Endemic parkinsonism: clusters, biology and clinical features
Nature Reviews Neurology, Published online: 08 September 2023; doi:10.1038/s41582-023-00866-3Endemic parkinsonism occurs only in specific locations or populations. Here, Menšíková et al. describe clusters of endemic parkinsonism and highlight that those linked to neurotoxic environmental factors seem to be disappearing, while genetically determined clusters persist. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 8, 2023 Category: Neurology Authors: Katerina Men šíková John C. Steele Raymond Rosales Carlo Colosimo Peter Spencer Annie Lannuzel Yoshikazu Ugawa Ryogen Sasaki Santiago Gim énez-Roldán Radoslav Matej Lucie Tuckova Dominik Hrabos Kristyna Kolarikova Radek Vodicka Radek Vrtel Miroslav S Source Type: research
Evidence-based clinical care and policy making for schizophrenia
Nature Reviews Neurology, Published online: 07 September 2023; doi:10.1038/s41582-023-00872-5Two recent studies leverage the same French population-based disease registry to describe real-world medication prescription patterns, patient characteristics and treatment effectiveness in people with schizophrenia. These studies also identify disparities in the health care and outcomes of these individuals compared with those of the general population. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 7, 2023 Category: Neurology Authors: Marco Solmi Christoph U. Correll Source Type: research
27-Hydroxycholesterol propagates α-synuclein pathology in Parkinson disease
Nature Reviews Neurology, Published online: 05 September 2023; doi:10.1038/s41582-023-00873-4New research in a mouse model of Parkinson disease indicates that the cholesterol metabolite 27-hydroxycholesterol drives α-synuclein pathology. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 5, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Treatments for AD: towards the right target at the right time
Nature Reviews Neurology, Published online: 01 September 2023; doi:10.1038/s41582-023-00869-0Results from the phase III trials of the amyloid-targeting antibodies donanemab and solanezumab add further evidence that amyloid pathology is a key driver of cognitive decline in Alzheimer disease. The mixed results highlight important considerations for future trials and clinical practice. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 1, 2023 Category: Neurology Authors: Wiesje M. van der Flier Betty M. Tijms Source Type: research
Insights into influences on Alzheimer disease blood biomarkers
Nature Reviews Neurology, Published online: 01 September 2023; doi:10.1038/s41582-023-00871-6Blood biomarkers of Alzheimer disease are influenced by sex and medical comorbidities but not by race, according new research. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - September 1, 2023 Category: Neurology Authors: Ian Fyfe Source Type: research
The translational potential of cholesterol-based therapies for neurological disease
Nature Reviews Neurology, Published online: 29 August 2023; doi:10.1038/s41582-023-00864-5Cholesterol has diverse roles in the brain, and precise regulation of cholesterol production and catabolism is essential for healthy brain function. This Review summarizes cholesterol regulation and function in the brain and discusses evidence of cholesterol dyshomeostasis in age-related neuropathology and a number of neurological diseases. In particular, the authors focus on Huntington disease and insights from rodent models. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 29, 2023 Category: Neurology Authors: Marta Valenza Giulia Birolini Elena Cattaneo Source Type: research
New mechanistic insights into TDP-43 pathology
Nature Reviews Neurology, Published online: 22 August 2023; doi:10.1038/s41582-023-00870-7Two new studies have provided important mechanistic insights into TDP-43 pathology, a hallmark of neurodegenerative conditions such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 22, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Psychiatric sequelae of traumatic brain injury — future directions in research
Nature Reviews Neurology, Published online: 17 August 2023; doi:10.1038/s41582-023-00853-8Understanding of the psychiatric and behavioural consequences of traumatic brain injury (TBI) remains limited. In this Review, Li and colleagues highlight ways to progress research in this field and discuss neuropsychiatric sequelae of TBI that affect long-term health outcomes and functional recovery. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 17, 2023 Category: Neurology Authors: Lucia M. Li Alan Carson Kristen Dams-O ’Connor Source Type: research
Limbic-predominant age-related TDP43 encephalopathy (LATE) neuropathological change in neurodegenerative diseases
Nature Reviews Neurology, Published online: 10 August 2023; doi:10.1038/s41582-023-00846-7Limbic-predominant age-related TDP43 encephalopathy (LATE) is a clinical entity characterized by amnestic dementia resembling Alzheimer disease. This Review focuses on the pathology, genetic risk factors and clinical features associated with pure LATE neuropathological change and LATE neuropathological change with coexisting pathologies. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 10, 2023 Category: Neurology Authors: Sukriti Nag Julie A. Schneider Source Type: research
Inverse association between age and inflammatory disease activity in multiple sclerosis
Nature Reviews Neurology, Published online: 10 August 2023; doi:10.1038/s41582-023-00844-9Two studies have confirmed previous observations that an inverse relationship exists between chronological age and focal white-matter inflammatory activity in individuals with multiple sclerosis, which could underlie the relative ineffectiveness of traditional disease-modifying therapies in older individuals. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 10, 2023 Category: Neurology Authors: Benjamin M. Segal Source Type: research
Restoring myogenesis in myotonic dystrophy
Nature Reviews Neurology, Published online: 08 August 2023; doi:10.1038/s41582-023-00862-7Restoring myogenesis in myotonic dystrophy (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2023 Category: Neurology Authors: Heather Wood Source Type: research
X-chromosome variants and PD in Latin America
Nature Reviews Neurology, Published online: 08 August 2023; doi:10.1038/s41582-023-00861-8X-chromosome variants and PD in Latin America (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2023 Category: Neurology Authors: Heather Wood Source Type: research
LONRF2 exerts protein quality control in ageing neurons
Nature Reviews Neurology, Published online: 08 August 2023; doi:10.1038/s41582-023-00859-2A new study identifies LONRF2 as a protein quality control ubiquitin ligase that is induced in senescent neurons and seems to protect them against degeneration (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Effects of diet on MS onset and course
Nature Reviews Neurology, Published online: 08 August 2023; doi:10.1038/s41582-023-00863-6Effects of diet on MS onset and course (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Neurofilament marks prodrome onset in FTD
Nature Reviews Neurology, Published online: 08 August 2023; doi:10.1038/s41582-023-00860-9Neurofilament marks prodrome onset in FTD (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2023 Category: Neurology Authors: Heather Wood Source Type: research
