sRNA23392 packaged by Porphyromonas gingivalis outer membrane vesicles promotes oral squamous cell carcinomas migration and invasion by targeting desmocollin ‐2

In this study, we foundP. gingivalis OMVs promote the invasion and migration of OSCC cells in vitro. Further research showed that sRNA23392 was abundant inP. gingivalis OMVs and it promoted the invasion and migration of OSCC cells by targeting Desmocollin ‐2 (DSC2). DSC2, a desmosomal cadherin family member, has been found to be involved in tumor progression. sRNA23392 inhibitors attenuatedP. gingivalis OMV ‐induced migration and invasion of OSCC cells. Collectively, these findings are consistent with the hypothesis that sRNA23392 inP. gingivalis OMVs is a novel mechanism of the host ‐pathogen interaction, wherebyP. gingivalis promotes the invasion and migration of OSCC.

Source: Molecular Oral Microbiology - March 25, 2021 Category: Microbiology Authors: Dongjuan Liu, Sai Liu, Junchao Liu, Lei Miao, Shuwei Zhang, Yaping Pan Tags: ORIGINAL ARTICLE Source Type: research