Blood–brain barrier disruption following seizures
Nature Reviews Neurology, Published online: 10 March 2023; doi:10.1038/s41582-023-00794-2New research reports changes in serum blood–brain barrier (BBB) markers after bilateral tonic–clonic seizures, corroborating earlier observations in animal models. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 10, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Psychotic disorders as a framework for precision psychiatry
Nature Reviews Neurology, Published online: 06 March 2023; doi:10.1038/s41582-023-00779-1In this Review, the authors discuss recent efforts to predict disease onset, treatment response and disease outcome in individuals with psychosis. They cover genetic, biological, clinical and environmental predictive factors and assess whether the variation in outcomes is attributable to differences in the pathophysiology of psychosis. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 6, 2023 Category: Neurology Authors: Fiona Coutts Nikolaos Koutsouleris Philip McGuire Source Type: research
Predictive tools in psychosis: what is ‘good enough’?
Nature Reviews Neurology, Published online: 06 March 2023; doi:10.1038/s41582-023-00787-1Prediction tools offer great promise for clinicians in the prevention and treatment of psychosis, but none has been routinely implemented. Greater methodological rigour in the development and evaluation of these tools, along with consideration of a range of performance criteria, is necessary to maximize their potential for improving clinical decision making. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 6, 2023 Category: Neurology Authors: Aida Seyedsalehi Belinda Lennox Source Type: research
Precision medicine for psychosis: a revolution at the interface of psychiatry and neurology
Nature Reviews Neurology, Published online: 06 March 2023; doi:10.1038/s41582-023-00788-0A growing understanding of the neurobiology of psychosis offers hope for an improvement in the standard of care; this includes the development of individualized, precision therapeutics. However, the path to precision psychiatry is long, and progress would be accelerated by greater collaboration with the fields of neurology and neuroscience. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 6, 2023 Category: Neurology Authors: Matcheri S. Keshavan Brett A. Clementz Source Type: research
MRI-based deep learning for TLE diagnosis
Nature Reviews Neurology, Published online: 03 March 2023; doi:10.1038/s41582-023-00798-yMRI-based deep learning for TLE diagnosis (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 3, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Long-term risk of seizure following PRES
Nature Reviews Neurology, Published online: 03 March 2023; doi:10.1038/s41582-023-00796-0Long-term risk of seizure following PRES (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 3, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Risk locus for paediatric astrocytoma identified
Nature Reviews Neurology, Published online: 03 March 2023; doi:10.1038/s41582-023-00795-1Risk locus for paediatric astrocytoma identified (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 3, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Ultrasound ablation treatment for PD
Nature Reviews Neurology, Published online: 03 March 2023; doi:10.1038/s41582-023-00797-zUltrasound ablation treatment for PD (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 3, 2023 Category: Neurology Authors: Lisa Kiani Source Type: research
Viral pathogens increase risk of neurodegenerative disease
Nature Reviews Neurology, Published online: 02 March 2023; doi:10.1038/s41582-023-00790-6A new study, drawing on data from national biobanks, adds to the growing evidence that exposure to common viral pathogens increases the risk of Alzheimer disease and other neurodegenerative diseases. These findings might provide insights into the initiating factors that lead to neurodegeneration. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 2, 2023 Category: Neurology Authors: Britanie M. Blackhurst Kristen E. Funk Source Type: research
Pain-resolving immune mechanisms in neuropathic pain
Nature Reviews Neurology, Published online: 01 March 2023; doi:10.1038/s41582-023-00777-3Chronic neuropathic pain is a leading cause of disability that remains therapeutically challenging. Here, Fiore et al. review the immune mechanisms that contribute to the resolution of chronic neuropathic pain. Contributions of the gut microbiome and specialized pro-resolving mediators are also discussed, along with potential therapeutic strategies. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 1, 2023 Category: Neurology Authors: Nathan T. Fiore Sophie R. Debs Jessica P. Hayes Samuel S. Duffy Gila Moalem-Taylor Source Type: research
Neuroinflammation in spinal muscular atrophy
Nature Reviews Neurology, Published online: 01 March 2023; doi:10.1038/s41582-023-00791-5A new study reports upregulation of pro-inflammatory cytokines and neurotrophic factors in the cerebrospinal fluid of individuals with a severe form of spinal muscular atrophy. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - March 1, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Extracellular protein homeostasis in neurodegenerative diseases
Nature Reviews Neurology, Published online: 24 February 2023; doi:10.1038/s41582-023-00786-2Wilson et al. review our current knowledge of the extracellular proteostasis system that protects the brain from the pathological consequences of extracellular protein aggregation. They discuss growing evidence that impairment of this system contributes to neuronal death in neurodegenerative diseases. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 24, 2023 Category: Neurology Authors: Mark R. Wilson Sandeep Satapathy Michele Vendruscolo Source Type: research
Why functional neurological disorder is not feigning or malingering
Nature Reviews Neurology, Published online: 16 February 2023; doi:10.1038/s41582-022-00765-zIn this Perspective, Edwards and colleagues present their opinion that functional neurological disorder is categorically different from feigning and malingering. They discuss clinical, epidemiological and experimental evidence in support of this view. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 16, 2023 Category: Neurology Authors: Mark J. Edwards Mahinda Yogarajah Jon Stone Source Type: research
Origins and immunopathogenesis of autoimmune central nervous system disorders
This article reviews key pathogenic mechanisms underlying the development of CNS autoimmunity, focusing on the role of autoantibodies that target neuronal and/or glial cell-surface antigens. The authors consider novel therapeutic approaches based on knowledge of the immunopathogenesis of autoimmune CNS disorders. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 14, 2023 Category: Neurology Authors: Sudarshini Ramanathan Fabienne Brilot Sarosh R. Irani Russell C. Dale Source Type: research
Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications
Nature Reviews Neurology, Published online: 09 February 2023; doi:10.1038/s41582-023-00775-5In this Review, the authors provide an overview of the evidence indicating that multiple sclerosis is a rare complication of infection with the Epstein–Barr virus and discuss the mechanisms that could underlie this association. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - February 9, 2023 Category: Neurology Authors: Kjetil Bjornevik Christian M ünz Jeffrey I. Cohen Alberto Ascherio Source Type: research
