Glial response to Parkinson disease-like neurodegeneration is region-dependent
Nature Reviews Neurology, Published online: 29 November 2022; doi:10.1038/s41582-022-00754-2According to new findings in a mouse model of Parkinson disease, the glial response to nigrostriatal degeneration differs depending on brain region. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 29, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research
Targeting connexin hemichannels to treat temporal lobe epilepsy
Nature Reviews Neurology, Published online: 22 November 2022; doi:10.1038/s41582-022-00752-4Targeting connexin hemichannels to treat temporal lobe epilepsy (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 22, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
Maximizing treatment efficacy through patient stratification in neuropathic pain trials
Nature Reviews Neurology, Published online: 18 November 2022; doi:10.1038/s41582-022-00741-7Despite substantial research advances, treatment of neuropathic pain remains inadequate and responses to treatment are highly variable. In this Perspective, the authors argue that rational stratification of patients with neuropathic pain will aid identification of subgroups of patients who will benefit most from a given treatment. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 18, 2022 Category: Neurology Authors: Ralf Baron Anthony H. Dickenson Margarita Calvo Sulayman D. Dib-Hajj David L. Bennett Source Type: research
Looking for lights in the fog of long-term neurological COVID
Nature Reviews Neurology, Published online: 18 November 2022; doi:10.1038/s41582-022-00750-6A new study provides evidence for an association between COVID-19 and long-term neurological syndromes. The findings highlight the need for further research into the long-term neurological consequences of SARS-CoV-2 infection and the development of strategies that lessen the effects of these consequences on patient quality of life and on healthcare systems. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 18, 2022 Category: Neurology Authors: Alessandro Padovani Andrea Pilotto Source Type: research
Cell-based therapies for neurological disorders — the bioreactor hypothesis
Nature Reviews Neurology, Published online: 17 November 2022; doi:10.1038/s41582-022-00736-4In this Review, Savitz and Cox consider the evidence for a model of cell-based therapy referred to as the bioreactor hypothesis, in which exogenous cells migrate to peripheral organs and reprogramme host immune cells to generate an anti-inflammatory, regenerative environment. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 17, 2022 Category: Neurology Authors: Sean I. Savitz Charles S. Cox Jr Source Type: research
New IDEAS about amyloid, race and dementia disparities
Nature Reviews Neurology, Published online: 15 November 2022; doi:10.1038/s41582-022-00748-0In a study of 17,000 Medicare beneficiaries with mild cognitive impairment or dementia, non-Hispanic white older adults were more likely than Asian, Black or Hispanic older adults to have elevated cortical amyloid, as measured by PET. These findings have important implications for the use of amyloid-targeting therapies. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 15, 2022 Category: Neurology Authors: Heather E. Dark Keenan A. Walker Source Type: research
Adaptive and maladaptive myelination in health and disease
Nature Reviews Neurology, Published online: 14 November 2022; doi:10.1038/s41582-022-00737-3In this Review, the authors provide an overview of evidence that activity-regulated myelination is required for brain adaptation and learning, and discuss how dysregulation of activity-dependent myelination contributes to neurological disease and could be a new therapeutic target. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 14, 2022 Category: Neurology Authors: Juliet K. Knowles Ankita Batra Haojun Xu Michelle Monje Source Type: research
social determinants of health in multiple sclerosis
Nature Reviews Neurology, Published online: 11 November 2022; doi:10.1038/s41582-022-00735-5Here, the authors discuss the potential effects of social determinants of health on multiple sclerosis risk and outcomes. They suggest that addressing these determinants of health could substantially improve the lives of individuals with multiple sclerosis and call for more research. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 11, 2022 Category: Neurology Authors: Ruth Dobson Dylan R. Rice Marie D ’hooghe Rachel Horne Yvonne Learmonth Farrah J. Mateen Claudia H. Marck Sa úl Reyes Mitzi Joi Williams Gavin Giovannoni Helen L. Ford Source Type: research
Dementia risk variants — hunting needles in a haystack
Nature Reviews Neurology, Published online: 03 November 2022; doi:10.1038/s41582-022-00739-1Genome-wide association studies have identified loci associated with neurodegenerative disease risk, but many of the implicated genetic variants are noncoding and their functional roles remain unclear. Using massively parallel reporter assays, CRISPR-based validation and genomic annotations, a new study functionally characterizes regulatory risk variants associated with Alzheimer disease and progressive supranuclear palsy. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 3, 2022 Category: Neurology Authors: Stephanie R. Oatman Nil üfer Ertekin-Taner Source Type: research
Novel plasma markers for Parkinson disease
Nature Reviews Neurology, Published online: 02 November 2022; doi:10.1038/s41582-022-00746-2Novel plasma markers for Parkinson disease (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 2, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
Blood–brain barrier dysfunction following TBI
Nature Reviews Neurology, Published online: 02 November 2022; doi:10.1038/s41582-022-00747-1Blood–brain barrier dysfunction following TBI (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 2, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
NUMB72 — a therapeutic target for tauopathies?
Nature Reviews Neurology, Published online: 02 November 2022; doi:10.1038/s41582-022-00745-3NUMB72 — a therapeutic target for tauopathies? (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 2, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
Preventing COVID-19 neurological complications
Nature Reviews Neurology, Published online: 02 November 2022; doi:10.1038/s41582-022-00744-4Preventing COVID-19 neurological complications (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 2, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
No seasonality in multiple sclerosis risk near the Equator
Nature Reviews Neurology, Published online: 01 November 2022; doi:10.1038/s41582-022-00743-5New findings indicate that seasonal differences in multiple sclerosis prevalence are latitude-dependent. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 1, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
Impaired glymphatic drainage links amyloid and tau to cognitive dysfunction
Nature Reviews Neurology, Published online: 01 November 2022; doi:10.1038/s41582-022-00742-6New findings suggest that glymphatic dysfunction mediates the effect of amyloid and tau pathology on cognition. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 1, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research
