Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling
In conclusion, our study demonstrated that TRIM3 exerts a tumor-suppressive effect in ovarian cancer, at least partially, by downregulating LDHA and inhibiting the AKT signaling pathway, and thus leading to the inhibition of glycolysis and limiting the growth of ovarian cancer cells.PMID:38367118 | DOI:10.1007/s11010-023-04920-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 17, 2024 Category: Biochemistry Authors: Yu Cong Xin Cui Yaqian Shi Xinxing Pan Ke Huang Zhe Geng Pengfei Xu Lili Ge Jin Zhu Juan Xu Xuemei Jia Source Type: research

Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling
In conclusion, our study demonstrated that TRIM3 exerts a tumor-suppressive effect in ovarian cancer, at least partially, by downregulating LDHA and inhibiting the AKT signaling pathway, and thus leading to the inhibition of glycolysis and limiting the growth of ovarian cancer cells.PMID:38367118 | DOI:10.1007/s11010-023-04920-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 17, 2024 Category: Biochemistry Authors: Yu Cong Xin Cui Yaqian Shi Xinxing Pan Ke Huang Zhe Geng Pengfei Xu Lili Ge Jin Zhu Juan Xu Xuemei Jia Source Type: research

Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated with H2O2 to induce oxidative injury. Cell viability was measured by Cell Counting Kit-8, and apoptosis was determined by flow cytometry and western blot assays. Reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels were examined to evaluate oxidative stress levels. In addition, Thioredoxin-1 (Trx1) was silenced in RGC-5 cells using small interfering RNA followed by signaling pathway examination to explo...
Source: Molecular and Cellular Biochemistry - February 14, 2024 Category: Biochemistry Authors: Shan Gao Qiaochu Cheng Yaguang Hu Xiaojuan Fan Chen Liang Chen Niu Qianyan Kang Ting Wei Source Type: research

Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated with H2O2 to induce oxidative injury. Cell viability was measured by Cell Counting Kit-8, and apoptosis was determined by flow cytometry and western blot assays. Reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels were examined to evaluate oxidative stress levels. In addition, Thioredoxin-1 (Trx1) was silenced in RGC-5 cells using small interfering RNA followed by signaling pathway examination to explo...
Source: Molecular and Cellular Biochemistry - February 14, 2024 Category: Biochemistry Authors: Shan Gao Qiaochu Cheng Yaguang Hu Xiaojuan Fan Chen Liang Chen Niu Qianyan Kang Ting Wei Source Type: research

Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated with H2O2 to induce oxidative injury. Cell viability was measured by Cell Counting Kit-8, and apoptosis was determined by flow cytometry and western blot assays. Reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels were examined to evaluate oxidative stress levels. In addition, Thioredoxin-1 (Trx1) was silenced in RGC-5 cells using small interfering RNA followed by signaling pathway examination to explo...
Source: Molecular and Cellular Biochemistry - February 14, 2024 Category: Biochemistry Authors: Shan Gao Qiaochu Cheng Yaguang Hu Xiaojuan Fan Chen Liang Chen Niu Qianyan Kang Ting Wei Source Type: research

Exosomes released by oxidative stress-induced mesenchymal stem cells promote murine mammary tumor progression through activating the STAT3 signaling pathway
Mol Cell Biochem. 2024 Feb 13. doi: 10.1007/s11010-024-04934-0. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) may play a pivotal role in shaping the tumor microenvironment (TME), influencing tumor growth. Nonetheless, conflicting evidence exists regarding the distinct impacts of MSCs on tumor progression, with some studies suggesting promotion while others indicate suppression of tumor cell growth. Considering that oxidative stress is implicated in the dynamic interaction between components of the TME and tumor cells, we investigated the contribution of exosomes released by hydrogen peroxide (H2O2)-treated MS...
Source: Molecular and Cellular Biochemistry - February 13, 2024 Category: Biochemistry Authors: Mansour Almouh Katayoon Pakravan Mohammad H Ghazimoradi Romina Motamed Babak Bakhshinejad Zuhair Mohammad Hassan Sadegh Babashah Source Type: research

