Neuropsychological impairment in amyotrophic lateral sclerosis–frontotemporal spectrum disorder
Nature Reviews Neurology, Published online: 12 October 2023; doi:10.1038/s41582-023-00878-zThe term amyotrophic lateral sclerosis (ALS)–frontotemporal spectrum disorder encompasses a spectrum ranging from pure motor ALS to ALS with frontotemporal dementia. This Review focuses on the cognitive and behavioural impairments that are found in the mid-range of this spectrum. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - October 12, 2023 Category: Neurology Authors: Sharon Abrahams Source Type: research
Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
Nature Reviews Neurology, Published online: 10 October 2023; doi:10.1038/s41582-023-00879-yAcquired neurocognitive impairment affects 30–50% of the 38 million people living with HIV worldwide. Here, the authors provide an overview of the proposed mechanisms of HIV-associated neurocognitive impairment and describe potential and emerging therapeutics and non-pharmacological interventions. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - October 10, 2023 Category: Neurology Authors: Ronald J. Ellis Mar ía J. Marquine Marcus Kaul Jerel Adam Fields Johannes C. M. Schlachetzki Source Type: research
Vaccine shows promise in diffuse midline glioma
Nature Reviews Neurology, Published online: 09 October 2023; doi:10.1038/s41582-023-00888-xVaccine shows promise in diffuse midline glioma (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - October 9, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Prodromal psychiatric symptoms in MS
Nature Reviews Neurology, Published online: 09 October 2023; doi:10.1038/s41582-023-00887-yProdromal psychiatric symptoms in MS (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - October 9, 2023 Category: Neurology Authors: Heather Wood Source Type: research
PD pathology spread linked to mtDNA damage
Nature Reviews Neurology, Published online: 09 October 2023; doi:10.1038/s41582-023-00889-wPD pathology spread linked to mtDNA damage (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - October 9, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Seizure-associated changes in the Golgi apparatus
Nature Reviews Neurology, Published online: 09 October 2023; doi:10.1038/s41582-023-00886-zSeizure-associated changes in the Golgi apparatus (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - October 9, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Regrowth and recovery in mice with spinal cord injury
Nature Reviews Neurology, Published online: 09 October 2023; doi:10.1038/s41582-023-00890-3Directed axonal regeneration has restored walking function in mice with complete spinal cord injury. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - October 9, 2023 Category: Neurology Authors: Ian Fyfe Source Type: research
ApoE attracts microglia to amyloid-β plaques
Nature Reviews Neurology, Published online: 09 October 2023; doi:10.1038/s41582-023-00885-0A new study reveals that VCAM1–ApoE signalling directs microglia to amyloid-β plaques, mediating removal of the plaques by phagocytosis. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - October 9, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Linking the cerebellum to Parkinson disease: an update
Nature Reviews Neurology, Published online: 26 September 2023; doi:10.1038/s41582-023-00874-3Here, the authors discuss evidence for the involvement of the cerebellum in Parkinson disease. They cover the anatomical connections between the cerebellum and basal ganglia and how functional and connectivity alterations observed in the cerebellum of people with the disease relate to specific clinical symptoms. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 26, 2023 Category: Neurology Authors: Tianbai Li Weidong Le Joseph Jankovic Source Type: research
Rapid AQP4-IgG detection in neuromyelitis optica spectrum disorder
Nature Reviews Neurology, Published online: 22 September 2023; doi:10.1038/s41582-023-00882-3Researchers in China and South Korea have developed a rapid immunodot assay to detect aquaporin 4-targeting IgG autoantibodies in the serum of individuals with neuromyelitis optica spectrum disorder. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 22, 2023 Category: Neurology Authors: Heather Wood Source Type: research
The murky waters of sex differences in post-stroke cognitive impairment
Nature Reviews Neurology, Published online: 15 September 2023; doi:10.1038/s41582-023-00880-5A new study indicates that although men and women are equally likely to experience cognitive impairment after acute ischaemic stroke, there are sex differences in particular cognitive domains. Whether these differences are directly linked to biological sex is uncertain, as many factors, including age and pre-stroke factors, could contribute to cognitive outcomes. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 15, 2023 Category: Neurology Authors: Louise D. McCullough Source Type: research
The amyotrophic lateral sclerosis exposome: recent advances and future directions
Nature Reviews Neurology, Published online: 14 September 2023; doi:10.1038/s41582-023-00867-2The amyotrophic lateral sclerosis exposome is the lifetime accumulation of environmental exposures that increase disease risk and affect progression. This Review summarizes the literature that has sought to characterize aspects of the amyotrophic lateral sclerosis exposome and considers potential mechanisms of exposure-induced toxicity. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 14, 2023 Category: Neurology Authors: Stephen A. Goutman Masha G. Savelieff Dae-Gyu Jang Junguk Hur Eva L. Feldman Source Type: research
Clinical outcomes evolve years after traumatic brain injury
Nature Reviews Neurology, Published online: 12 September 2023; doi:10.1038/s41582-023-00868-1The TRACK-TBI LONG study has shown that outcomes are highly variable in the 7 years after traumatic brain injury (TBI). Although many patients remain stable, almost one-third experience declines in cognitive, psychiatric and functional state. These findings suggest that TBI is a chronic disease and that its management should change accordingly. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 12, 2023 Category: Neurology Authors: David J. Sharp Neil S. N. Graham Source Type: research
Lymphatic propagation of α-synuclein
Nature Reviews Neurology, Published online: 11 September 2023; doi:10.1038/s41582-023-00876-1Lymphatic propagation of α-synuclein (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 11, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Amyloid plaques: hotspots for microglial turnover
Nature Reviews Neurology, Published online: 11 September 2023; doi:10.1038/s41582-023-00875-2Amyloid plaques: hotspots for microglial turnover (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 11, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
