Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hydrogen sulfide inhibits gene expression associated with aortic valve degeneration by inducing NRF2-related pro-autophagy effect in human aortic valve interstitial cells
In conclusion, H2S decreased gene expression levels related to aortic valve degeneration and activated AMPK-mTOR-mediated pro-autophagy function associated with NRF2 in human AVICs. Therefore, H2S could be a potential therapeutic target for the development of AS treatment.PMID:37861880 | DOI:10.1007/s11010-023-04881-2 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - October 20, 2023 Category: Biochemistry Authors: Naaleum Song Jeong Eun Yu Eunhye Ji Kyoung-Hee Choi Sahmin Lee Source Type: research

Discrete interplay of gut microbiota L-tryptophan metabolites in host biology and disease
Mol Cell Biochem. 2023 Oct 20. doi: 10.1007/s11010-023-04867-0. Online ahead of print.ABSTRACTThe gut microbiota and the host maintain a conjoint relationship and together achieve optimal physiology via a multitude of interactive signalling cues. Dietary-derived L-tryptophan (L-trp) is enzymatically metabolized by the resident symbiotic gut microbiota to indole and various indole derivatives. Indole and indole metabolites secreted by the gut bacteria act locally in the intestinal cells as well as distally and modulate tissue-specific functions which are beneficial to the host. Functions attributed to these microbial indole...
Source: Molecular and Cellular Biochemistry - October 20, 2023 Category: Biochemistry Authors: Harmit S Ranhotra Source Type: research

Novel functions of the ER-located Hsp40s DNAJB12 and DNAJB14 on proteins at the outer mitochondrial membrane under stress mediated by CCCP
This study elucidates a novel facet of JB12 and JB14 in that their expression could be regulated in response to stress caused by the presence of ER stressors and the mitochondrial potential uncoupler CCCP. Furthermore, JB14 overexpression could affect the level of PTEN-induced kinase 1 (PINK1) expression under CCCP-mediated stress. Cells with genetic knockout (KO) of DNAJB12 and DNAJB14 exhibited an altered kinetic of phosphorylated Drp1 in response to the stress caused by CCCP treatment. Surprisingly, JB14-KO cells exhibited a prolonged stabilization of PINK1 during chronic exposure to CCCP. Cells depleted with JB12 or JB...
Source: Molecular and Cellular Biochemistry - October 18, 2023 Category: Biochemistry Authors: Pattarawut Sopha Tirawit Meerod Bunkuea Chantrathonkul Nadgrita Phutubtim Douglas M Cyr Piyarat Govitrapong Source Type: research