Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

NEK2 affects the ferroptosis sensitivity of gastric cancer cells by regulating the expression of HMOX1 through Keap1/Nrf2
This study confirmed that NEK2 can regulate HMOX1 expression through Keap1/Nrf2 signal, and then affect the sensitivity of gastric cancer cells to ferroptosis, enriching the role and mechanism of NEK2 in gastric cancer.PMID:38503948 | DOI:10.1007/s11010-024-04960-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - March 20, 2024 Category: Biochemistry Authors: Jianyong Wu Desheng Luo Laizhen Tou Hongtao Xu Chuan Jiang Dan Wu Haifeng Que Jingjing Zheng Source Type: research

STK32C modulates doxorubicin resistance in triple-negative breast cancer cells via glycolysis regulation
Mol Cell Biochem. 2024 Mar 20. doi: 10.1007/s11010-024-04989-z. Online ahead of print.ABSTRACTUnderstanding the mechanisms underlying doxorubicin resistance in triple-negative breast cancer (TNBC) holds paramount clinical significance. In our study, we investigate the potential of STK32C, a little-explored kinase, to impact doxorubicin sensitivity in TNBC cells. Our findings reveal elevated STK32C expression in TNBC specimens, associated with unfavorable prognosis in doxorubicin-treated TNBC patients. Subsequent experiments highlighted that STK32C depletion significantly augmented the sensitivity of doxorubicin-resistant T...
Source: Molecular and Cellular Biochemistry - March 20, 2024 Category: Biochemistry Authors: Huawei Xiao Lei Liu Shaoyan Huang Source Type: research

Combinational delivery of TLR4 and TLR7/8 agonist enhanced the therapeutic efficacy of immune checkpoint inhibitors to colon tumor
Mol Cell Biochem. 2024 Mar 20. doi: 10.1007/s11010-024-04966-6. Online ahead of print.ABSTRACTImmunotherapy is regarded as a potent cancer treatment, with DC vaccines playing a crucial role. Although clinical trials have demonstrated the safety and efficacy of DC vaccines, loading antigens in vitro is challenging, and their therapeutic effects remain unpredictable. Moreover, the diverse subtypes and maturity states of DCs in the body could induce both immune responses and immune tolerance, potentially affecting the vaccine's efficacy. Hence, the optimization of DC vaccines remains imperative. Our study discovered a new the...
Source: Molecular and Cellular Biochemistry - March 20, 2024 Category: Biochemistry Authors: Mengjiao Wang Quan Wan Chenglv Wang Qianyu Jing Yujie Nie Xiangyan Zhang Xin Chen De Yang Runsang Pan Linzhao Li Lan Zhu Huan Gui Shuanghui Chen Yuezhen Deng Tao Chen Yingjie Nie Source Type: research

Investigation of homocysteine, D-dimer and platelet count levels as potential predictors of thrombosis risk in COVID-19 patients
This study aimed to investigate the relationship between homocysteine, a thrombosis-related biomarker, and other thrombosis-related parameters, such as D-dimer and platelet count with disease outcome in COVID-19 patients. This case-control study including 50 intensive care unit hospitalized patients with Covid-19 with a positive RT-PCR test for SARS-CoV-2 infection and 50 healthy individuals as a control group was conducted. Both groups were matched for age and body mass index (BMI) and had no history of underlying diseases such as cardiovascular, liver, kidney or smoking. Blood samples were collected from both groups to m...
Source: Molecular and Cellular Biochemistry - March 19, 2024 Category: Biochemistry Authors: Zahra Eslamifar Mahin Behzadifard Ehsan Zare Source Type: research

Disturbances in mitochondrial bioenergetics and control quality and unbalanced redox homeostasis in the liver of a mouse model of mucopolysaccharidosis type II
Mol Cell Biochem. 2024 Mar 18. doi: 10.1007/s11010-024-04952-y. Online ahead of print.ABSTRACTMucopolysaccharidosis type II (MPS II; Hunter syndrome) is a lysosomal storage disease caused by mutations in the gene encoding the enzyme iduronate 2-sulfatase (IDS) and biochemically characterized by the accumulation of glycosaminoglycans (GAGs) in different tissues. It is a multisystemic disorder that presents liver abnormalities, the pathophysiology of which is not yet established. In the present study, we evaluated bioenergetics, redox homeostasis, and mitochondrial dynamics in the liver of 6-month-old MPS II mice (IDS-). Our...
Source: Molecular and Cellular Biochemistry - March 18, 2024 Category: Biochemistry Authors: Camila Vieira Pinheiro Rafael Teixeira Ribeiro Ana Cristina Roginski Morgana Brondani Ângela Beatris Zemniaçak Chr ístofer Ian Hernandez Hoffmann Alexandre Umpierrez Amaral Moacir Wajner Guilherme Baldo Guilhian Leipnitz Source Type: research

