Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

ACSL4 accelerates osteosarcoma progression via modulating TGF- β/Smad2 signaling pathway
In this study, we investigated the expression of ACSL4 in OS tissues using immunohistochemistry staining (IHC) staining of a human tissue microarray and in OS cells by qPCR assay. Our findings revealed a significant up-regulation of ACSL4 in both OS tissues and cells. To further understand its biological effects, we conducted a series of loss-of-function experiments using ACSL4-depleted MNNG/HOS and U-2OS cell lines, focusing on OS cell proliferation, migration, and apoptosis in vitro. Our results demonstrated that ACSL4 knockdown remarkably suppressed OS cell proliferation, arrested cells in the G2 phase, induced cell apo...
Source: Molecular and Cellular Biochemistry - April 2, 2024 Category: Biochemistry Authors: Xiaofeng Li Qianfen Chen Duo Zhao Jianshi Tan Rongbo Liao Yurong Gu Jinwei Zhu Huying Zhang Jian Xie Lu Chen Source Type: research

Protein kinase D2-Aurora kinase A-ERK1/2 signalling axis drives neuroendocrine differentiation of epithelial ovarian cancer
We report that Aurora kinase A drives NED of epithelial ovarian cancer in an ERK1/2-dependent manner and pharmacological and genetic inhibition of Aurora kinase A suppress NED of ovarian cancer. Moreover, we demonstrate that protein kinase D2 positively regulated Aurora kinase A to drive NED. Overexpression of catalytically active PKD2 drives NED and collectively, PKD2 cross talks with Aurora kinase A/ERK1/2 signalling axis to positively regulate NED of EOC. PKD2/Aurora kinase A/ERK1/2 signalling axis is a novel therapeutic target against neuroendocrine differentiated EOC.PMID:38557789 | DOI:10.1007/s11010-024-04986-2 (Sou...
Source: Molecular and Cellular Biochemistry - April 1, 2024 Category: Biochemistry Authors: Abha Sachdeva Adhiraj Roy Supratim Mandal Source Type: research

Ferroptosis in organ ischemia-reperfusion injuries: recent advancements and strategies
This article provides a comprehensive overview underlying the mechanisms of ferroptosis, with a further focus on the latest research progress regarding interference with ferroptotic pathways in organ I/R injuries, such as intestine, lung, heart, kidney, liver, and brain. Understanding the links between ferroptosis and I/R injury may inform potential therapeutic strategies and targeted agents.PMID:38556592 | DOI:10.1007/s11010-024-04978-2 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - March 31, 2024 Category: Biochemistry Authors: Xiaoyu Luan Peng Chen Longyu Miao Xinying Yuan Chaoqun Yu Guohu Di Source Type: research

PCSK5 downregulation promotes the inhibitory effect of andrographolide on glioblastoma through regulating STAT3
Mol Cell Biochem. 2024 Mar 29. doi: 10.1007/s11010-024-04977-3. Online ahead of print.ABSTRACTProprotein convertase subtilisin/kexin type 5 (PCSK5) is a member of the proprotein convertase (PC) family, which processes immature proteins into functional proteins and plays an important role in the process of cell migration and transformation. Andrographolide is a non-peptide compound with PC inhibition and antitumor activity. Our research aimed to investigate the functional role of PCSK5 downregulation combined with Andro on GBM progression. Results from the cancer genome atlas (TCGA) and clinical samples revealed a significa...
Source: Molecular and Cellular Biochemistry - March 30, 2024 Category: Biochemistry Authors: Huiyuan Gong Xiaomin Yang Lijun An Wangming Zhang Xiaohua Liu Liping Shu Liuqi Yang Source Type: research

Folate induces stemness and increases oxygen consumption under glucose deprivation by notch-1 pathway activation in colorectal cancer cell
Mol Cell Biochem. 2024 Mar 27. doi: 10.1007/s11010-024-04987-1. Online ahead of print.ABSTRACTEvidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies. The Not...
Source: Molecular and Cellular Biochemistry - March 27, 2024 Category: Biochemistry Authors: Juan Rodr íguez Silva Mat ías Monsalves-Álvarez Carlos Sep úlveda Camila Donoso-Barraza Rodrigo Troncoso Sandra Hirsch Source Type: research

Correction to: Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
Mol Cell Biochem. 2024 Mar 27. doi: 10.1007/s11010-024-04998-y. Online ahead of print.NO ABSTRACTPMID:38536556 | DOI:10.1007/s11010-024-04998-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - March 27, 2024 Category: Biochemistry Authors: Shan Gao Qiaochu Cheng Yaguang Hu Xiaojuan Fan Chen Liang Chen Niu Qianyan Kang Ting Wei Source Type: research

Intermittent fasting shifts the diurnal transcriptome atlas of transcription factors
Mol Cell Biochem. 2024 Mar 25. doi: 10.1007/s11010-024-04928-y. Online ahead of print.ABSTRACTIntermittent fasting remains a safe and effective strategy to ameliorate various age-related diseases, but its specific mechanisms are not fully understood. Considering that transcription factors (TFs) determine the response to environmental signals, here, we profiled the diurnal expression of 600 samples across four metabolic tissues sampled every 4 over 24 h from mice placed on five different feeding regimens to provide an atlas of TFs in biological space, time, and feeding regimen. Results showed that 1218 TFs exhibited tissue-...
Source: Molecular and Cellular Biochemistry - March 26, 2024 Category: Biochemistry Authors: Min Fu Siyu Lu Lijun Gong Yiming Zhou Fang Wei Zhigui Duan Rong Xiang Frank J Gonzalez Guolin Li Source Type: research

Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer
In this study, we provide an overview of the JAK-STAT pathway, delving into the composition, activation, and dynamic interplay within the pathway. Additionally, we focus on the molecular mechanisms driving the aberrant activation of the JAK-STAT pathway in LC. Furthermore, we summarize the latest advancements in targeting the JAK-STAT pathway for LC treatment. The insights presented in this review aim to underscore the necessity of research into the JAK-STAT signaling pathway as a promising avenue for LC therapy.PMID:38519710 | DOI:10.1007/s11010-024-04983-5 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - March 23, 2024 Category: Biochemistry Authors: JunJun Jia Xuelian Zhou Qingfei Chu Source Type: research