Origins and immunopathogenesis of autoimmune central nervous system disorders
This article reviews key pathogenic mechanisms underlying the development of CNS autoimmunity, focusing on the role of autoantibodies that target neuronal and/or glial cell-surface antigens. The authors consider novel therapeutic approaches based on knowledge of the immunopathogenesis of autoimmune CNS disorders. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 14, 2023 Category: Neurology Authors: Sudarshini Ramanathan Fabienne Brilot Sarosh R. Irani Russell C. Dale Source Type: research
Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications
Nature Reviews Neurology, Published online: 09 February 2023; doi:10.1038/s41582-023-00775-5In this Review, the authors provide an overview of the evidence indicating that multiple sclerosis is a rare complication of infection with the Epstein–Barr virus and discuss the mechanisms that could underlie this association. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 9, 2023 Category: Neurology Authors: Kjetil Bjornevik Christian M ünz Jeffrey I. Cohen Alberto Ascherio Source Type: research
Fetal neural precursor cell treatment for PD
Nature Reviews Neurology, Published online: 07 February 2023; doi:10.1038/s41582-023-00782-6Fetal neural precursor cell treatment for PD (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 7, 2023 Category: Neurology Authors: Sarah Lempri ère Source Type: research
Oestrogen receptor variants linked to AD traits
Nature Reviews Neurology, Published online: 07 February 2023; doi:10.1038/s41582-023-00784-4Oestrogen receptor variants linked to AD traits (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 7, 2023 Category: Neurology Authors: Sarah Lempri ère Source Type: research
White matter hyperintensities — location matters
Nature Reviews Neurology, Published online: 07 February 2023; doi:10.1038/s41582-023-00783-5White matter hyperintensities — location matters (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 7, 2023 Category: Neurology Authors: Sarah Lempri ère Source Type: research
Skin α-synuclein differentiates synucleinopathies
Nature Reviews Neurology, Published online: 07 February 2023; doi:10.1038/s41582-023-00785-3Skin α-synuclein differentiates synucleinopathies (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 7, 2023 Category: Neurology Authors: Sarah Lempri ère Source Type: research
Sex and gender in neurodevelopmental conditions
Nature Reviews Neurology, Published online: 06 February 2023; doi:10.1038/s41582-023-00774-6Here, Sven Bölte and colleagues consider the effects of sex and gender on neurodevelopmental conditions. They discuss the available epidemiological, behavioural, neurobiological and endocrinological evidence and highlight the importance of further research in this area. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 6, 2023 Category: Neurology Authors: Sven B ölte Janina Neufeld Peter B. Marschik Zachary J. Williams Louise Gallagher Meng-Chuan Lai Source Type: research
WNT receptor variant linked to synaptic degeneration
Nature Reviews Neurology, Published online: 02 February 2023; doi:10.1038/s41582-023-00781-7A genetic variant of the WNT receptor LRP6 exacerbates synapse degeneration in mouse models of ageing and Alzheimer’s disease, according to new research. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 2, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Lost empathy in FTD linked to prefrontal hypoexcitability
Nature Reviews Neurology, Published online: 02 February 2023; doi:10.1038/s41582-023-00780-8According to new research in a mouse model of frontotemporal dementia, hypoexcitability of the dorsomedial prefrontal cortex underlies lost empathy. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 2, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Epigenome editing of MECP2 rescues Rett syndrome neurons
Nature Reviews Neurology, Published online: 01 February 2023; doi:10.1038/s41582-023-00778-2In a new study, targeted editing of the epigenome was found to reactivate silenced MECP2 in human embryonic stem cells, suggesting that a similar approach could be used to treat Rett syndrome in girls. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 1, 2023 Category: Neurology Authors: Sarah Lempri ère Source Type: research
Global epidemiology of migraine and its implications for public health and health policy
Nature Reviews Neurology, Published online: 24 January 2023; doi:10.1038/s41582-022-00763-1Here, Timothy Steiner and Lars Stovner discuss the progression of migraine epidemiology over the last seven decades and question the apparent increase in migraine prevalence over time. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 24, 2023 Category: Neurology Authors: Timothy J. Steiner Lars Jacob Stovner Source Type: research
Cohort-guided insights into gene–environment interactions in autism spectrum disorders
Nature Reviews Neurology, Published online: 16 January 2023; doi:10.1038/s41582-022-00764-0In this Perspective article, Lipkin et al. consider the contribution of cohort studies to our understanding of autism spectrum disorders (ASDs) and debate the promise and potential challenges of such studies for dissecting the causes of ASDs and developing interventional strategies. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 16, 2023 Category: Neurology Authors: W. Ian Lipkin Michaeline Bresnahan Ezra Susser Source Type: research
Facioscapulohumeral muscular dystrophy: the road to targeted therapies
Nature Reviews Neurology, Published online: 10 January 2023; doi:10.1038/s41582-022-00762-2Facioscapulohumeral muscular dystrophy is caused by aberrant expression of the transcription factor DUX4. Tihaya, Mul and colleagues describe advances in the development of targeted treatments for facioscapulohumeral muscular dystrophy and discuss potential clinical trial outcome measures as well as molecular and imaging biomarkers. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 10, 2023 Category: Neurology Authors: Mara S. Tihaya Karlien Mul Judit Balog Jessica C. de Greef Stephen J. Tapscott Rabi Tawil Jeffrey M. Statland Silv ère M. van der Maarel Source Type: research
Biomarker-based diagnosis of preclinical Alzheimer disease: time for the clinic?
Nature Reviews Neurology, Published online: 10 January 2023; doi:10.1038/s41582-022-00767-xFindings from a worldwide cohort of cognitively unimpaired individuals demonstrate that the presence of two canonical Alzheimer disease biomarkers — amyloid and tau — can reliably predict progression to mild cognitive impairment in the short-term. The results support the use of these biomarkers to diagnose preclinical Alzheimer disease in a clinical setting. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 10, 2023 Category: Neurology Authors: Marwan N. Sabbagh Boris DeCourt Source Type: research
Calcium dysregulation could underlie lysosomal impairment in AD
Nature Reviews Neurology, Published online: 09 January 2023; doi:10.1038/s41582-022-00766-yNormalizing aberrant calcium release from the endoplasmic reticulum restores lysosome function in AD models. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 9, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
