Molecular and Cellular Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

CircHAT1 regulates the proliferation and phenotype switch of vascular smooth muscle cells in lower extremity arteriosclerosis obliterans through targeting SFRS1
This study aimed to decipher the mechanism of circular ribonucleic acids (circRNAs) in lower extremity arteriosclerosis obliterans (LEASO). First, bioinformatics analysis was performed for screening significantly down-regulated cardiac specific circRNA-circHAT1 in LEASO. The expression of circHAT1 in LEASO clinical samples was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression of splicing factor arginine/serine-rich 1 (SFRS1), α-smooth muscle actin (α-SMA), Calponin (CNN1), cyclin D1 (CNND1) and smooth muscle myosin heavy chain 11 (SMHC) in vascular smooth muscle cells (VSMCs) ...
Source: Molecular and Cellular Biochemistry - February 27, 2024 Category: Biochemistry Authors: Xian-Ying Huang Fang-Yong Fu Kai Qian Qiao-Li Feng Sai Cao Wei-Yu Wu Yuan-Lin Luo Wei-Jie Chen Zhi Zhang Shui-Chuan Huang Source Type: research

KIF4A promotes epithelial-mesenchymal transition by activating the TGF- β/SMAD signaling pathway in glioma cells
Mol Cell Biochem. 2024 Feb 27. doi: 10.1007/s11010-024-04943-z. Online ahead of print.ABSTRACTGliomas are the most prevalent type of primary brain tumor, with poor prognosis reported in patients with high-grade glioma. Kinesin family member 4 A (KIF4A) stimulates the proliferation, migration, and invasion of tumor cells. However, its function in gliomas has not been clearly established. Therefore, this study aimed to investigate the effects of KIF4A on the epithelial-mesenchymal transition and invasion of glioma cells. We searched The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases to identify KIF4A-related s...
Source: Molecular and Cellular Biochemistry - February 27, 2024 Category: Biochemistry Authors: Yao Xu Guangren Xue Lei Zhou Gaotian Wu Lingji Hu Shuchen Ma Jian Zhang Xiangdong Li Source Type: research

Retraction Note: The levels of pro- and anti-inflammatory cytokines in premature infants with perinatal infections
Mol Cell Biochem. 2024 Feb 27. doi: 10.1007/s11010-024-04972-8. Online ahead of print.NO ABSTRACTPMID:38411897 | DOI:10.1007/s11010-024-04972-8 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 27, 2024 Category: Biochemistry Authors: Akmaral K Zhumalina Balash T Tusupkaliev Mairamkul B Zharlykasinova Botagoz A Zhekeyeva Klara B Darzhanova Source Type: research

Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy
Mol Cell Biochem. 2024 Feb 28. doi: 10.1007/s11010-024-04933-1. Online ahead of print.ABSTRACTCancer remains a major global health concern with high mortality rates mainly due to late diagnosis and poor prognosis. Long non-coding RNAs (lncRNAs) are emerging as key regulators of gene expression in human cancer, functioning through various mechanisms including as competing endogenous RNAs (ceRNAs) and indirectly regulating miRNA expression. LncRNAs have been found to have both oncogenic and tumor-suppressive roles in cancer, with the former promoting cancer cell proliferation, migration, invasion, and poor prognosis. Recent ...
Source: Molecular and Cellular Biochemistry - February 27, 2024 Category: Biochemistry Authors: Lokesh K Kadian Deepika Verma Neelam Lohani Ritu Yadav Shalu Ranga Gulshan Gulshan Sanghapriya Pal Kiran Kumari Shyam S Chauhan Source Type: research

Retraction Note: MEK/ERK pathway activation by insulin receptor isoform alteration is associated with the abnormal proliferation and differentiation of intestinal epithelial cells in diabetic mice
Mol Cell Biochem. 2024 Feb 26. doi: 10.1007/s11010-024-04969-3. Online ahead of print.NO ABSTRACTPMID:38407731 | DOI:10.1007/s11010-024-04969-3 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 26, 2024 Category: Biochemistry Authors: Hui Ouyang Hong-Sheng Yang Tao Yu Ti-Dong Shan Jie-Yao Li Can-Ze Huang Wa Zhong Zhong-Sheng Xia Qi-Kui Chen Source Type: research

