Molecular and Cellular Biochemistry 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Identification of key genes of diabetic cardiomyopathy in hiPSCs-CMs based on bioinformatics analysis
In this study, bioinformatics analysis was used to predict DbCM-related gene targets. Published datasets from the NCBI Gene Expression Omnibus with accession numbers GSE62203 and GSE197850 were selected for analysis. Differentially expressed genes (DEGs) were identified by the online tool GEO2R. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the DAVID online database. Protein-protein interaction network construction and hub gene identification were performed using STRING and Cytoscape. We used 30 mM and 1 μM hydrocortisone-stimulated AC16 cells as an ...
Source: Molecular and Cellular Biochemistry - February 21, 2024 Category: Biochemistry Authors: Shuo An Hongchen Bi Xiaoli Luo Caiying Zhu Min Wang Aiming Pang Yujie Cui Source Type: research
Circ_0004872 deficiency attenuates ox-LDL-induced vascular smooth muscle cell dysfunction by miR-424-5p-dependent regulation of FRS2
Mol Cell Biochem. 2024 Feb 20. doi: 10.1007/s11010-024-04929-x. Online ahead of print.ABSTRACTAtherosclerosis (AS) is a pivotal pathological basis of cardiovascular and cerebrovascular diseases, and circular RNAs (circRNAs) has been disclosed to exert a vital part in the progression of AS. However, the functions of circ_0004872 in the progression of AS is indistinct. In this context, we aimed to elucidate the role of circ_0004872 and the potential mechanism in AS. The level of circ_0004872, miR-424-5p and fibroblast growth factor receptor substrate 2 (FRS2) was detected using quantitative real-time polymerase chain reactio...
Source: Molecular and Cellular Biochemistry - February 20, 2024 Category: Biochemistry Authors: Peng Qian Xuanchao Cao Qian Zhang Meihua Gao Xin Liu Lijie Yan Source Type: research
Retraction Note: Tactics for treating young children with pyelonephritis and vesicoureteral reflux associated with impaired fibrillogenesis
Mol Cell Biochem. 2024 Feb 20. doi: 10.1007/s11010-024-04963-9. Online ahead of print.NO ABSTRACTPMID:38376664 | DOI:10.1007/s11010-024-04963-9 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 20, 2024 Category: Biochemistry Authors: Nataliia Lukyanenko Evelina Lenha Anastasiya Spaska Tetiana Klets Tetiana Shevchenko Source Type: research
Circ_0004872 deficiency attenuates ox-LDL-induced vascular smooth muscle cell dysfunction by miR-424-5p-dependent regulation of FRS2
Mol Cell Biochem. 2024 Feb 20. doi: 10.1007/s11010-024-04929-x. Online ahead of print.ABSTRACTAtherosclerosis (AS) is a pivotal pathological basis of cardiovascular and cerebrovascular diseases, and circular RNAs (circRNAs) has been disclosed to exert a vital part in the progression of AS. However, the functions of circ_0004872 in the progression of AS is indistinct. In this context, we aimed to elucidate the role of circ_0004872 and the potential mechanism in AS. The level of circ_0004872, miR-424-5p and fibroblast growth factor receptor substrate 2 (FRS2) was detected using quantitative real-time polymerase chain reactio...
Source: Molecular and Cellular Biochemistry - February 20, 2024 Category: Biochemistry Authors: Peng Qian Xuanchao Cao Qian Zhang Meihua Gao Xin Liu Lijie Yan Source Type: research
Retraction Note: Tactics for treating young children with pyelonephritis and vesicoureteral reflux associated with impaired fibrillogenesis
Mol Cell Biochem. 2024 Feb 20. doi: 10.1007/s11010-024-04963-9. Online ahead of print.NO ABSTRACTPMID:38376664 | DOI:10.1007/s11010-024-04963-9 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 20, 2024 Category: Biochemistry Authors: Nataliia Lukyanenko Evelina Lenha Anastasiya Spaska Tetiana Klets Tetiana Shevchenko Source Type: research
Molecular mechanisms of ferroptosis in cardiovascular disease
Mol Cell Biochem. 2024 Feb 19. doi: 10.1007/s11010-024-04940-2. Online ahead of print.ABSTRACTFerroptosis is a newly recognized type of regulated cell death that is characterized by the accumulation of iron and lipid peroxides in cells. Studies have shown that ferroptosis plays a significant role in the pathogenesis of various diseases, including cardiovascular diseases. In cardiovascular disease, ferroptosis is associated with ischemia-reperfusion injury, myocardial infarction, heart failure, and atherosclerosis. The molecular mechanisms underlying ferroptosis include the iron-dependent accumulation of lipid peroxidation ...
