Molecular and Cellular Biochemistry 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Retraction Note: Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/ β-catenin pathway
Mol Cell Biochem. 2024 Feb 8. doi: 10.1007/s11010-024-04959-5. Online ahead of print.NO ABSTRACTPMID:38329637 | DOI:10.1007/s11010-024-04959-5 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 8, 2024 Category: Biochemistry Authors: Yanyan Cui Luyu Zhang Wenjie Wang Shanshan Ma Hongtao Liu Xingxing Zang Yanting Zhang Fangxia Guan Source Type: research
ER stress improvement by aerobic training or enalapril differently ameliorates pathological cardiac remodeling in obese mice
Mol Cell Biochem. 2024 Feb 3. doi: 10.1007/s11010-024-04925-1. Online ahead of print.ABSTRACTOveractivation of the classic arm of the renin-angiotensin system (RAS) is one of the main mechanisms involved in obesity-related cardiac remodeling, and a possible relationship between RAS and ER stress in the cardiovascular system have been described. Thus, the aim of this study is to evaluate if activating the protective arm of the RAS by ACE inhibition or aerobic exercise training could overturn diet-induced pathological cardiac hypertrophy by attenuating ER stress. Male C57BL/6 mice were fed a control (SC) or a high-fat diet (...
Source: Molecular and Cellular Biochemistry - February 3, 2024 Category: Biochemistry Authors: Amanda Concei ção Pimenta Salles Beatriz Alexandre-Santos Thais de Souza Carvalho Ana Beatriz Proen ça Vinicius Sep úlveda-Fragoso Tiago Fernandes Edilamar Menezes Oliveira Antonio Claudio Lucas da N óbrega Eliete Dalla Corte Frantz D'Angelo Carlo Ma Source Type: research
The frequency of the ACE I/D polymorphism in South America: a systematic review and meta-analysis
This study aimed to verify the allelic predominance and genotype frequency of ACE I/D polymorphism in South America and its association with the main diseases and related conditions. We conducted a systematic review considering studies published in the last 25 years available in PubMed, Scielo, LILACS, LIPECS, Coleciona SUS, CUMED, BINACIS, IBECS, and MEDLINE databases, resulting in the inclusion of 121 studies. Quality of the studies was assessed according to the Strengthening the Reporting of Genetic Association (STREGA) guidelines. We mapped the frequency of the ACE I/D polymorphism in South American populations. 8,856 ...
Source: Molecular and Cellular Biochemistry - February 3, 2024 Category: Biochemistry Authors: Rebeca Gon çalves Trevisano Helen Matias Thais de Jesus Teani Valmir Oliveira Silvino Cirley Pinheiro Ferreira Marcos Antonio Pereira Dos Santos Pedro Luiz Garcia Braga Sandro Soares Almeida Source Type: research
ALKBH5 facilitates the progression of infantile hemangioma by increasing FOXF1 expression in a m < sup > 6 < /sup > A-YTHDF2 dependent manner to activate HK-2 signaling
Mol Cell Biochem. 2024 Feb 2. doi: 10.1007/s11010-024-04936-y. Online ahead of print.ABSTRACTAlkylation repair homolog protein 5 (ALKBH5) is reported to participate in infantile hemangioma (IH) progression. However, the underlying mechanism of ALKBH5 in IH remains unclear. Using qRT-PCR and Western blotting, ALKBH5, forkhead box F1 (FOXF1) and hexokinase 2 (HK-2) expressions in IH tissues and IH-derived endothelial cells XPTS-1 were assessed. The Me-RIP assay was used to analyze FOXF1 m6A level. CCK8, colony formation, flow cytometry and transwell assays were employed to determine IH cell viability, proliferation, apoptosi...
Source: Molecular and Cellular Biochemistry - February 2, 2024 Category: Biochemistry Authors: Kun Peng Ren-Peng Xia Fan Zhao Yong Xiao Ti-Dong Ma Ming Li Yong Feng Chong-Gao Zhou Source Type: research
Non-coding RNAs and angiogenesis in cardiovascular diseases: a comprehensive review
Mol Cell Biochem. 2024 Feb 2. doi: 10.1007/s11010-023-04919-5. Online ahead of print.ABSTRACTNon-coding RNAs (ncRNAs) have key roles in the etiology of many illnesses, including heart failure, myocardial infarction, stroke, and in physiological processes like angiogenesis. In transcriptional regulatory circuits that control heart growth, signaling, and stress response, as well as remodeling in cardiac disease, ncRNAs have become important players. Studies on ncRNAs and cardiovascular disease have made great progress recently. Here, we go through the functions of non-coding RNAs (ncRNAs) like circular RNAs (circRNAs), and m...