P4HA3 promotes colon cancer cell escape from macrophage phagocytosis by increasing phagocytosis immune checkpoint CD47 expression
Mol Cell Biochem. 2024 Feb 12. doi: 10.1007/s11010-024-04927-z. Online ahead of print.ABSTRACTCancer immunotherapies have greatly changed the prospects for the therapy of many malignancies, including colon cancer. Macrophages as the effectors of cancer immunotherapy provide considerable promise for cancer treatment. Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) plays a cancer-promoting role in a variety of cancers, including colon cancer. In the present work, we provided evidence for the first time that P4HA3 promoted colon cancer cell escape from macrophage phagocytosis, and preliminarily explored its possible molecular me...
Source: Molecular and Cellular Biochemistry - February 12, 2024 Category: Biochemistry Authors: Hailang Zhou Junwei Zou Jingli Han Aijun Zhou Shu Huang Source Type: research

WDR12/RAC1 axis promoted proliferation and anti-apoptosis in colorectal cancer cells
CONCLUSION: Our study demonstrates that the WDR12/RAC1 axis promotes tumor progression in CRC. Therefore, WDR12 may serve as a novel oncogene and a potential target for individualized therapy in CRC. These findings provide an experimental foundation for the clinical development of drugs targeting the WDR12/RAC1 axis.PMID:38341833 | DOI:10.1007/s11010-024-04937-x (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 11, 2024 Category: Biochemistry Authors: Su Wen Xueqing Huang Liping Xiong Hao Zeng Shuang Wu Kangli An Jing Bai Zhipeng Zhou Tiejun Yin Source Type: research

Functional activity and morphology of isolated rat cardiac mitochondria under calcium overload. Effect of naringin
Mol Cell Biochem. 2024 Feb 8. doi: 10.1007/s11010-024-04935-z. Online ahead of print.ABSTRACTThe function of mitochondria as a regulator of myocyte calcium homeostasis has been extensively discussed. The aim of the present work was further clarification of the details of modulation of the functional activity of rat cardiac mitochondria by exogenous Ca2+ ions either in the absence or in the presence of the plant flavonoid naringin. Low free Ca2+ concentrations (40-250 nM) effectively inhibited the respiratory activity of heart mitochondria, remaining unaffected the efficacy of oxygen consumption. In the presence of high exo...
Source: Molecular and Cellular Biochemistry - February 9, 2024 Category: Biochemistry Authors: T A Kavalenia E A Lapshina T V Ilyich Hu-Cheng Zhao I B Zavodnik Source Type: research

Retraction Note: Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/ β-catenin pathway
Mol Cell Biochem. 2024 Feb 8. doi: 10.1007/s11010-024-04959-5. Online ahead of print.NO ABSTRACTPMID:38329637 | DOI:10.1007/s11010-024-04959-5 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 8, 2024 Category: Biochemistry Authors: Yanyan Cui Luyu Zhang Wenjie Wang Shanshan Ma Hongtao Liu Xingxing Zang Yanting Zhang Fangxia Guan Source Type: research

ER stress improvement by aerobic training or enalapril differently ameliorates pathological cardiac remodeling in obese mice
Mol Cell Biochem. 2024 Feb 3. doi: 10.1007/s11010-024-04925-1. Online ahead of print.ABSTRACTOveractivation of the classic arm of the renin-angiotensin system (RAS) is one of the main mechanisms involved in obesity-related cardiac remodeling, and a possible relationship between RAS and ER stress in the cardiovascular system have been described. Thus, the aim of this study is to evaluate if activating the protective arm of the RAS by ACE inhibition or aerobic exercise training could overturn diet-induced pathological cardiac hypertrophy by attenuating ER stress. Male C57BL/6 mice were fed a control (SC) or a high-fat diet (...
Source: Molecular and Cellular Biochemistry - February 3, 2024 Category: Biochemistry Authors: Amanda Concei ção Pimenta Salles Beatriz Alexandre-Santos Thais de Souza Carvalho Ana Beatriz Proen ça Vinicius Sep úlveda-Fragoso Tiago Fernandes Edilamar Menezes Oliveira Antonio Claudio Lucas da N óbrega Eliete Dalla Corte Frantz D'Angelo Carlo Ma Source Type: research

