The Adc regulon mediates zinc homeostasis in Streptococcus mutans
This article is protected by copyright. All rights reserved (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - August 5, 2021 Category: Microbiology Authors: Yangyang Pan,
Yang Chen,
Jiamin Chen,
Qizhao Ma,
Tao Gong,
Shuxing Yu,
Qiong Zhang,
Jing Zou,
Yuqing Li Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - August 5, 2021 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research
Post ‐translational modification of Streptococcus sanguinis SpxB influences protein solubility and H2O2 production
This article is protected by copyright. All rights reserved (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 28, 2021 Category: Microbiology Authors: Rong Mu,
David Anderson,
Justin Merritt,
Hui Wu,
Jens Kreth Tags: ORIGINAL ARTICLE Source Type: research
Prediction of early childhood caries onset and oral microbiota
(Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 27, 2021 Category: Microbiology Authors: Robert G. Quivey,
Thomas G. O'Connor,
Steven R. Gill,
Dorota T. Kopycka ‐Kedzierawski Tags: INVITED REVIEW Source Type: research
Identification and characterization of a UbK family kinase in Porphyromonas gingivalis that phosphorylates the RprY response regulator
We report here the identification of a Ubiquitous bacterial Kinase (UbK) family member, designated UbK1, in the anaerobic periodontal pathogen,Porphyromonas gingivalis. UbK1 contains conserved SPT/S, Hanks-type HxDxYR, EW, and Walker A motifs, and a mutation analysis established the Walker A domain and the Hanks-type domain as required for both autophosphorylation and transphosphorylation. UbK1 autophosphorylates on the proximal serine in the SPT/S domain as well as the tyrosine residue within the HxDxYR domain and the tyrosine residue immediately proximal, indicating both serine/threonine and tyrosine specificity. The orp...
Source: Molecular Oral Microbiology - July 21, 2021 Category: Microbiology Authors: John D. Perpich,
Lan Yakoumatos,
Parker Johns,
Kendall S. Stocke,
Zackary R. Fitzsimonds,
Daniel W. Wilkey,
Michael L. Merchant,
Daniel P. Miller,
Richard J. Lamont Tags: ORIGINAL ARTICLE Source Type: research
Identification and characterization of a UbK family kinase in Porphyromonas gingivalis which phosphorylates the RprY response regulator
This article is protected by copyright. All rights reserved (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - July 10, 2021 Category: Microbiology Authors: John D. Perpich,
Lan Yakoumatos,
Parker Johns,
Kendall S. Stocke,
Zackary R. Fitzsimonds,
Daniel W. Wilkey,
Michael L. Merchant,
Daniel P. Miller,
Richard J. Lamont Tags: ORIGINAL ARTICLE Source Type: research
Contribution of Adhesion Proteins to Aggregatibacter actinomycetemcomitans Biofilm Formation
This article is protected by copyright. All rights reserved (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - June 5, 2021 Category: Microbiology Authors: David R. Danforth,
Marcella Melloni,
Jake Tristano,
Keith P. Mintz Tags: ORIGINAL ARTICLE Source Type: research
The RagA and RagB proteins of Porphyromonas gingivalis
SummaryRagA and RagB proteins are major components of the outer membrane of the oral pathogenPorphyromonas gingivalis and, while recently suggested to represent a novel peptide uptake system, their full function is still under investigation. Herein, we (a) discuss the evidence that therag locus contributes toP. gingivalis virulence; (b) provide insight to Rag protein potential biological function in macromolecular transport and other aspects of bacterial physiology; (c) address the host response to Rag proteins which are immunodominant and immunomodulatory; and (d) review the potential of Rag-focused therapeutic strategies...
