The RagA and RagB proteins of Porphyromonas gingivalis

SummaryRagA and RagB proteins are major components of the outer membrane of the oral pathogenPorphyromonas gingivalis and, while recently suggested to represent a novel peptide uptake system, their full function is still under investigation. Herein, we (a) discuss the evidence that therag locus contributes toP. gingivalis virulence; (b) provide insight to Rag protein potential biological function in macromolecular transport and other aspects of bacterial physiology; (c) address the host response to Rag proteins which are immunodominant and immunomodulatory; and (d) review the potential of Rag-focused therapeutic strategies for the control of periodontal diseases.
Source: Molecular Oral Microbiology - Category: Microbiology Authors: Tags: INVITED REVIEW Source Type: research