The frequency of the ACE I/D polymorphism in South America: a systematic review and meta-analysis
This study aimed to verify the allelic predominance and genotype frequency of ACE I/D polymorphism in South America and its association with the main diseases and related conditions. We conducted a systematic review considering studies published in the last 25 years available in PubMed, Scielo, LILACS, LIPECS, Coleciona SUS, CUMED, BINACIS, IBECS, and MEDLINE databases, resulting in the inclusion of 121 studies. Quality of the studies was assessed according to the Strengthening the Reporting of Genetic Association (STREGA) guidelines. We mapped the frequency of the ACE I/D polymorphism in South American populations. 8,856 ...
Source: Molecular and Cellular Biochemistry - February 3, 2024 Category: Biochemistry Authors: Rebeca Gon çalves Trevisano Helen Matias Thais de Jesus Teani Valmir Oliveira Silvino Cirley Pinheiro Ferreira Marcos Antonio Pereira Dos Santos Pedro Luiz Garcia Braga Sandro Soares Almeida Source Type: research

ALKBH5 facilitates the progression of infantile hemangioma by increasing FOXF1 expression in a m < sup > 6 < /sup > A-YTHDF2 dependent manner to activate HK-2 signaling
Mol Cell Biochem. 2024 Feb 2. doi: 10.1007/s11010-024-04936-y. Online ahead of print.ABSTRACTAlkylation repair homolog protein 5 (ALKBH5) is reported to participate in infantile hemangioma (IH) progression. However, the underlying mechanism of ALKBH5 in IH remains unclear. Using qRT-PCR and Western blotting, ALKBH5, forkhead box F1 (FOXF1) and hexokinase 2 (HK-2) expressions in IH tissues and IH-derived endothelial cells XPTS-1 were assessed. The Me-RIP assay was used to analyze FOXF1 m6A level. CCK8, colony formation, flow cytometry and transwell assays were employed to determine IH cell viability, proliferation, apoptosi...
Source: Molecular and Cellular Biochemistry - February 2, 2024 Category: Biochemistry Authors: Kun Peng Ren-Peng Xia Fan Zhao Yong Xiao Ti-Dong Ma Ming Li Yong Feng Chong-Gao Zhou Source Type: research

Non-coding RNAs and angiogenesis in cardiovascular diseases: a comprehensive review
Mol Cell Biochem. 2024 Feb 2. doi: 10.1007/s11010-023-04919-5. Online ahead of print.ABSTRACTNon-coding RNAs (ncRNAs) have key roles in the etiology of many illnesses, including heart failure, myocardial infarction, stroke, and in physiological processes like angiogenesis. In transcriptional regulatory circuits that control heart growth, signaling, and stress response, as well as remodeling in cardiac disease, ncRNAs have become important players. Studies on ncRNAs and cardiovascular disease have made great progress recently. Here, we go through the functions of non-coding RNAs (ncRNAs) like circular RNAs (circRNAs), and m...
Source: Molecular and Cellular Biochemistry - February 2, 2024 Category: Biochemistry Authors: Jie Zhang Source Type: research

TRPM2 knockdown attenuates myocardial apoptosis and promotes autophagy in HFD/STZ-induced diabetic mice via regulating the MEK/ERK and mTORC1 signaling pathway
Mol Cell Biochem. 2024 Feb 3. doi: 10.1007/s11010-024-04926-0. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a major complication of diabetes. Transient receptor potential melastatin 2 (TRPM2) activity increases in diabetic oxidative stress state, and it is involved in myocardial damage and repair. We explore the protective effect of TRPM2 knockdown on the progression of DCM. A type 2 diabetes animal model was established in C57BL/6N mice by long-term high-fat diet (HFD) feeding combined with a single injection of 100-mg/kg streptozotocin (STZ). Genetic knockdown of TRPM2 in heart was accomplished by the i...
Source: Molecular and Cellular Biochemistry - February 2, 2024 Category: Biochemistry Authors: Feng Hu Chaoyang Lin Source Type: research