Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress
Mol Cell Biochem. 2023 Dec 25. doi: 10.1007/s11010-023-04902-0. Online ahead of print.ABSTRACTPhenotypic change of vascular smooth muscle cells (VSMCs) is the main contributor of vascular pathological remodeling in atherosclerosis. The endoplasmic reticulum (ER) is critical for maintaining VSMC function through elimination of misfolded proteins that impair VSMC cellular function. ER-associated degradation (ERAD) is an ER-mediated process that controls protein quality by clearing misfolded proteins. One of the critical regulators of ERAD is HRD1, which also plays a vital role in lipid metabolism. However, the function of HR...
Source: Molecular and Cellular Biochemistry - December 25, 2023 Category: Biochemistry Authors: Linli Wang Zhitao Ren Lin Wu Ximei Zhang Min Wang Haiming Niu Xuemin He Heting Wang Yanming Chen Guojun Shi Xiaoxian Qian Source Type: research

Relevance and mechanism of STAT3/miR-221-3p/Fascin-1 axis in EGFR TKI resistance of triple-negative breast cancer
Mol Cell Biochem. 2023 Dec 25. doi: 10.1007/s11010-023-04907-9. Online ahead of print.ABSTRACTThe epidermal growth factor receptor 1 (EGFR) plays a crucial role in the progression of various malignant tumors and is considered a potential target for treating triple-negative breast cancer (TNBC). However, the effectiveness of representative tyrosine kinase inhibitors (TKIs) used in EGFR-targeted therapy is limited in TNBC patients. In our study, we observed that the TNBC cell lines MDA-MB-231 and MDA-MB-468 exhibited resistance to Gefitinib. Treatment with Gefitinib caused an upregulation of Fascin-1 (FSCN1) protein expressi...
Source: Molecular and Cellular Biochemistry - December 25, 2023 Category: Biochemistry Authors: Lu-Lu Jin Hua-Jun Lu Jun-Kang Shao Yan Wang Shi-Ping Lu Bi-Fei Huang Gui-Nv Hu Hong-Chuan Jin Chao-Qun Wang Source Type: research

PTBP1 as a potential regulator of disease
Mol Cell Biochem. 2023 Dec 22. doi: 10.1007/s11010-023-04905-x. Online ahead of print.ABSTRACTPolypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in alternative splicing of precursor mRNA and RNA metabolism. PTBP1 is universally expressed in various tissues and binds to multiple downstream transcripts to interfere with physiological and pathological processes such as the tumor growth, body metabolism, cardiovascular homeostasis, and central nervous system damage, showing great prospects in many fields. The function of PTBP1 involve...
Source: Molecular and Cellular Biochemistry - December 22, 2023 Category: Biochemistry Authors: Qi Yu Tongtong Wu Wenhong Xu Junyuan Wei Anqi Zhao Miaomiao Wang Meiying Li Guangfan Chi Source Type: research

The predictive value of the neutrophil/platelet ratio on in-hospital adverse events and long-term prognosis in patients with coronary artery disease after percutaneous coronary intervention and its possible internal mechanism
Mol Cell Biochem. 2023 Dec 22. doi: 10.1007/s11010-023-04901-1. Online ahead of print.ABSTRACTThe neutrophil-to-platelet ratio (NPR) is considered to be an indicator of inflammatory status. The value of the NPR in predicting in-hospital adverse events (AEs) and long-term prognosis after percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients has not yet been reported. Meanwhile, the mechanisms behind its predictive value for long-term prognosis remain unreported as well. The study retrospectively enrolled 7284 consecutive patients with CAD undergoing PCI from January 2012 to December 2018. Multiv...
Source: Molecular and Cellular Biochemistry - December 22, 2023 Category: Biochemistry Authors: Yifei Xiang Jilang Zeng Xueqin Lin Xiaoling Cai Liwei Zhang Manqing Luo Gengyu Zhou Xiaofang Chen Biting Lin Junhan Chen Fan Chen Xuan Huang Yansong Guo Kai-Yang Lin Source Type: research