Metabolism and exercise: the skeletal muscle clock takes centre stage
Nature Reviews Endocrinology, Published online: 01 February 2023; doi:10.1038/s41574-023-00805-8The skeletal muscle clock directs a circadian programme of gene expression that is fundamental to both skeletal muscle and systemic energy metabolism. Notably, exercise timing can influence the skeletal muscle clock, which provides a rationale for exploring its potential role as a chronotherapeutic strategy. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 1, 2023 Category: Endocrinology Authors: Ryan A. Martin Mark R. Viggars Karyn A. Esser Source Type: research
A pipeline for identification and validation of brain targets for weight loss
Nature Reviews Endocrinology, Published online: 25 January 2023; doi:10.1038/s41574-023-00803-wThe dorsal raphe nucleus (DRN) is emerging as a key regulator of food intake and energy expenditure but the molecular and functional heterogeneity of DRN neurons is largely unknown. A new study characterizes the role of glutamatergic DRN neurons in the control of food intake and identifies a pharmacological approach to target these neurons in obesity. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 25, 2023 Category: Endocrinology Authors: Anthony Tsang Clemence Blouet Source Type: research
Obesity induces epigenetic memory in innate immune cells
Nature Reviews Endocrinology, Published online: 23 January 2023; doi:10.1038/s41574-023-00806-7Obesity induces epigenetic memory in innate immune cells (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 23, 2023 Category: Endocrinology Authors: Olivia Tysoe Source Type: research
Towards a better understanding of diabetes mellitus using organoid models
Nature Reviews Endocrinology, Published online: 20 January 2023; doi:10.1038/s41574-022-00797-xOrganoid systems have great potential to improve the study of diseases such as diabetes mellitus. This Review assesses the progress in developing pancreatic organoids and bioengineered systems for modelling diabetes mellitus and its complications. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 20, 2023 Category: Endocrinology Authors: Belin Selcen Beydag-Tas öz Siham Yennek Anne Grapin-Botton Source Type: research
Variation in serotonin 2C receptor linked with obesity and behaviour
Nature Reviews Endocrinology, Published online: 19 January 2023; doi:10.1038/s41574-023-00804-9Variation in serotonin 2C receptor linked with obesity and behaviour (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 19, 2023 Category: Endocrinology Authors: Shimona Starling Source Type: research
The gut microbiota in obesity and weight management: microbes as friends or foe?
Nature Reviews Endocrinology, Published online: 17 January 2023; doi:10.1038/s41574-022-00794-0This Review outlines evidence that the gut microbiota is involved in regulating body weight homeostasis. In addition, the opportunities, limitations and challenges of using gut microbiota-related approaches as a means to achieve and maintain a healthy body weight in people with overweight or obesity are discussed. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 17, 2023 Category: Endocrinology Authors: Matthias Van Hul Patrice D. Cani Source Type: research
Applying the WHO global targets for diabetes mellitus
Nature Reviews Endocrinology, Published online: 16 January 2023; doi:10.1038/s41574-022-00793-1In May 2022, the WHO released global targets for diabetes mellitus. In this Viewpoint, experts from around the world discuss the challenges and opportunities in applying these targets. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 16, 2023 Category: Endocrinology Authors: Alice Y. Y. Cheng Mar ília Brito Gomes Sanjay Kalra Andre-Pascal Kengne Chantal Mathieu Jonathan E. Shaw Source Type: research
A fresh look at kisspeptin neuron synchronization
Nature Reviews Endocrinology, Published online: 16 January 2023; doi:10.1038/s41574-023-00802-xA fresh look at kisspeptin neuron synchronization (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 16, 2023 Category: Endocrinology Authors: Claire Greenhill Source Type: research
Knowledge in youth is wisdom in age: involving young people in research
Nature Reviews Endocrinology, Published online: 10 January 2023; doi:10.1038/s41574-022-00796-y“Adults have really boring ideas” is what we repeatedly learn from our participatory research with young people. Nevertheless, it is common practice that adults design research, questionnaires and interventions for young people. Not surprisingly, many research initiatives, questionnaires and interventions are utterly boring and a bad fit for the intended population. Consequently, many research efforts go to waste. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 10, 2023 Category: Endocrinology Authors: Mai J. M. Chinapaw Teatske M. Altenburg Source Type: research
New variant for monogenic obesity
Nature Reviews Endocrinology, Published online: 09 January 2023; doi:10.1038/s41574-022-00798-wNew variant for monogenic obesity (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 9, 2023 Category: Endocrinology Authors: Claire Greenhill Source Type: research
Precision medicine approach improves HbA1c outcomes in T2DM
Nature Reviews Endocrinology, Published online: 06 January 2023; doi:10.1038/s41574-022-00799-9Precision medicine approach improves HbA1c outcomes in T2DM (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 6, 2023 Category: Endocrinology Authors: Olivia Tysoe Source Type: research
Food odour recognition adjusts systemic metabolism to nutrient availability
Nature Reviews Endocrinology, Published online: 04 January 2023; doi:10.1038/s41574-022-00801-4Food odour recognition is involved in the food anticipatory response. A study in Nature Metabolism describes how the olfactory system differentially regulates metabolic adaptations depending on energy availability. These effects are mediated by a brain circuit involving the melanocortin system that controls systemic lipid utilization via the sympathetic nervous system. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 4, 2023 Category: Endocrinology Authors: Vincent Prevot Ruben Nogueiras Source Type: research
Monogenic diabetes mellitus hidden in autoantibody-negative diabetes mellitus
Nature Reviews Endocrinology, Published online: 04 January 2023; doi:10.1038/s41574-022-00800-5A considerable proportion of autoantibody-negative children with type 1 diabetes mellitus actually have monogenic forms of diabetes mellitus, which enables tailored treatment. Thus, a diagnosis of monogenic diabetes mellitus should be considered and genetically tested for in this group of patients, even if the clinical criteria for monogenic diabetes mellitus are not met. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 4, 2023 Category: Endocrinology Authors: Stepanka Pruhova Petra Dusatkova Source Type: research
Intermuscular adipose tissue in metabolic disease
Nature Reviews Endocrinology, Published online: 23 December 2022; doi:10.1038/s41574-022-00784-2Understanding of intermuscular adipose tissue has expanded over the past few years. This Review discusses the specific role of intermuscular adipose tissue in metabolic diseases in humans and in animal models, with a particular emphasis on the quantity and biological properties of this unique adipose tissue. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 23, 2022 Category: Endocrinology Authors: Bret H. Goodpaster Bryan C. Bergman Andrea M. Brennan Lauren M. Sparks Source Type: research
Uncovering how the GnRH pulse generator is controlled in female mice
Nature Reviews Endocrinology, Published online: 22 December 2022; doi:10.1038/s41574-022-00795-zUncovering how the GnRH pulse generator is controlled in female mice (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 22, 2022 Category: Endocrinology Authors: Claire Greenhill Source Type: research
