METTL3-mediated m6A modification of NORAD inhibits the ferroptosis of vascular smooth muscle cells to attenuate the aortic dissection progression in an YTHDF2-dependent manner

In conclusion, METTL3-mediated NORAD inhibited ferroptosis of VSMCs via the HUR/GPX4 axis and decelerated AAD progression, suggesting that NORAD may be an AD therapeutic target.PMID:38383916 | DOI:10.1007/s11010-024-04930-4

Source: Molecular and Cellular Biochemistry - February 22, 2024 Category: Biochemistry Authors: Mingfang Liao Sili Zou Jianjin Wu Jun Bai Yandong Liu Kangkang Zhi Lefeng Qu Source Type: research