Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?
Nature Reviews Endocrinology, Published online: 18 April 2023; doi:10.1038/s41574-023-00826-3In type 1 diabetes, the immune system destroys pancreatic β-cells but not neighbouring α-cells. Here, the authors describe the key differences between β-cells and α-cells that could account for their differential autoimmune vulnerability, and how these differences could result in the preferential endurance and survival of α-cells over β-cells. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 18, 2023 Category: Endocrinology Authors: Decio L. Eizirik Florian Szymczak Roberto Mallone Source Type: research
Succinate signalling regulates leptin production in adipocytes
Nature Reviews Endocrinology, Published online: 17 April 2023; doi:10.1038/s41574-023-00838-zSuccinate signalling regulates leptin production in adipocytes (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 17, 2023 Category: Endocrinology Authors: Olivia Tysoe Source Type: research
Programming of metabolism by adipokines during development
Nature Reviews Endocrinology, Published online: 13 April 2023; doi:10.1038/s41574-023-00828-1Mammals are highly susceptible to being permanently influenced by maternal factors and nutritional status during the intrauterine and early postnatal periods. This Review summarizes and discusses the potential role of several adipokines, including leptin and adiponectin, in inducing metabolic programming through their effects during development. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 13, 2023 Category: Endocrinology Authors: Jose Donato Jr Source Type: research
The role of ChREBP in carbohydrate sensing and NAFLD development
Nature Reviews Endocrinology, Published online: 13 April 2023; doi:10.1038/s41574-023-00809-4The carbohydrate-responsive element binding protein (ChREBP) senses intracellular carbohydrates and activates many target genes, including those crucial for de novo lipogenesis in hepatocytes. This Review discusses mechanisms that regulate ChREBP activity, the role of ChREBP in nonalcoholic liver disease (NAFLD) and emerging NAFLD drug targets. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 13, 2023 Category: Endocrinology Authors: Marion R égnier Tha ïs Carbinatti Lucia Parlati Fadila Benhamed Catherine Postic Source Type: research
Variation in metformin pharmacokinetics
Nature Reviews Endocrinology, Published online: 03 April 2023; doi:10.1038/s41574-023-00834-3Variation in metformin pharmacokinetics (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 3, 2023 Category: Endocrinology Authors: Claire Greenhill Source Type: research
Author Correction: A perspective on treating type 1 diabetes mellitus before insulin is needed
Nature Reviews Endocrinology, Published online: 03 April 2023; doi:10.1038/s41574-023-00837-0Author Correction: A perspective on treating type 1 diabetes mellitus before insulin is needed (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 3, 2023 Category: Endocrinology Authors: Danijela Tatovic Parth Narendran Colin M. Dayan Source Type: research
Urban built environments: interventions for reducing cardiometabolic risks
Nature Reviews Endocrinology, Published online: 30 March 2023; doi:10.1038/s41574-023-00827-2Cities with varied development types and green space are known to be protective for cardiometabolic health, while those with higher traffic-related pollution, access to calorie-dense food and poorer perception of safety are detrimental. These factors should be considered when planning urban developments in lower-income and middle-income countries to reduce cardiometabolic disease burden. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 30, 2023 Category: Endocrinology Authors: Chinmoy Sarkar Ka Yan Lai Source Type: research
A new Article Series for adipose tissue
Nature Reviews Endocrinology, Published online: 30 March 2023; doi:10.1038/s41574-023-00832-5Adipose tissue is a complex organ that has crucial endocrine and metabolic functions in mammalian physiology. A new Article Series aims to collate adipose tissue content from Nature Reviews Endocrinology and provide a useful resource for researchers working in this field. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 30, 2023 Category: Endocrinology Source Type: research
Adipose tissue boosts muscle regeneration by supplying mesenchymal stromal cells
Nature Reviews Endocrinology, Published online: 29 March 2023; doi:10.1038/s41574-023-00831-6Tissue-resident stem cells have a central role in tissue regeneration, but other accessory cells are also required for efficient regeneration. A new study by Sastourné-Arrey and colleagues reveals a delicate mechanism of skeletal muscle regeneration through an unexpected type of inter-organ communication, in which stromal cells derived from adipose tissue support muscle regeneration. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 29, 2023 Category: Endocrinology Authors: Akiyoshi Uezumi Source Type: research
Engineering stem cells to recapitulate thyroid cancer
Nature Reviews Endocrinology, Published online: 28 March 2023; doi:10.1038/s41574-023-00830-7Engineering stem cells to recapitulate thyroid cancer (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 28, 2023 Category: Endocrinology Authors: Shimona Starling Source Type: research
CITED1 mediates sex-specific regulation of food intake in hypothalamic neurons
Nature Reviews Endocrinology, Published online: 22 March 2023; doi:10.1038/s41574-023-00829-0CITED1 mediates sex-specific regulation of food intake in hypothalamic neurons (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 22, 2023 Category: Endocrinology Authors: Olivia Tysoe Source Type: research
Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus
Nature Reviews Endocrinology, Published online: 20 March 2023; doi:10.1038/s41574-023-00818-3Small rodents are still the most widely used animal model to study the pathophysiology of diabetes mellitus but non-rodent species can also provide valuable insights. The advantages and disadvantages of selected animal models of diabetes mellitus are outlined in this Review. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 20, 2023 Category: Endocrinology Authors: Thomas A. Lutz Source Type: research
Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases
Nature Reviews Endocrinology, Published online: 17 March 2023; doi:10.1038/s41574-023-00817-4This Review highlights mechanisms of glucagon secretion from pancreatic α-cells, including paracrine actions in islets and α-cell–β-cell crosstalk. Dysregulated glucagon secretion in metabolic diseases is also considered and the clinical potential of targeting glucagon is discussed. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 17, 2023 Category: Endocrinology Authors: Sofie H ædersdal Andreas Andersen Filip K. Knop Tina Vilsb øll Source Type: research
A perspective on treating type 1 diabetes mellitus before insulin is needed
Nature Reviews Endocrinology, Published online: 13 March 2023; doi:10.1038/s41574-023-00816-5This Perspective discusses potential approaches to managing patients in the early stages of developing type 1 diabetes mellitus, which could enable the initiation of insulin therapy to be delayed in some patients. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 13, 2023 Category: Endocrinology Authors: Danijela Tatovic Parth Narendran Colin M. Dayan Source Type: research
Interventions in people newly diagnosed with type 1 diabetes mellitus
Nature Reviews Endocrinology, Published online: 10 March 2023; doi:10.1038/s41574-023-00825-4Interventions in people newly diagnosed with type 1 diabetes mellitus (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 10, 2023 Category: Endocrinology Authors: Claire Greenhill Source Type: research