Source: Molecular and Cellular Biochemistry - February 2, 2024 Category: Biochemistry Authors: Jie Zhang Source Type: research
TRPM2 knockdown attenuates myocardial apoptosis and promotes autophagy in HFD/STZ-induced diabetic mice via regulating the MEK/ERK and mTORC1 signaling pathway
Mol Cell Biochem. 2024 Feb 3. doi: 10.1007/s11010-024-04926-0. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a major complication of diabetes. Transient receptor potential melastatin 2 (TRPM2) activity increases in diabetic oxidative stress state, and it is involved in myocardial damage and repair. We explore the protective effect of TRPM2 knockdown on the progression of DCM. A type 2 diabetes animal model was established in C57BL/6N mice by long-term high-fat diet (HFD) feeding combined with a single injection of 100-mg/kg streptozotocin (STZ). Genetic knockdown of TRPM2 in heart was accomplished by the i...
Source: Molecular and Cellular Biochemistry - February 2, 2024 Category: Biochemistry Authors: Feng Hu Chaoyang Lin Source Type: research
Inhibitors of gastric acid secretion increase oxidative stress and matrix metalloproteinase-2 activity leading to vascular remodeling
This study aimed at examining whether treatment with the H2RB ranitidine promotes oxidative stress resulting in vascular MMP activation and corresponding functional and structural alterations in the vasculature, as compared with those found with the PPI omeprazole. Male Wistar rats were treated (4 weeks) with vehicle (2% tween 20), omeprazole (10 mg/Kg/day; i.p.) or ranitidine (100 mg/Kg/day; gavage). Then the aorta was collected to perform functional, biochemical, and morphometric analysis. Both ranitidine and omeprazole increased gastric pH and oxidative stress assessed in situ with the fluorescent dye dihydroethidium (D...
Source: Molecular and Cellular Biochemistry - February 1, 2024 Category: Biochemistry Authors: Renato C Nogueira J éssica M Sanches-Lopes Gustavo H Oliveira-Paula Jose E Tanus-Santos Source Type: research
Vitamin D accelerates the subdural hematoma clearance through improving the meningeal lymphatic vessel function
Mol Cell Biochem. 2024 Jan 31. doi: 10.1007/s11010-023-04918-6. Online ahead of print.ABSTRACTSubdural hematoma (SDH) drains into the extracranial lymphatic system through the meningeal lymphatic vessels (mLVs) but the formation of SDH impairs mLVs. Because vitamin D (Vit D) can protect the endothelial cells, we hypothesized that Vit D may enhance the SDH clearance. SDH was induced in Sprague-Dawley rats and treated with Vit D or vehicle. Hematoma volume in each group was measured by H&E staining and hemoglobin quantification. Evans blue (EB) quantification and red blood cells injection were used to evaluated the drain...
Source: Molecular and Cellular Biochemistry - January 31, 2024 Category: Biochemistry Authors: Yupeng Chen Xuanhui Liu Jiangyuan Yuan Shiying Dong Meng Nie Weiwei Jiang Di Wu Mingqi Liu Tao Liu Chenrui Wu Chuang Gao Jianning Zhang Rongcai Jiang Source Type: research
Retraction Note: Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF- кB signaling
Mol Cell Biochem. 2024 Jan 29. doi: 10.1007/s11010-024-04941-1. Online ahead of print.NO ABSTRACTPMID:38285381 | DOI:10.1007/s11010-024-04941-1 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - January 29, 2024 Category: Biochemistry Authors: Tianbao Lai Liangyi Chen Xingyu Chen Jianquan He Peiyu Lv Hua Ge Source Type: research
Apigenin accelerates wound healing in diabetic mice by promoting macrophage M2-type polarization via increasing miR-21 expression
Mol Cell Biochem. 2024 Jan 23. doi: 10.1007/s11010-023-04885-y. Online ahead of print.ABSTRACTThe alteration of inflammatory phenotype by macrophage polarization plays an important role in diabetic wound repair. Apigenin has been reported to be anti-inflammatory and promote tissue repair; however, whether it regulates macrophage polarization to participate in diabetic wound repair remains to be investigated. We found that apigenin promoted miR-21 expression in LPS-stimulated RAW264.7 cells, inhibited cellular M1-type factor TNF-α and IL-1β secretion and increased M2-type factor IL-10 and TGF-β secretion, and accelerated...
