Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Retraction Note: MEK/ERK pathway activation by insulin receptor isoform alteration is associated with the abnormal proliferation and differentiation of intestinal epithelial cells in diabetic mice
Mol Cell Biochem. 2024 Feb 26. doi: 10.1007/s11010-024-04969-3. Online ahead of print.NO ABSTRACTPMID:38407731 | DOI:10.1007/s11010-024-04969-3 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 26, 2024 Category: Biochemistry Authors: Hui Ouyang Hong-Sheng Yang Tao Yu Ti-Dong Shan Jie-Yao Li Can-Ze Huang Wa Zhong Zhong-Sheng Xia Qi-Kui Chen Source Type: research

Retraction Note: Lidocaine alleviates cytotoxicity-resistance in lung cancer A549/DDP cells via down-regulation of miR-21
Mol Cell Biochem. 2024 Feb 26. doi: 10.1007/s11010-024-04971-9. Online ahead of print.NO ABSTRACTPMID:38407732 | DOI:10.1007/s11010-024-04971-9 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 26, 2024 Category: Biochemistry Authors: Qing Yang Zhi Zhang Haixia Xu Chuangen Ma Source Type: research

Neutrophil extracellular traps: a catalyst for atherosclerosis
Mol Cell Biochem. 2024 Feb 24. doi: 10.1007/s11010-024-04931-3. Online ahead of print.ABSTRACTNeutrophil extracellular traps (NETs) are network-like structures released by activated neutrophils. They consist mainly of double-stranded DNA, histones, and neutrophil granule proteins. Continuous release of NETs in response to external stimuli leads to activation of surrounding platelets and monocytes/macrophages, resulting in damage to endothelial cells (EC) and vascular smooth muscle cells (VSMC). Some clinical trials have demonstrated the association between NETs and the severity and prognosis of atherosclerosis. Furthermore...
Source: Molecular and Cellular Biochemistry - February 24, 2024 Category: Biochemistry Authors: Yinyu Wang Cuiping Wang Jiayan Li Source Type: research

MYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1
This study explored the role of miR-7-5p in the progression of DLBCL and pursued the underlying mechanism. Quantitative real-time PCR and transfection of miRNA mimic and inhibitors were used to assess the effects of miR-7-5p on autophagy and apoptosis in SU-DHL-4 and SU-DHL-10 cells. Dual-luciferase reporter assay was used to identify target genes of miR-7-5p. Immunofluorescence, flow cytometry, and western blotting (WB) were performed to explore the underlying mechanism and downstream pathways of miR-7-5p and AMBRA1 in DLBCL cells. MiR-7-5p was upregulated in DLBCL cells. Luciferase reporter assays implicated AMBRA1 as a ...
Source: Molecular and Cellular Biochemistry - February 23, 2024 Category: Biochemistry Authors: Cuifen Zhang Ke Wang Jiahao Tao Chuangjie Zheng Linzhu Zhai Source Type: research

METTL3-mediated m6A modification of NORAD inhibits the ferroptosis of vascular smooth muscle cells to attenuate the aortic dissection progression in an YTHDF2-dependent manner
In conclusion, METTL3-mediated NORAD inhibited ferroptosis of VSMCs via the HUR/GPX4 axis and decelerated AAD progression, suggesting that NORAD may be an AD therapeutic target.PMID:38383916 | DOI:10.1007/s11010-024-04930-4 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 22, 2024 Category: Biochemistry Authors: Mingfang Liao Sili Zou Jianjin Wu Jun Bai Yandong Liu Kangkang Zhi Lefeng Qu Source Type: research

Role of AMP deaminase in diabetic cardiomyopathy
Mol Cell Biochem. 2024 Feb 22. doi: 10.1007/s11010-024-04951-z. Online ahead of print.ABSTRACTDiabetes mellitus is one of the major causes of ischemic and nonischemic heart failure. While hypertension and coronary artery disease are frequent comorbidities in patients with diabetes, cardiac contractile dysfunction and remodeling occur in diabetic patients even without comorbidities, which is referred to as diabetic cardiomyopathy. Investigations in recent decades have demonstrated that the production of reactive oxygen species (ROS), impaired handling of intracellular Ca2+, and alterations in energy metabolism are involved ...
Source: Molecular and Cellular Biochemistry - February 22, 2024 Category: Biochemistry Authors: Tetsuji Miura Hidemichi Kouzu Masaya Tanno Yuki Tatekoshi Atsushi Kuno Source Type: research

Aerobic exercise mitigates high-fat diet-induced cardiac dysfunction, pyroptosis, and inflammation by inhibiting STING-NLRP3 signaling pathway
Mol Cell Biochem. 2024 Feb 22. doi: 10.1007/s11010-024-04950-0. Online ahead of print.ABSTRACTObesity has been identified as an independent risk factor for cardiovascular disease. Recent reports have highlighted the significance of stimulator of interferon genes (STING)-NOD-like receptor protein 3 (NLRP3) signaling pathway mediated pyroptosis, and inflammation in cardiovascular disease. Previous studies have demonstrated that exercise training effectively prevents cardiac pyroptosis and inflammation in high-fat diet (HFD)-fed mice. However, it is currently unknown whether exercise reduces pyroptosis and inflammation in obe...
Source: Molecular and Cellular Biochemistry - February 22, 2024 Category: Biochemistry Authors: Zujie Xu Zheying Ma Xiaoqin Zhao Bing Zhang Source Type: research

Coronary microthrombi in the failing human heart: the role of von Willebrand factor and PECAM-1
Mol Cell Biochem. 2024 Feb 21. doi: 10.1007/s11010-024-04942-0. Online ahead of print.ABSTRACTThe recognition of microthrombi in the heart microcirculation has recently emerged from studies in COVID-19 decedents. The present study investigated the ultrastructure of coronary microthrombi in heart failure (HF) due to cardiomyopathies that are unrelated to COVID-19 infection. In addition, we have investigated the role of von Willebrand factor (VWF) and PECAM-1 in microthrombus formation. We used electron microscopy to investigate the occurrence of microthrombi in patients with HF due to dilated (DCM, n = 7), inflammatory (MYO...
Source: Molecular and Cellular Biochemistry - February 21, 2024 Category: Biochemistry Authors: Sawa Kostin Theodoros Giannakopoulos Manfred Richter Florian Krizanic Benjamin Sasko Oliver Ritter Nikolaos Pagonas Source Type: research

Identification of key genes of diabetic cardiomyopathy in hiPSCs-CMs based on bioinformatics analysis
In this study, bioinformatics analysis was used to predict DbCM-related gene targets. Published datasets from the NCBI Gene Expression Omnibus with accession numbers GSE62203 and GSE197850 were selected for analysis. Differentially expressed genes (DEGs) were identified by the online tool GEO2R. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the DAVID online database. Protein-protein interaction network construction and hub gene identification were performed using STRING and Cytoscape. We used 30 mM and 1 μM hydrocortisone-stimulated AC16 cells as an ...
Source: Molecular and Cellular Biochemistry - February 21, 2024 Category: Biochemistry Authors: Shuo An Hongchen Bi Xiaoli Luo Caiying Zhu Min Wang Aiming Pang Yujie Cui Source Type: research