Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy
Mol Cell Biochem. 2024 Jan 8. doi: 10.1007/s11010-023-04909-7. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) represents a distinct myocardial disorder elicited by diabetes mellitus, characterized by aberrations in myocardial function and structural integrity. This pathological condition predominantly manifests in individuals with diabetes who do not have concurrent coronary artery disease or hypertension. An escalating body of scientific evidence substantiates the pivotal role of programmed cell death (PCD)-encompassing apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis-in the pathogenic progressi...
Source: Molecular and Cellular Biochemistry - January 8, 2024 Category: Biochemistry Authors: Bingrui Zhang Hua Wu Jingwen Zhang Cong Cong Lin Zhang Source Type: research

N6-methyladenosine-induced miR-182-5p promotes multiple myeloma tumorigenesis by regulating CAMK2N1
Mol Cell Biochem. 2024 Jan 5. doi: 10.1007/s11010-023-04906-w. Online ahead of print.ABSTRACTMethyltransferase like 3 (METTL3) has been reported to promote tumorigenesis of multiple myeloma (MM), however, the molecular mechanism still needs further research. The N6-methyladenosine (m6A) level in tissues or cells was measured by m6A kit and dot blot assay. The mRNA and protein expression were detected by quantitative real-time PCR (RT-qPCR) and Western blot, respectively. The cell counting kit-8 and colony formation assay were used to detect the cell proliferation. Coimmunoprecipitation (Co-IP) experiment verified the bindi...
Source: Molecular and Cellular Biochemistry - January 5, 2024 Category: Biochemistry Authors: Jing Bao Tingting Xu Wanjie Wang Han Xu Xiaowen Chen Ruixiang Xia Source Type: research

Hypoxia-induced SHMT2 protein lactylation facilitates glycolysis and stemness of esophageal cancer cells
Mol Cell Biochem. 2024 Jan 4. doi: 10.1007/s11010-023-04913-x. Online ahead of print.ABSTRACTEsophageal cancer (EC) is a familiar digestive tract tumor with highly lethal. The hypoxic environment has been demonstrated to be a significant factor in modulating malignant tumor progression and is strongly associated with the abnormal energy metabolism of tumor cells. Serine hydroxymethyl transferase 2 (SHMT2) is one of the most frequently expressed metabolic enzymes in human malignancies. The study was designed to investigate the biological functions and regulation mechanisms of SHMT2 in EC under hypoxia. We conducted RT-qPCR ...
Source: Molecular and Cellular Biochemistry - January 4, 2024 Category: Biochemistry Authors: Zhe Qiao Yu Li Shaomin Li Shiyuan Liu Yao Cheng Source Type: research

Drugs targeting TGF- β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion
Mol Cell Biochem. 2023 Dec 29. doi: 10.1007/s11010-023-04912-y. Online ahead of print.ABSTRACTHypertrophic scar (HS) formation is a cutaneous fibroproliferative disease that occurs after skin injuries and results in severe functional and esthetic disability. To date, few drugs have shown satisfactory outcomes for the treatment of HS formation. Transforming growth factor-beta (TGF-β)/Notch interaction via small mothers against decapentaplegic 3 (Smad3) could facilitate HS formation; therefore, targeting TGF-β/ Notch interaction via Smad3 is a potential therapeutic strategy to attenuate HS formation. In addition, optic atr...
Source: Molecular and Cellular Biochemistry - December 29, 2023 Category: Biochemistry Authors: Da Huo Xin-Yu Bi Jun-Ling Zeng Da-Mao Dai Xiang-Lin Dong Source Type: research

Relevance and mechanism of STAT3/miR-221-3p/Fascin-1 axis in EGFR TKI resistance of triple-negative breast cancer
Mol Cell Biochem. 2023 Dec 25. doi: 10.1007/s11010-023-04907-9. Online ahead of print.ABSTRACTThe epidermal growth factor receptor 1 (EGFR) plays a crucial role in the progression of various malignant tumors and is considered a potential target for treating triple-negative breast cancer (TNBC). However, the effectiveness of representative tyrosine kinase inhibitors (TKIs) used in EGFR-targeted therapy is limited in TNBC patients. In our study, we observed that the TNBC cell lines MDA-MB-231 and MDA-MB-468 exhibited resistance to Gefitinib. Treatment with Gefitinib caused an upregulation of Fascin-1 (FSCN1) protein expressi...
Source: Molecular and Cellular Biochemistry - December 25, 2023 Category: Biochemistry Authors: Lu-Lu Jin Hua-Jun Lu Jun-Kang Shao Yan Wang Shi-Ping Lu Bi-Fei Huang Gui-Nv Hu Hong-Chuan Jin Chao-Qun Wang Source Type: research

HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress
Mol Cell Biochem. 2023 Dec 25. doi: 10.1007/s11010-023-04902-0. Online ahead of print.ABSTRACTPhenotypic change of vascular smooth muscle cells (VSMCs) is the main contributor of vascular pathological remodeling in atherosclerosis. The endoplasmic reticulum (ER) is critical for maintaining VSMC function through elimination of misfolded proteins that impair VSMC cellular function. ER-associated degradation (ERAD) is an ER-mediated process that controls protein quality by clearing misfolded proteins. One of the critical regulators of ERAD is HRD1, which also plays a vital role in lipid metabolism. However, the function of HR...
Source: Molecular and Cellular Biochemistry - December 25, 2023 Category: Biochemistry Authors: Linli Wang Zhitao Ren Lin Wu Ximei Zhang Min Wang Haiming Niu Xuemin He Heting Wang Yanming Chen Guojun Shi Xiaoxian Qian Source Type: research