Source: Molecular and Cellular Biochemistry - January 23, 2024 Category: Biochemistry Authors: Ke Li Lijun Wu Jingting Jiang Source Type: research
The role of WWP1 and WWP2 in bone/cartilage development and diseases
Mol Cell Biochem. 2024 Jan 22. doi: 10.1007/s11010-023-04917-7. Online ahead of print.ABSTRACTBone and cartilage diseases are often associated with trauma and senescence, manifested as pain and limited mobility. The repair of bone and cartilage lesion by mesenchymal stem cells is regulated by various transcription factors. WW domain-containing protein 1 (WWP1) and WW domain-containing protein 2 (WWP2) are named for WW domain which recognizes PPXY (phono Ser Pro and Pro Arg) motifs of substrate. WWP1and WWP2 are prominent components of the homologous to the E6-AP carboxyl terminus (HECT) subfamily, a group of the ubiquitin ...
Source: Molecular and Cellular Biochemistry - January 22, 2024 Category: Biochemistry Authors: Ying Wang Zuping Wu Cunyi Wang Na Wu Chenyu Wang Shiyu Hu Jiejun Shi Source Type: research
Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer
Mol Cell Biochem. 2024 Jan 16. doi: 10.1007/s11010-023-04914-w. Online ahead of print.ABSTRACTSeveral commercially available triorganotin compounds were previously found to function as agonist ligands for nuclear retinoid X receptor (RXR) molecules. Triphenyltin isoselenocyanate (TPT-NCSe), a novel selenium atom containing a derivative of triorganotin origin, was found to represent a new cognate bioactive ligand for RXRs. TPT-NCSe displayed a concentration- and time-dependent decrease in the cell viability in both human breast carcinoma MCF-7 (estrogen receptor positive) and MDA‑MB‑231 (triple negative) cell lines. Rea...
Source: Molecular and Cellular Biochemistry - January 16, 2024 Category: Biochemistry Authors: Dana Macejova Jakub Kollar Pavel Bobal Jan Otevrel Daniela Schuster Julius Brtko Source Type: research
Bone morphogenetic protein-2 and pulsed electrical stimulation synergistically promoted osteogenic differentiation on MC-3T3-E1 cells
In this study, the osteogenic regulation of MC-3T3-E1 cells was studied by combining pulsed electrical stimulation (PES) and different concentrations of BMP-2. The results showed that PES and BMP-2 could synergically promote the proliferation of MC-3T3-E1 cells. The qPCR results of osteoblast-related genes showed that PES was synergistic with BMP-2 to promote osteoblast differentiation mainly through the regulation of the Smad/BMP and insulin like growth factor 1 (IGF1) signaling pathways. The expression level of alkaline phosphatase (ALP) and alizarin red staining further demonstrated the synergistic effect of PES and BMP...
Source: Molecular and Cellular Biochemistry - January 16, 2024 Category: Biochemistry Authors: Shaodong Xie Deming Zeng Hanwen Luo Ping Zhong Yu Wang Zhiqiang Xu Peibiao Zhang Source Type: research
Long-chain polyunsaturated fatty acids influence colorectal cancer progression via the interactions between the intestinal microflora and the macrophages
Mol Cell Biochem. 2024 Jan 13. doi: 10.1007/s11010-023-04904-y. Online ahead of print.ABSTRACTThe metabolism of long-chain polyunsaturated fatty acids (LCPUFAs) is closely associated with the risk and progression of colorectal cancer (CRC). This paper aims to investigate the role of LCPUFA in the crosstalk between intestinal microflora and macrophages, as well as the effects of these three parties on the progression of CRC. The metabolism and function of LCPUFA play important roles in regulating the composition of the human gut microflora and participating in the regulation of inflammation, ultimately affecting macrophage ...
Source: Molecular and Cellular Biochemistry - January 13, 2024 Category: Biochemistry Authors: Duo Peng Yan Wang Yunhong Yao Zisha Yang Shuang Wu Kaijing Zeng Xinrong Hu Yi Zhao Source Type: research
The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy
Mol Cell Biochem. 2024 Jan 8. doi: 10.1007/s11010-023-04909-7. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) represents a distinct myocardial disorder elicited by diabetes mellitus, characterized by aberrations in myocardial function and structural integrity. This pathological condition predominantly manifests in individuals with diabetes who do not have concurrent coronary artery disease or hypertension. An escalating body of scientific evidence substantiates the pivotal role of programmed cell death (PCD)-encompassing apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis-in the pathogenic progressi...
Source: Molecular and Cellular Biochemistry - January 8, 2024 Category: Biochemistry Authors: Bingrui Zhang Hua Wu Jingwen Zhang Cong Cong Lin Zhang Source Type: research