Abnormal upregulation of NUBP2 contributes to cancer progression in colorectal cancer
In this study, we found that NUBP2 was highly expressed in CRC by TCGA database analysis. Subsequently, we verified the expression of NUBP2 in CRC tumor tissues and para-carcinoma tissues using IHC staining, and further investigated its association with clinicopathological parameters. In vitro cell experiments were conducted to assess the role of NUBP2 in CRC by evaluating cell proliferation, migration, and apoptosis upon NUBP2 dysregulation. Furthermore, we established a subcutaneous CRC model to evaluate the impact of NUBP2 on tumor growth in vivo. Additionally, we performed mechanistic exploration using a Human Phospho-...
Source: Molecular and Cellular Biochemistry - March 16, 2024 Category: Biochemistry Authors: Danfeng Lan Junyu Wang Guishun Sun Lixia Jiang Qiyun Chen Sha Li Haiyan Qu Yibo Wang Bian Wu Source Type: research

Untargeted metabolomics identifies indole-3-propionic acid to relieve Ang II-induced endothelial dysfunction in aortic dissection
Mol Cell Biochem. 2024 Mar 14. doi: 10.1007/s11010-024-04961-x. Online ahead of print.ABSTRACTIndole-3-propionic acid (IPA), a gut microbiota-derived metabolite of tryptophan, has been proven to fulfill an essential function in cardiovascular disease (CVD) and nerve regeneration disease. However, the role of IPA in aortic dissection (AD) has not been revealed. We aimed to investigate the role of IPA in the pathogenesis of AD and the underlying mechanisms of IPA in endothelial dysfunction. Untargeted metabolomics has been employed to screen the plasma metabolic profile of AD patients in comparison with healthy individuals. ...
Source: Molecular and Cellular Biochemistry - March 15, 2024 Category: Biochemistry Authors: Qi Wang Hui Lv Mierxiati Ainiwan Gulinazi Yesitayi Asiya Abudesimu Dilixiati Siti Aliya Aizitiaili Xiang Ma Source Type: research

miR-575/RIPK4 axis modulates cell cycle progression and proliferation by inactivating the Wnt/ β-catenin signaling pathway through inhibiting RUNX1 in colon cancer
Mol Cell Biochem. 2024 Mar 14. doi: 10.1007/s11010-024-04938-w. Online ahead of print.ABSTRACTReceptor interacting protein serine/threonine kinase 4 (RIPK4) is widely involved in human cancer development. Nevertheless, its role in colon cancer (COAD) has not been elucidated till now. Our research aimed at exploring the function and underlying molecular mechanism of RIPK4 in COAD progression. Through bioinformatic analyses and RT-qPCR, RIPK4 was discovered to be increased in COAD cells and tissues, and its high level predicted poor prognosis. Loss-of-function assays revealed that RIPK4 silencing suppressed COAD cell growth,...
Source: Molecular and Cellular Biochemistry - March 14, 2024 Category: Biochemistry Authors: Qun Wang Weijun Lu Li Lu Ruopu Wu Dongde Wu Source Type: research

LncRNA MCM3AP-AS1 promotes chemoresistance in triple-negative breast cancer through the miR-524-5p/RBM39 axis
This study investigated the action of MCM3AP-AS1 in chemoresistance of TNBC cells. Drug-resistant TNBC cell lines SUM159PTR and MDA-MB-231R were constructed by exposure to increasing concentrations of doxorubicin/docetaxel (DOX/DXL). MCM3AP-AS1 and miR-524-5p expression levels were determined by RT-qPCR. RNA binding motif 39 (RBM39) level was measured using Western blot. Cell viability and apoptosis were assessed by CCK-8 assay and flow cytometry. The targeted binding of miR-524-5p with MCM3AP-AS1 or RBM39 was predicted by ECORI database and validated by dual-luciferase assays. The gain-and-loss of function assays were con...
Source: Molecular and Cellular Biochemistry - March 13, 2024 Category: Biochemistry Authors: Yueping Wang Xuedong Wang Haiyi Sun Ziyun Zhang Juan Gu Source Type: research

Walnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet type
Mol Cell Biochem. 2024 Mar 13. doi: 10.1007/s11010-024-04981-7. Online ahead of print.ABSTRACTDietary interventions that modulate the brown adipose tissue (BAT) thermogenic activity could represent a promising therapy for metabolic disorders. In order to examine if dietary walnuts intake regulates the expression of BAT thermogenic markers levels in healthy and metabolically challenged (fructose fed) animals, rats were initially divided into the control and fructose-fed groups. After nine weeks, these groups were subdivided into the one kept on the original regimens and the other supplemented with walnuts. High-fructose die...
Source: Molecular and Cellular Biochemistry - March 13, 2024 Category: Biochemistry Authors: Tamara Dakic Dusan Jeremic Iva Lakic Nebojsa Jasnic Aleksandra Ruzicic Predrag Vujovic Tanja Jevdjovic Source Type: research