Source: Molecular Oral Microbiology - May 26, 2021 Category: Microbiology Authors: Jan Potempa,
Mariusz Madej,
David A Scott Tags: INVITED REVIEW Source Type: research
Issue Information
(Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - May 19, 2021 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research
Role of D ‐alanylation of Streptococcus mutans Lipoteichoic Acid in Interspecies Competitiveness
ConclusionD-Alanylation is involved in interspecies competitiveness ofS. mutans within oral biofilm by regulating mutacins and lactic acid production, which may modulate the profiles of dental biofilms. Results provide new insights into dental caries prevention and treatment. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - May 18, 2021 Category: Microbiology Authors: Minjing Wu,
Shan Huang,
Jingyun Du,
Shan Jiang,
Zhiyu Cai,
Ling Zhan,
Xiaojing Huang Tags: ORIGINAL ARTICLE Source Type: research
Zinc Import Mediated by AdcABC is Critical for Colonization of the Dental Biofilm by Streptococcus mutans in an Animal Model
In this study, we sought to identify and characterize the zinc uptake system(s) ofS. mutans, a keystone pathogen in dental caries and a causative agent of bacterial endocarditis. Different than other pathogenic bacteria, including several streptococci, that encode multiple zinc import systems, bioinformatic analysis indicated that theS. mutans core genome encodes a single, highly conserved, zinc importer commonly known as AdcABC. Inactivation of the genes coding for the metal ‐binding AdcA (ΔadcA) or both AdcC ATPase and AdcB permease ( ΔadcCB) severely impaired the ability ofS. mutans to grow under zinc ‐depleted co...
Source: Molecular Oral Microbiology - April 6, 2021 Category: Microbiology Authors: Tridib Ganguly,
Alexandra M. Peterson,
Jessica K. Kajfasz,
Jacqueline Abranches,
Jos é A. Lemos Tags: ORIGINAL ARTICLE Source Type: research
Platelet and Neutrophil Responses to Porphyromonas gingivalis in Human Whole Blood
This study evaluates the role ofP.gingivalis on platelet expression of CD62P, platelet ‐neutrophil interactions, and labeled neutrophil associated DNA. Human whole blood was preincubated with varyingP.gingivalis concentrations with or without subsequent addition of adenosine diphosphate (ADP). Flow cytometry was employed to measure CD62P expression in platelets using PerCP ‐anti‐CD61 and PE‐anti‐CD62P, platelet‐neutrophil interactions using PerCP‐anti‐CD61 and FITC‐anti‐CD16, and the release of neutrophil DNA using FITC‐anti‐CD16 and Sytox Blue labeling. Preincubation with high (6.25 x 106 CFU/mL) l...
Source: Molecular Oral Microbiology - April 3, 2021 Category: Microbiology Authors: William A. Chen,
Hansel M. Fletcher,
Kimberly J. Payne,
Sheryl Aka,
Melanie B. Thornburg,
Joseph D. Gheorghe,
Shahnaj Binte Safi,
David Shavlik,
Udochukwu Oyoyo,
Danilo S. Boskovic Tags: ORIGINAL ARTICLE Source Type: research
TPCA ‐1 negatively regulates inflammation mediated by NF‐κB pathway in mouse chronic periodontitis model
AbstractThe dysregulation of immune system plays a crucial function in periodontitis development. Pro ‐inflammatory cytokines are thought to be critical for the generation and development of periodontitis. The enhanced activity of osteoclasts contributes to periodontitis pathogenesis. Nuclear factor‐κB (NF‐κB) signaling pathway directly enhances osteoclast differentiation and maturation. 2‐ [(aminocarbonyl)amino]‐5‐(4‐fluorophenyl)‐3‐thiophenecarboxamide (TPCA‐1) is a IκB kinases (IKK) inhibitor. This research aimed to investigate whether TPCA‐1 had influence on the pathogenesis of chronic periodon...
Source: Molecular Oral Microbiology - March 30, 2021 Category: Microbiology Authors: Bo Wang,
Shizhu Bai,
Jiang Wang,
Nan Ren,
Rui Xie,
Geng Cheng,
Yan Yu Tags: ORIGINAL ARTICLE Source Type: research
sRNA23392 packaged by Porphyromonas gingivalis outer membrane vesicles promotes oral squamous cell carcinomas migration and invasion by targeting desmocollin ‐2
In this study, we foundP. gingivalis OMVs promote the invasion and migration of OSCC cells in vitro. Further research showed that sRNA23392 was abundant inP. gingivalis OMVs and it promoted the invasion and migration of OSCC cells by targeting Desmocollin ‐2 (DSC2). DSC2, a desmosomal cadherin family member, has been found to be involved in tumor progression. sRNA23392 inhibitors attenuatedP. gingivalis OMV ‐induced migration and invasion of OSCC cells. Collectively, these findings are consistent with the hypothesis that sRNA23392 inP. gingivalis OMVs is a novel mechanism of the host ‐pathogen interaction, wherebyP. ...
Source: Molecular Oral Microbiology - March 25, 2021 Category: Microbiology Authors: Dongjuan Liu,
Sai Liu,
Junchao Liu,
Lei Miao,
Shuwei Zhang,
Yaping Pan Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - March 23, 2021 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research
