Targeting the central melanocortin system for the treatment of metabolic disorders
This article discusses the neuroanatomy and function of the central melanocortin circuitry, focusing on metabolic disorders. Progress and limitations of therapeutics targeting this system and potential strategies to improve melanocortin-based therapeutics are outlined. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - June 26, 2023 Category: Endocrinology Authors: Patrick Sweeney Luis E. Gimenez Ciria C. Hernandez Roger D. Cone Source Type: research
Current and future pharmacotherapies for obesity in children and adolescents
Nature Reviews Endocrinology, Published online: 19 June 2023; doi:10.1038/s41574-023-00858-9This Review highlights results from adolescent anti-obesity medication clinical trials published since 2020. In addition, the importance of a comprehensive and chronic care model for youth with obesity is discussed and the emerging pipeline of future anti-obesity medications is outlined. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - June 19, 2023 Category: Endocrinology Authors: Aaron S. Kelly Source Type: research
Heterogeneity and endotypes in type 1 diabetes mellitus
Nature Reviews Endocrinology, Published online: 19 June 2023; doi:10.1038/s41574-023-00853-0There is a growing awareness that type 1 diabetes mellitus (T1DM) is a heterogeneous disease that can be characterized into distinct endotypes. This Review discusses the evidence for endotypes in T1DM and explores the implications for clinical practice. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - June 19, 2023 Category: Endocrinology Authors: Maria J. Redondo Noel G. Morgan Source Type: research
Shining a light on age-related adrenal cancer progression
Nature Reviews Endocrinology, Published online: 16 June 2023; doi:10.1038/s41574-023-00864-xShining a light on age-related adrenal cancer progression (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - June 16, 2023 Category: Endocrinology Authors: Shimona Starling Source Type: research
Could leptin substitution therapy potentially terminate entrapment in anorexia nervosa?
Nature Reviews Endocrinology, Published online: 14 June 2023; doi:10.1038/s41574-023-00863-yCase studies of patients with anorexia nervosa revealed psychological improvements upon treatment with recombinant human leptin, including an alleviation of the entrapment in this eating disorder. Hypoleptinaemia induced by loss of adipose tissue mass might trigger psychological changes observed in starvation. Accordingly, leptin analogues might prove beneficial for treatment of anorexia nervosa. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - June 14, 2023 Category: Endocrinology Authors: Johannes Hebebrand Anke Hinney Jochen Antel Source Type: research
Tracing the biological roots of obesity resistance in humans
Nature Reviews Endocrinology, Published online: 08 June 2023; doi:10.1038/s41574-023-00862-zTracing the biological roots of obesity resistance in humans (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - June 8, 2023 Category: Endocrinology Authors: Jens Lund Source Type: research
Investigating the effects of artificial sweeteners
Nature Reviews Endocrinology, Published online: 07 June 2023; doi:10.1038/s41574-023-00860-1Investigating the effects of artificial sweeteners (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - June 7, 2023 Category: Endocrinology Authors: Silvia Radenkovic Source Type: research
Differences in stem cell-derived islets
Nature Reviews Endocrinology, Published online: 07 June 2023; doi:10.1038/s41574-023-00861-0Differences in stem cell-derived islets (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - June 7, 2023 Category: Endocrinology Authors: Claire Greenhill Source Type: research
Liver–bone crosstalk implicated in osteoporosis progression
Nature Reviews Endocrinology, Published online: 31 May 2023; doi:10.1038/s41574-023-00859-8Liver–bone crosstalk implicated in osteoporosis progression (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 31, 2023 Category: Endocrinology Authors: Olivia Tysoe Source Type: research
Therapeutic inertia in type 2 diabetes mellitus: a fine line between advancing and de-intensifying
Nature Reviews Endocrinology, Published online: 31 May 2023; doi:10.1038/s41574-023-00857-wType 2 diabetes mellitus is a progressive disease requiring regular monitoring and therapeutic changes. It is important that healthcare professionals embrace both ends of the spectrum of therapeutic inertia, including appropriate advancement and de-intensification of therapies. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 31, 2023 Category: Endocrinology Authors: Kamlesh Khunti Alice Y. Y. Cheng Source Type: research
A mitochondrial origin for inherited diabetes mellitus
Nature Reviews Endocrinology, Published online: 26 May 2023; doi:10.1038/s41574-023-00856-xA mitochondrial origin for inherited diabetes mellitus (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 26, 2023 Category: Endocrinology Authors: Brandon J. Berry Source Type: research
Artificial intelligence in diabetes mellitus and endocrine diseases — what can we expect?
Nature Reviews Endocrinology, Published online: 24 May 2023; doi:10.1038/s41574-023-00852-1Artificial intelligence has already revolutionized various fields in medicine and research. Due to the complex and interconnected nature of the endocrine system, it is an ideal area to further exploit and maximize the potential benefits of artificial intelligence. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 24, 2023 Category: Endocrinology Authors: Ioannis T. Oikonomakos Charlotte Steenblock Stefan R. Bornstein Source Type: research
Lipid droplet biogenesis and functions in health and disease
Nature Reviews Endocrinology, Published online: 23 May 2023; doi:10.1038/s41574-023-00845-0This Review outlines our current understanding of the biogenesis and functions of lipid droplets in health and disease, highlighting a key role for lipid droplet biogenesis in alleviating cellular stress. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 23, 2023 Category: Endocrinology Authors: Armella Zadoorian Ximing Du Hongyuan Yang Source Type: research
Gut microbiota influences effectiveness of anti-diabetic drug
Nature Reviews Endocrinology, Published online: 23 May 2023; doi:10.1038/s41574-023-00854-zGut microbiota influences effectiveness of anti-diabetic drug (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 23, 2023 Category: Endocrinology Authors: Claire Greenhill Source Type: research
How can social jetlag affect health?
Nature Reviews Endocrinology, Published online: 23 May 2023; doi:10.1038/s41574-023-00851-2Our lives are governed by three clocks: the social clock that organizes our lives with others (local time), the biological clock that controls our physiology (circadian time) and the sun clock that defines natural light and darkness. The more misaligned these clocks are, the higher our odds of developing certain diseases. ‘Social jetlag’ quantifies the difference between local and circadian time. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 23, 2023 Category: Endocrinology Authors: Till Roenneberg Source Type: research
