Barriers to implementation of evidence into clinical practice in low-resource settings
Nature Reviews Neurology, Published online: 29 June 2022; doi:10.1038/s41582-022-00690-1Low-resource settings lag behind the rest of the world in achieving good health, in part owing to poor translation of clinical evidence into practice. Focusing on neurological disorders — in particular, stroke — this Comment identifies barriers to translation at the individual, provider and health systems levels and proposes theory-driven mitigating solutions. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 29, 2022 Category: Neurology Authors: Mayowa O. Owolabi Nijasri C. Suwanwela Joseph Yaria Source Type: research
Are guidelines a useful tool for improving outcomes in neurology?
Nature Reviews Neurology, Published online: 27 June 2022; doi:10.1038/s41582-022-00687-wA growing number of clinical practice guidelines are being developed for neurological diseases, and they have the potential to benefit patients, clinicians, policymakers and payers. However, the effectiveness of these guidelines has not been evaluated, so we do not yet know whether they improve patient outcomes in a real-world setting. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 27, 2022 Category: Neurology Authors: Maurizio A. Leone Joao Costa Source Type: research
Development and implementation of new diagnostic technologies in neurology
Nature Reviews Neurology, Published online: 27 June 2022; doi:10.1038/s41582-022-00692-zThe past 5–10 years have seen rapid advances in digital sensors and imaging-based technologies for the diagnosis of neurological conditions. However, the majority of these technologies are in the early stages of development — now is the time to consider how we validate these tools and safely integrate them into clinical practice. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 27, 2022 Category: Neurology Authors: Cristina Granziera Tim Woelfle Ludwig Kappos Source Type: research
The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic
Nature Reviews Neurology, Published online: 24 June 2022; doi:10.1038/s41582-022-00681-2The prominence of gastrointestinal dysfunction among the non-motor features of Parkinson disease (PD) indicates a close bidirectional link between the brain and the gut. This Review discusses the proposed roles of gut-related factors in PD development, progression and treatment responses, and as therapeutic targets. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 24, 2022 Category: Neurology Authors: Ai Huey Tan Shen Yang Lim Anthony E. Lang Source Type: research
Emerging therapies to target CNS pathophysiology in multiple sclerosis
Nature Reviews Neurology, Published online: 13 June 2022; doi:10.1038/s41582-022-00675-0In this Review, Oh and Bar-Or provide an overview of selected emerging therapies for multiple sclerosis with the potential to limit non-relapsing, progressive disease injury and to promote tissue repair, thereby addressing crucial unmet therapeutic needs. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 13, 2022 Category: Neurology Authors: Jiwon Oh Amit Bar-Or Source Type: research
Closing the loop for patients with Parkinson disease: where are we?
Nature Reviews Neurology, Published online: 09 June 2022; doi:10.1038/s41582-022-00674-1In this Perspective, the authors present their vision for a closed-loop system for automatic symptom monitoring and levodopa administration in individuals with Parkinson disease. The system would capitalize on the ongoing advances in wearable sensor technology, drug delivery systems and machine learning. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 9, 2022 Category: Neurology Authors: Hazhir Teymourian Farshad Tehrani Katherine Longardner Kuldeep Mahato Tatiana Podhajny Jong-Min Moon Yugender Goud Kotagiri Juliane R. Sempionatto Irene Litvan Joseph Wang Source Type: research
Cholesterol is important for tau propagation
Nature Reviews Neurology, Published online: 08 June 2022; doi:10.1038/s41582-022-00685-yCholesterol is important for tau propagation (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 8, 2022 Category: Neurology Authors: Ian Fyfe Source Type: research
Vulnerable dopamine neurons identified
Nature Reviews Neurology, Published online: 08 June 2022; doi:10.1038/s41582-022-00682-1Vulnerable dopamine neurons identified (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 8, 2022 Category: Neurology Authors: Ian Fyfe Source Type: research
Nusinersen treatment response markers
Nature Reviews Neurology, Published online: 08 June 2022; doi:10.1038/s41582-022-00684-zNusinersen treatment response markers (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 8, 2022 Category: Neurology Authors: Ian Fyfe Source Type: research
Gene therapy protects against neuroinflammation
Nature Reviews Neurology, Published online: 08 June 2022; doi:10.1038/s41582-022-00683-0Gene therapy protects against neuroinflammation (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - June 8, 2022 Category: Neurology Authors: Ian Fyfe Source Type: research
Ageing reduces potential for remyelination in multiple sclerosis
Nature Reviews Neurology, Published online: 31 May 2022; doi:10.1038/s41582-022-00680-3Drug-enhanced remyelination in people with multiple sclerosis is less efficient in older individuals, new analysis shows. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 31, 2022 Category: Neurology Authors: Ian Fyfe Source Type: research
Genome-wide analysis furthers decoding of Alzheimer disease genetics
Nature Reviews Neurology, Published online: 27 May 2022; doi:10.1038/s41582-022-00678-xA new genome-wide association study has identified 41 previously unknown loci associated with Alzheimer disease. However, these data provide limited insight into disease mechanisms or benefits for clinical prediction of Alzheimer disease. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 27, 2022 Category: Neurology Authors: Christina M. Lill Lars Bertram Source Type: research
Meningeal lymphatics mediate drainage of viruses from the CNS
Nature Reviews Neurology, Published online: 25 May 2022; doi:10.1038/s41582-022-00677-yNew research shows that meningeal lymphatic vessels can drain viruses from the CNS, with important implications for our understanding of CNS infections. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 25, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research
Anti-inflammatory drugs could cause chronic pain
Nature Reviews Neurology, Published online: 24 May 2022; doi:10.1038/s41582-022-00676-zA new study provides evidence that inflammation protects against the development of chronic pain in people with acute back pain, and that anti-inflammatory drugs used to treat acute pain could do more harm than good in the long term. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 24, 2022 Category: Neurology Authors: Heather Wood Source Type: research
CMS coverage decision on anti-amyloid monoclonal antibodies for Alzheimer disease
Nature Reviews Neurology, Published online: 20 May 2022; doi:10.1038/s41582-022-00672-3On the basis of a coverage decision for anti-amyloid monoclonal antibodies recently issued by the US Centers for Medicare and Medicaid Services, Medicare will offer ‘coverage with evidence development’ to allow more information on the clinical benefits of these antibodies to be gathered. Here, we discuss the implications of this decision for future clinical trials and Alzheimer disease care. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - May 20, 2022 Category: Neurology Authors: David Knopman Mary Sano Howard H. Feldman Source Type: research
