Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1
Nature Reviews Endocrinology, Published online: 12 December 2022; doi:10.1038/s41574-022-00783-3This Review highlights the extrapancreatic actions of the incretin hormones gastric inhibitory polypeptide and glucagon-like peptide 1. These peptides are active on tissues with cardiometabolic relevance, such as liver, adipose tissue, muscle, the immune, kidney, heart, blood vessels and the central nervous system. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 12, 2022 Category: Endocrinology Authors: Rola Hammoud Daniel J. Drucker Source Type: research

Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?
Nature Reviews Endocrinology, Published online: 09 December 2022; doi:10.1038/s41574-022-00780-6There is growing awareness of differences in susceptibility to SARS-CoV-2 infection and COVID-19 severity between men and women. This Review assesses the evidence for this disparity and its potential causes, with a focus on the role of sex hormones. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 9, 2022 Category: Endocrinology Authors: Nicola Lott Caroline E. Gebhard Susan Bengs Ahmed Haider Gabriela M. Kuster Vera Regitz-Zagrosek Catherine Gebhard Source Type: research

Highlights from SfE BES 2022
Nature Reviews Endocrinology, Published online: 05 December 2022; doi:10.1038/s41574-022-00787-zHighlights from SfE BES 2022 (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 5, 2022 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Gene-edited organoids enable sensitive assessment of peptide hormone variation
Nature Reviews Endocrinology, Published online: 01 December 2022; doi:10.1038/s41574-022-00786-0Gene-edited organoids enable sensitive assessment of peptide hormone variation (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 1, 2022 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

Approaches to addressing the rise in obesity levels
Nature Reviews Endocrinology, Published online: 30 November 2022; doi:10.1038/s41574-022-00777-1In this Viewpoint, experts in the fields of medical therapy, adipocyte biology, exercise and muscle, bariatric surgery, genetics, and public health give their perspectives on current and future progress in addressing the rising prevalence of obesity. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 30, 2022 Category: Endocrinology Authors: Caroline M. Apovian Xi-Rong Guo John A. Hawley Shahzeer Karmali Ruth J. F. Loos Wilma E. Waterlander Source Type: research

Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice
Nature Reviews Endocrinology, Published online: 29 November 2022; doi:10.1038/s41574-022-00776-2Cardiorenal diseases are common in patients with type 2 diabetes mellitus (T2DM), with substantial morbidity and premature mortality. This Review discusses how atherosclerotic cardiovascular disease and cardiorenal diseases can be prevented in T2DM, considering evidence from clinical trials and its implementation in clinical practice. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 29, 2022 Category: Endocrinology Authors: Lee-Ling Lim Elaine Chow Juliana C. N. Chan Source Type: research

Metabolic determinants of tumour initiation
Nature Reviews Endocrinology, Published online: 29 November 2022; doi:10.1038/s41574-022-00773-5This Review presents evidence that points to a critical role for metabolic pathways in influencing processes that support the early stages of tumour development, provides examples of the role of metabolic networks intrinsic to cancer cells in tumour progression and outlines how environmental factors can affect tumour incidence. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 29, 2022 Category: Endocrinology Authors: Julia S. Brunner Lydia W. S. Finley Source Type: research

Genomics suggest role for IGF1 resistance in T2DM
Nature Reviews Endocrinology, Published online: 21 November 2022; doi:10.1038/s41574-022-00782-4Genomics suggest role for IGF1 resistance in T2DM (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 21, 2022 Category: Endocrinology Authors: Shimona Starling Source Type: research

Macrophage mitochondrial levels of iron affect adipose tissue function in obesity
Nature Reviews Endocrinology, Published online: 17 November 2022; doi:10.1038/s41574-022-00781-5Macrophage mitochondrial levels of iron affect adipose tissue function in obesity (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 17, 2022 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

Promising findings in PTH replacement therapy trial
Nature Reviews Endocrinology, Published online: 08 November 2022; doi:10.1038/s41574-022-00779-zPromising findings in PTH replacement therapy trial (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 8, 2022 Category: Endocrinology Authors: Shimona Starling Source Type: research

Do psychedelics have therapeutic potential for obesity?
Nature Reviews Endocrinology, Published online: 03 November 2022; doi:10.1038/s41574-022-00769-1Classic psychedelics are being revisited as novel drug candidates. Researchers are investigating the efficacy of psychedelics for disorders such as depression and addiction. Facets of obesity pathophysiology are neurobiologically similar to these conditions, and we propose that obesity could be the next frontier in psychedelic research. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 3, 2022 Category: Endocrinology Authors: Nicole Fadahunsi Gitte Moos Knudsen Christoffer Clemmensen Source Type: research

SARS-CoV-2 fires up inflammation in adipose tissue
Nature Reviews Endocrinology, Published online: 02 November 2022; doi:10.1038/s41574-022-00778-0Obesity is an important risk factor for severe COVID-19 and, possibly, for breakthrough SARS-CoV-2 infections in fully vaccinated people. Novel findings highlight how SARS-CoV-2 infects adipose tissue and promotes subclinical inflammation. Thus, also based on knowledge about endocrine dysfunction facilitating SARS-CoV-2 infection, a vicious cycle involving obesity, impaired metabolic health and COVID-19 might exist. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 2, 2022 Category: Endocrinology Authors: Norbert Stefan Source Type: research

Functional HNF1A variants linked with T2DM risk in European-ancestry populations
Nature Reviews Endocrinology, Published online: 02 November 2022; doi:10.1038/s41574-022-00775-3Functional HNF1A variants linked with T2DM risk in European-ancestry populations (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 2, 2022 Category: Endocrinology Authors: Katrin Legg Source Type: research

REG3G — a potential link between the intestinal microbiome and host physiology
Nature Reviews Endocrinology, Published online: 01 November 2022; doi:10.1038/s41574-022-00774-4REG3G — a potential link between the intestinal microbiome and host physiology (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 1, 2022 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Hypoglycaemia in type 1 diabetes mellitus: risks and practical prevention strategies
Nature Reviews Endocrinology, Published online: 31 October 2022; doi:10.1038/s41574-022-00762-8Hypoglycaemia is a common occurrence in people with type 1 diabetes mellitus, and can have serious consequences. This Review defines hypoglycaemia in type 1 diabetes mellitus, and also outlines its frequency, risk factors and adverse outcomes. Ways to prevent and treat this complication of insulin therapy are also discussed. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - October 31, 2022 Category: Endocrinology Authors: Jasleen Kaur Elizabeth R. Seaquist Source Type: research