Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ferroptosis: a new promising target for hepatocellular carcinoma therapy
Mol Cell Biochem. 2023 Dec 5. doi: 10.1007/s11010-023-04893-y. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the sixed most common malignant tumor in the world. The study for HCC is mired in the predicament confronted with the difficulty of early diagnosis and high drug resistance, the survival rate of patients with HCC being low. Ferroptosis, an iron-dependent cell death, has been discovered in recent years as a cell death means with tremendous potential to fight against cancer. The in-depth researches for iron metabolism, lipid peroxidation and dysregulation of antioxidant defense have brought about tan...
Source: Molecular and Cellular Biochemistry - December 5, 2023 Category: Biochemistry Authors: Qiaoping Xu Lanqi Ren Ning Ren Yibei Yang Junjie Pan Yu Zheng Gang Wang Source Type: research

Disrupting of IGF2BP3-stabilized HK2 mRNA by MYO16-AS1 competitively binding impairs LUAD migration and invasion
Mol Cell Biochem. 2023 Dec 2. doi: 10.1007/s11010-023-04887-w. Online ahead of print.ABSTRACTSince invasive cancer is associated with poor clinical outcomes, exploring the molecular mechanism underlying LUAD progression is crucial to improve the prognosis of patients with advanced disease. Herein, we found that MYO16-AS1 is expressed mainly in lung tissue but is notably downregulated in LUAD tissues. Overexpression of MYO16-AS1 inhibited the migration and invasion of LUAD cells. Mechanistic studies indicated that H3K27Ac modification mediated MYO16-AS1 transcription. Furthermore, we found that MYO16-AS1 competitively bound...
Source: Molecular and Cellular Biochemistry - December 2, 2023 Category: Biochemistry Authors: Peiwei Li Haibo Ge Jiangfeng Zhao Yongjia Zhou Jie Zhou Peichao Li Junwen Luo Wenhao Zhang Zhongxian Tian Xiaogang Zhao Source Type: research

Retraction Note to: Mesothelial cells differentiate into fibroblast-like cells under the scirrhous gastric cancer microenvironment and promote peritoneal carcinomatosis in vitro and in vivo
Mol Cell Biochem. 2023 Dec 1. doi: 10.1007/s11010-023-04911-z. Online ahead of print.NO ABSTRACTPMID:38038799 | DOI:10.1007/s11010-023-04911-z (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - December 1, 2023 Category: Biochemistry Authors: Zhi-Dong Lv Hai-Bo Wang Qian Dong Bin Kong Jian-Guo Li Zhao-Chuan Yang Hui-Li Qu Wei-Hong Cao Hui-Mian Xu Source Type: research

Spermidine protects cartilage from IL-1 β-mediated ferroptosis
Mol Cell Biochem. 2023 Dec 2. doi: 10.1007/s11010-023-04889-8. Online ahead of print.ABSTRACTRheumatoid arthritis is characterized by a burst of inflammation, the destruction of cartilage and the abundant release of inflammatory factors such as IL-1β. Thus, the effect of IL-1β on cartilage was examined in this study. IL-1β could cause lipid peroxidation and disturbances in iron metabolism by increasing the expression of NCOA4 and decreasing the expression of FTH, which also induced ferritinophagy. In addition, the expression of the key antioxidant proteins SLC7A11 and GPX4 was inhibited by IL-1β, resulting in ferroptos...
Source: Molecular and Cellular Biochemistry - December 1, 2023 Category: Biochemistry Authors: Qi Cheng Li Ni Ang Liu Xiaoxiong Huang Pan Xiang Qin Zhang Huilin Yang Source Type: research

TCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling
Mol Cell Biochem. 2023 Nov 29. doi: 10.1007/s11010-023-04891-0. Online ahead of print.ABSTRACTGlioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, the association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinformatics, showing significant relationships with age, WHO grade, IDH, and 1p/19q status, as well as being an independent predictor of prognosis. Immunohistochemistry of a glioma sample microarray showed markedly increased TCAF2 expression in glioblastoma relative to lower-grade glioma, with elevated expression predominating in...
Source: Molecular and Cellular Biochemistry - November 29, 2023 Category: Biochemistry Authors: Debo Yun Jianshen Liang Xuya Wang Jikang Fan Xisen Wang Jiabo Li Xiao Ren Jie Liu Xiude Ren Hao Zhang Guanjie Shang Wenzhe Jin Lei Chen Tao Li Chen Zhang Shengping Yu Xuejun Yang Source Type: research

Fer-mediated activation of the Ras-MAPK signaling pathway drives the proliferation, migration, and invasion of endometrial carcinoma cells
CONCLUSION: In summary, the upregulation of Fer in EC cells resulted in the enhancement of cell proliferation, migration, and invasion through the activation of the Ras-MAPK signaling pathway.PMID:38017327 | DOI:10.1007/s11010-023-04890-1 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - November 28, 2023 Category: Biochemistry Authors: Lifan Shen Chen Zhang Kaiying Cui Xin Liang Genhai Zhu Lan Hong Source Type: research

Retraction Note: Role of CC-chemokine receptor 5 on myocardial ischemia-reperfusion injury in rats
Mol Cell Biochem. 2023 Nov 25. doi: 10.1007/s11010-023-04897-8. Online ahead of print.NO ABSTRACTPMID:38006540 | DOI:10.1007/s11010-023-04897-8 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - November 25, 2023 Category: Biochemistry Authors: Bo Shen Jun Li Ling Gao Jieyu Zhang Bo Yang Source Type: research

Retraction Note: Protein kinase catalytic subunit (PKAcat) from bovine lens: purification, characterization and phosphorylation of lens crystallins
Mol Cell Biochem. 2023 Nov 25. doi: 10.1007/s11010-023-04896-9. Online ahead of print.NO ABSTRACTPMID:38006541 | DOI:10.1007/s11010-023-04896-9 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - November 25, 2023 Category: Biochemistry Authors: Bhaswati Samanta Subir Kumar Nagdas Kalipada Das Parimal Chandra Sen Source Type: research