviews Neurology, Published online: 31 May 2023; doi:10.1038/s41582-023-00831-0Oligomeric tau accumulates in the synapses of people with Alzheimer disease, according to new research using post-mortem brain samples. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 31, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Cardiovascular risk factors for epilepsy and dementia
Nature Reviews Neurology, Published online: 30 May 2023; doi:10.1038/s41582-023-00826-xA new study using the UK Biobank database has shown that people with epilepsy are at an increased risk of developing dementia. The results demonstrate that this risk is multiplied in individuals who also have high cardiovascular risk, highlighting the importance of addressing modifiable cardiovascular risk factors. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 30, 2023 Category: Neurology Authors: Michele Romoli Cinzia Costa Source Type: research
Advances in the therapeutic algorithm for myasthenia gravis
Nature Reviews Neurology, Published online: 30 May 2023; doi:10.1038/s41582-023-00825-yNew biologics are rapidly opening up target-specific therapeutic opportunities for myasthenia gravis (MG) β an autoimmune disease caused by antibodies against neuromuscular junction proteins. Two recent trials have now demonstrated the efficacy and tolerability of the complement C5 inhibitor zilucoplan and the FcRn inhibitor rozanolixizumab in patients with generalized MG. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 30, 2023 Category: Neurology Authors: Marinos C. Dalakas Source Type: research
Promising results for antisense RNA therapy in mouse models of diffuse midline glioma
Nature Reviews Neurology, Published online: 30 May 2023; doi:10.1038/s41582-023-00829-8Promising results for antisense RNA therapy in mouse models of diffuse midline glioma (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 30, 2023 Category: Neurology Authors: Caroline Barranco Source Type: research
Continuous levodopa production by an artificial enzyme
Nature Reviews Neurology, Published online: 24 May 2023; doi:10.1038/s41582-023-00827-wResearchers in China have developed a functional nucleic acid-based responsive artificial enzyme that enables continuous production of levodopa in a mouse model of Parkinson disease. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 24, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Global synergistic actions to improve brain health for human development
Nature Reviews Neurology, Published online: 19 May 2023; doi:10.1038/s41582-023-00808-zIn this Perspective, Owolabi et al. propose strategies to improve brain health and address the growing global burden of neurological disorders. They present a new framework β the neurological quadrangle β which aims to provide equitable and effective surveillance, prevention, acute care and rehabilitation of neurological disorders globally. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 19, 2023 Category: Neurology Authors: Mayowa O. Owolabi Matilde Leonardi Claudio Bassetti Joke Jaarsma Tadeusz Hawrot Akintomiwa I. Makanjuola Rajinder K. Dhamija Wuwei Feng Volker Straub Jennifer Camaradou David W. Dodick Rosita Sunna Bindu Menon Claire Wright Chris Lynch Antonella Santuccio Source Type: research
Publisher Correction: Functional brain networks in the evaluation of patients with neurodegenerative disorders
Nature Reviews Neurology, Published online: 19 May 2023; doi:10.1038/s41582-023-00824-zPublisher Correction: Functional brain networks in the evaluation of patients with neurodegenerative disorders (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 19, 2023 Category: Neurology Authors: Matej Perovnik Toma ΕΎ Rus Katharina A. Schindlbeck David Eidelberg Source Type: research
Mechanisms underlying phenotypic variation in neurogenetic disorders
Nature Reviews Neurology, Published online: 18 May 2023; doi:10.1038/s41582-023-00811-4Neurological diseases associated with specific pathogenic gene variants can show considerable phenotypic variation. This Review explores the mechanisms that underlie this phenomenon, including environmental, genetic and epigenetic factors that influence the expressivity and penetrance of pathogenic variants. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 18, 2023 Category: Neurology Authors: Jean-Marc Burgunder Source Type: research
Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease
Nature Reviews Neurology, Published online: 17 May 2023; doi:10.1038/s41582-023-00809-yIn this Review, the authors discuss the ways in which single-cell and spatially resolved transcriptomics are contributing to our understanding of the pathophysiology of neurological conditions. They also discuss the limitations and possible future directions of these technologies. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 17, 2023 Category: Neurology Authors: Monika Piwecka Nikolaus Rajewsky Agnieszka Rybak-Wolf Source Type: research
Author Correction: Why functional neurological disorder is not feigning or malingering
Nature Reviews Neurology, Published online: 16 May 2023; doi:10.1038/s41582-023-00821-2Author Correction: Why functional neurological disorder is not feigning or malingering (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 16, 2023 Category: Neurology Authors: Mark J. Edwards Mahinda Yogarajah Jon Stone Source Type: research
Time trends in neuropathology give clues to dementia risk reduction
Nature Reviews Neurology, Published online: 12 May 2023; doi:10.1038/s41582-023-00812-3A new study examining trends in postmortem neuropathology results over the past 25 years provides important insights into secular trends in dementia risk. The results suggest that improvements in both cardiovascular health and cognitive reserve underlie the reduced risk. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 12, 2023 Category: Neurology Authors: Richard Merrick Fiona E. Matthews Source Type: research
Hypothalamic hormone linked to weight loss in ALS
Nature Reviews Neurology, Published online: 05 May 2023; doi:10.1038/s41582-023-00820-3A new study indicates loss of hypothalamic melanin-concentrating hormone in ALS, providing insights into the mechanisms underlying weight loss in individuals with the disease. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 5, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
New blood biomarker of refractory epilepsy
Nature Reviews Neurology, Published online: 05 May 2023; doi:10.1038/s41582-023-00819-wNew blood biomarker of refractory epilepsy (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 5, 2023 Category: Neurology Authors: Sarah Lempriere Source Type: research
The noradrenergic subtype of Parkinson disease: from animal models to clinical practice
Nature Reviews Neurology, Published online: 04 May 2023; doi:10.1038/s41582-023-00802-5Some patients with Parkinson disease (PD) present with mostly non-motor symptoms. Here, Chaudhuri et al. discuss the evidence for CNS abnormalities in noradrenergic function in these individuals. Recognition of this noradrenergic subtype of PD might ultimately lead to subtype-specific treatments and personalized medicine. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 4, 2023 Category: Neurology Authors: K. Ray Chaudhuri Valentina Leta Kirsty Bannister David J. Brooks Per Svenningsson Source Type: research