Retraction Note: Lidocaine alleviates cytotoxicity-resistance in lung cancer A549/DDP cells via down-regulation of miR-21
Mol Cell Biochem. 2024 Feb 26. doi: 10.1007/s11010-024-04971-9. Online ahead of print.NO ABSTRACTPMID:38407732 | DOI:10.1007/s11010-024-04971-9 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 26, 2024 Category: Biochemistry Authors: Qing Yang Zhi Zhang Haixia Xu Chuangen Ma Source Type: research

Neutrophil extracellular traps: a catalyst for atherosclerosis
Mol Cell Biochem. 2024 Feb 24. doi: 10.1007/s11010-024-04931-3. Online ahead of print.ABSTRACTNeutrophil extracellular traps (NETs) are network-like structures released by activated neutrophils. They consist mainly of double-stranded DNA, histones, and neutrophil granule proteins. Continuous release of NETs in response to external stimuli leads to activation of surrounding platelets and monocytes/macrophages, resulting in damage to endothelial cells (EC) and vascular smooth muscle cells (VSMC). Some clinical trials have demonstrated the association between NETs and the severity and prognosis of atherosclerosis. Furthermore...
Source: Molecular and Cellular Biochemistry - February 24, 2024 Category: Biochemistry Authors: Yinyu Wang Cuiping Wang Jiayan Li Source Type: research

MYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1
This study explored the role of miR-7-5p in the progression of DLBCL and pursued the underlying mechanism. Quantitative real-time PCR and transfection of miRNA mimic and inhibitors were used to assess the effects of miR-7-5p on autophagy and apoptosis in SU-DHL-4 and SU-DHL-10 cells. Dual-luciferase reporter assay was used to identify target genes of miR-7-5p. Immunofluorescence, flow cytometry, and western blotting (WB) were performed to explore the underlying mechanism and downstream pathways of miR-7-5p and AMBRA1 in DLBCL cells. MiR-7-5p was upregulated in DLBCL cells. Luciferase reporter assays implicated AMBRA1 as a ...
Source: Molecular and Cellular Biochemistry - February 23, 2024 Category: Biochemistry Authors: Cuifen Zhang Ke Wang Jiahao Tao Chuangjie Zheng Linzhu Zhai Source Type: research

METTL3-mediated m6A modification of NORAD inhibits the ferroptosis of vascular smooth muscle cells to attenuate the aortic dissection progression in an YTHDF2-dependent manner
In conclusion, METTL3-mediated NORAD inhibited ferroptosis of VSMCs via the HUR/GPX4 axis and decelerated AAD progression, suggesting that NORAD may be an AD therapeutic target.PMID:38383916 | DOI:10.1007/s11010-024-04930-4 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 22, 2024 Category: Biochemistry Authors: Mingfang Liao Sili Zou Jianjin Wu Jun Bai Yandong Liu Kangkang Zhi Lefeng Qu Source Type: research

Role of AMP deaminase in diabetic cardiomyopathy
Mol Cell Biochem. 2024 Feb 22. doi: 10.1007/s11010-024-04951-z. Online ahead of print.ABSTRACTDiabetes mellitus is one of the major causes of ischemic and nonischemic heart failure. While hypertension and coronary artery disease are frequent comorbidities in patients with diabetes, cardiac contractile dysfunction and remodeling occur in diabetic patients even without comorbidities, which is referred to as diabetic cardiomyopathy. Investigations in recent decades have demonstrated that the production of reactive oxygen species (ROS), impaired handling of intracellular Ca2+, and alterations in energy metabolism are involved ...
Source: Molecular and Cellular Biochemistry - February 22, 2024 Category: Biochemistry Authors: Tetsuji Miura Hidemichi Kouzu Masaya Tanno Yuki Tatekoshi Atsushi Kuno Source Type: research