Heading in the right direction
Nature Reviews Neurology, Published online: 23 August 2022; doi:10.1038/s41582-022-00712-yResponding to increasing concerns around adverse brain health outcomes among former football (soccer) players, the Football Association of England recently announced a trial ban on heading in matches for players aged under 12 years. This is a step in the right direction, but wider interventions to preserve brain health should not be forgotten. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 23, 2022 Category: Neurology Authors: William Stewart Alan Carson Source Type: research

Reactive astrocyte biomarkers mirror Alzheimer disease pathology
Nature Reviews Neurology, Published online: 23 August 2022; doi:10.1038/s41582-022-00713-xA new study indicates that cerebrospinal fluid levels of specific reactive astrocyte biomarkers reflect different Alzheimer disease pathologies in the brain. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 23, 2022 Category: Neurology Authors: Heather Wood Source Type: research

Pathogenic autoantibodies in multiple sclerosis — from a simple idea to a complex concept
Nature Reviews Neurology, Published online: 15 August 2022; doi:10.1038/s41582-022-00700-2Numerous studies have attempted to identify pathogenic autoantibodies in people with multiple sclerosis (MS), but their results are conflicting. In this Perspective, the authors explore the available evidence and provide their own opinions on a possible role for autoantibodies in MS. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 15, 2022 Category: Neurology Authors: Romana H öftberger Hans Lassmann Thomas Berger Markus Reindl Source Type: research

New local therapy strategies for brain tumours
Nature Reviews Neurology, Published online: 09 August 2022; doi:10.1038/s41582-022-00710-0Two research teams in China have developed new local therapy approaches that are designed to eliminate brain tumour cells while minimizing damage to the surrounding healthy tissue. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 9, 2022 Category: Neurology Authors: Heather Wood Source Type: research

Surprise neurovascular dysfunction in frontotemporal dementia
Nature Reviews Neurology, Published online: 09 August 2022; doi:10.1038/s41582-022-00705-xNeurovascular function is altered in one form of autosomal-dominant frontotemporal dementia (FTD), according to new research. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 9, 2022 Category: Neurology Authors: Ian Fyfe Source Type: research

The challenges of anti-tau therapeutics in Alzheimer disease
Nature Reviews Neurology, Published online: 08 August 2022; doi:10.1038/s41582-022-00702-0A phase II trial of the tau antibody semorinemab indicates that it has no clinical benefit in the earliest stages of Alzheimer disease. The repeated finding that antibody-mediated reductions in protein pathology have limited or no clinical benefit indicates that we need to consider more specific or combined therapeutic targets. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2022 Category: Neurology Authors: Francesco Panza Madia Lozupone Source Type: research

Phagocytes linked to cognitive dysfunction in neuro-HIV
Nature Reviews Neurology, Published online: 08 August 2022; doi:10.1038/s41582-022-00706-wPhagocytes linked to cognitive dysfunction in neuro-HIV (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Thalamic inflammation — a therapeutic target for brain injury?
Nature Reviews Neurology, Published online: 08 August 2022; doi:10.1038/s41582-022-00707-9Thalamic inflammation — a therapeutic target for brain injury? (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Hypothyroidism is associated with dementia risk
Nature Reviews Neurology, Published online: 08 August 2022; doi:10.1038/s41582-022-00708-8Hypothyroidism is associated with dementia risk (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Long-term safety of satralizumab in NMOSD
Nature Reviews Neurology, Published online: 08 August 2022; doi:10.1038/s41582-022-00709-7Long-term safety of satralizumab in NMOSD (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 8, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research

The role of the gut microbiota in multiple sclerosis
Nature Reviews Neurology, Published online: 05 August 2022; doi:10.1038/s41582-022-00697-8In this Review, the authors provide detailed insight into how the gut microbiota influences the immune system, with implications for neuroinflammation, and discuss the accumulating evidence that the gut microbiota is an important factor in multiple sclerosis pathogenesis and a potential therapeutic target. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 5, 2022 Category: Neurology Authors: Jorge Correale Reinhard Hohlfeld Sergio E. Baranzini Source Type: research

MRI predicts cognitive training effects in multiple sclerosis
Nature Reviews Neurology, Published online: 01 August 2022; doi:10.1038/s41582-022-00701-1Cognitive rehabilitation is a promising approach to limit the effect of cognitive impairment on patients with multiple sclerosis, although results so far are conflicting. A new study indicates that structural and functional MRI techniques could provide reliable measures to predict treatment responses and tailor the rehabilitative approach to each patient. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - August 1, 2022 Category: Neurology Authors: Massimo Filippi Paolo Preziosa Source Type: research

Epigenetic genes and epilepsy — emerging mechanisms and clinical applications
Nature Reviews Neurology, Published online: 20 July 2022; doi:10.1038/s41582-022-00693-yThis Review considers how variants in genes encoding proteins that regulate epigenetic mechanisms might contribute to epilepsy. The discussion is structured around five categories of epigenetic mechanisms: DNA methylation, histone modifications, histone–DNA crosstalk, non-coding RNAs and chromatin remodelling. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 20, 2022 Category: Neurology Authors: Karen M. J. Van Loo Gemma L. Carvill Albert J. Becker Karen Conboy Alica M. Goldman Katja Kobow Iscia Lopes-Cendes Christopher A. Reid Erwin A. van Vliet David C. Henshall Source Type: research

Brain–machine interface treats pain in rats
Nature Reviews Neurology, Published online: 18 July 2022; doi:10.1038/s41582-022-00699-6A new study describes a brain–machine interface that can detect pain episodes and deliver timely treatment in rats. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 18, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research

From the prodromal stage of multiple sclerosis to disease prevention
Nature Reviews Neurology, Published online: 15 July 2022; doi:10.1038/s41582-022-00686-xIn this Roadmap, Marrie and colleagues set out the steps needed to improve our understanding of the multiple sclerosis (MS) prodrome and develop standardized criteria for identifying individuals with prodromal MS, thereby facilitating trials of interventions that could slow progression to classical MS. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - July 15, 2022 Category: Neurology Authors: Ruth Ann Marrie Mark Allegretta Lisa F. Barcellos Bruce Bebo Peter A. Calabresi Jorge Correale Benjamin Davis Philip L. De Jager Christiane Gasperi Carla Greenbaum Anne Helme Bernhard Hemmer Pamela Kanellis Walter Kostich Douglas Landsman Christine Lebrun Source Type: research