A first step towards preventive medicine in multiple sclerosis
Nature Reviews Neurology, Published online: 05 January 2023; doi:10.1038/s41582-022-00769-9The results of the first randomized, placebo-controlled trial of dimethyl fumarate in a cohort of participants with radiologically isolated syndrome showed efficacy against the risk of a first clinical demyelinating event. The findings pave the way for preventive medicine in multiple sclerosis and highlight the need for more precise prognostication of risk. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 5, 2023 Category: Neurology Authors: Maria Pia Amato Emilio Portaccio Source Type: research
Spinal cord transcriptome provides ALS insights
Nature Reviews Neurology, Published online: 03 January 2023; doi:10.1038/s41582-022-00772-0Spinal cord transcriptome provides ALS insights (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 3, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Iron chelator therapy leads to PD worsening
Nature Reviews Neurology, Published online: 03 January 2023; doi:10.1038/s41582-022-00771-1Iron chelator therapy leads to PD worsening (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 3, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Dual function of biomolecular condensates
Nature Reviews Neurology, Published online: 03 January 2023; doi:10.1038/s41582-022-00773-zDual function of biomolecular condensates (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - January 3, 2023 Category: Neurology Authors: Heather Wood Source Type: research
Functional brain networks in the evaluation of patients with neurodegenerative disorders
Nature Reviews Neurology, Published online: 20 December 2022; doi:10.1038/s41582-022-00753-3Advances in neuroimaging research have enabled the development of predictive models that integrate information from multiple brain systems. Here, Perovnik, Rus and colleagues discuss the detection and validation of neurodegenerative disease-specific functional brain networks and consider their relationship to pathological processes and disease-related genotypes. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 20, 2022 Category: Neurology Authors: Matej Perovnik Toma ž Rus Katharina A. Schindlbeck David Eidelberg Source Type: research
From precision diagnosis to precision treatment in epilepsy
Nature Reviews Neurology, Published online: 15 December 2022; doi:10.1038/s41582-022-00756-0Technological advances over the past decade have made precision genetic diagnosis available to many patients. The findings of a new study demonstrate that genetic diagnosis in epilepsy can lead to changes in clinical management that manifest as positive outcomes for the patient. The results herald a new era in which precision diagnosis will lead to precision medicine. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 15, 2022 Category: Neurology Authors: Katrine M. Johannesen Source Type: research
Synaptic degeneration in Alzheimer disease
Nature Reviews Neurology, Published online: 13 December 2022; doi:10.1038/s41582-022-00749-zHere, Spires-Jones and colleagues review our current understanding of the mechanisms underlying synaptic degeneration in Alzheimer disease and highlight key questions that still need to be answered. They also discuss novel therapeutic approaches that target the synapse. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 13, 2022 Category: Neurology Authors: Makis Tzioras Robert I. McGeachan Claire S. Durrant Tara L. Spires-Jones Source Type: research
‘On-demand’ gene therapy for epilepsy
Nature Reviews Neurology, Published online: 12 December 2022; doi:10.1038/s41582-022-00761-3Gene therapies show promise for treating epilepsy, but most strategies target cells across an entire brain region rather than selecting pathologically hyperexcited neurons. Researchers have now developed a conditional gene therapy strategy that downregulates firing activity only in neurons that are pathologically overactive and switches off when brain circuit activity has returned to baseline. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 12, 2022 Category: Neurology Authors: Pasquale Striano Fabio Benfenati Source Type: research
Prospects for gene replacement therapies in amyotrophic lateral sclerosis
Nature Reviews Neurology, Published online: 08 December 2022; doi:10.1038/s41582-022-00751-5Amyotrophic lateral sclerosis (ALS) is a devastating, incurable disease characterized by progressive loss of upper and lower motor neurons. Here, the authors describe the current landscape of genetic therapies for ALS and discuss new opportunities for gene replacement therapy, focusing on loss-of-function mutations. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 8, 2022 Category: Neurology Authors: Ilaria Giovannelli Adrian Higginbottom Janine Kirby Mimoun Azzouz Pamela J. Shaw Source Type: research
Neuroimmune transcriptome in brain disorders
Nature Reviews Neurology, Published online: 07 December 2022; doi:10.1038/s41582-022-00758-yNeuroimmune transcriptome in brain disorders (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 7, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
Cholesterol pathway associated with MS disability
Nature Reviews Neurology, Published online: 07 December 2022; doi:10.1038/s41582-022-00757-zCholesterol pathway associated with MS disability (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 7, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
Serum NfL as an MS biomarker
Nature Reviews Neurology, Published online: 07 December 2022; doi:10.1038/s41582-022-00760-4Serum NfL as an MS biomarker (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 7, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
Exome sequencing identifies risk variants for AD
Nature Reviews Neurology, Published online: 07 December 2022; doi:10.1038/s41582-022-00759-xExome sequencing identifies risk variants for AD (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 7, 2022 Category: Neurology Authors: Lisa Kiani Source Type: research
Gut microbiome changes linked to Parkinson disease
Nature Reviews Neurology, Published online: 01 December 2022; doi:10.1038/s41582-022-00755-1A new study used a metagenomic approach to survey the entire gut microbiome in people with Parkinson disease and identified specific changes that could be linked to the pathogenesis of the disease. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - December 1, 2022 Category: Neurology Authors: Heather Wood Source Type: research
Glial response to Parkinson disease-like neurodegeneration is region-dependent
Nature Reviews Neurology, Published online: 29 November 2022; doi:10.1038/s41582-022-00754-2According to new findings in a mouse model of Parkinson disease, the glial response to nigrostriatal degeneration differs depending on brain region. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - November 29, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research