Source: Molecular and Cellular Biochemistry - February 19, 2024 Category: Biochemistry Authors: Qun Zeng Tingting Jiang Source Type: research
Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling
In conclusion, our study demonstrated that TRIM3 exerts a tumor-suppressive effect in ovarian cancer, at least partially, by downregulating LDHA and inhibiting the AKT signaling pathway, and thus leading to the inhibition of glycolysis and limiting the growth of ovarian cancer cells.PMID:38367118 | DOI:10.1007/s11010-023-04920-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 17, 2024 Category: Biochemistry Authors: Yu Cong Xin Cui Yaqian Shi Xinxing Pan Ke Huang Zhe Geng Pengfei Xu Lili Ge Jin Zhu Juan Xu Xuemei Jia Source Type: research
Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling
In conclusion, our study demonstrated that TRIM3 exerts a tumor-suppressive effect in ovarian cancer, at least partially, by downregulating LDHA and inhibiting the AKT signaling pathway, and thus leading to the inhibition of glycolysis and limiting the growth of ovarian cancer cells.PMID:38367118 | DOI:10.1007/s11010-023-04920-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 17, 2024 Category: Biochemistry Authors: Yu Cong Xin Cui Yaqian Shi Xinxing Pan Ke Huang Zhe Geng Pengfei Xu Lili Ge Jin Zhu Juan Xu Xuemei Jia Source Type: research
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated with H2O2 to induce oxidative injury. Cell viability was measured by Cell Counting Kit-8, and apoptosis was determined by flow cytometry and western blot assays. Reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels were examined to evaluate oxidative stress levels. In addition, Thioredoxin-1 (Trx1) was silenced in RGC-5 cells using small interfering RNA followed by signaling pathway examination to explo...
Source: Molecular and Cellular Biochemistry - February 14, 2024 Category: Biochemistry Authors: Shan Gao Qiaochu Cheng Yaguang Hu Xiaojuan Fan Chen Liang Chen Niu Qianyan Kang Ting Wei Source Type: research
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated with H2O2 to induce oxidative injury. Cell viability was measured by Cell Counting Kit-8, and apoptosis was determined by flow cytometry and western blot assays. Reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels were examined to evaluate oxidative stress levels. In addition, Thioredoxin-1 (Trx1) was silenced in RGC-5 cells using small interfering RNA followed by signaling pathway examination to explo...
Source: Molecular and Cellular Biochemistry - February 14, 2024 Category: Biochemistry Authors: Shan Gao Qiaochu Cheng Yaguang Hu Xiaojuan Fan Chen Liang Chen Niu Qianyan Kang Ting Wei Source Type: research
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated with H2O2 to induce oxidative injury. Cell viability was measured by Cell Counting Kit-8, and apoptosis was determined by flow cytometry and western blot assays. Reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels were examined to evaluate oxidative stress levels. In addition, Thioredoxin-1 (Trx1) was silenced in RGC-5 cells using small interfering RNA followed by signaling pathway examination to explo...
Source: Molecular and Cellular Biochemistry - February 14, 2024 Category: Biochemistry Authors: Shan Gao Qiaochu Cheng Yaguang Hu Xiaojuan Fan Chen Liang Chen Niu Qianyan Kang Ting Wei Source Type: research
Exosomes released by oxidative stress-induced mesenchymal stem cells promote murine mammary tumor progression through activating the STAT3 signaling pathway
Mol Cell Biochem. 2024 Feb 13. doi: 10.1007/s11010-024-04934-0. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) may play a pivotal role in shaping the tumor microenvironment (TME), influencing tumor growth. Nonetheless, conflicting evidence exists regarding the distinct impacts of MSCs on tumor progression, with some studies suggesting promotion while others indicate suppression of tumor cell growth. Considering that oxidative stress is implicated in the dynamic interaction between components of the TME and tumor cells, we investigated the contribution of exosomes released by hydrogen peroxide (H2O2)-treated MS...
Source: Molecular and Cellular Biochemistry - February 13, 2024 Category: Biochemistry Authors: Mansour Almouh Katayoon Pakravan Mohammad H Ghazimoradi Romina Motamed Babak Bakhshinejad Zuhair Mohammad Hassan Sadegh Babashah Source Type: research
P4HA3 promotes colon cancer cell escape from macrophage phagocytosis by increasing phagocytosis immune checkpoint CD47 expression
Mol Cell Biochem. 2024 Feb 12. doi: 10.1007/s11010-024-04927-z. Online ahead of print.ABSTRACTCancer immunotherapies have greatly changed the prospects for the therapy of many malignancies, including colon cancer. Macrophages as the effectors of cancer immunotherapy provide considerable promise for cancer treatment. Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) plays a cancer-promoting role in a variety of cancers, including colon cancer. In the present work, we provided evidence for the first time that P4HA3 promoted colon cancer cell escape from macrophage phagocytosis, and preliminarily explored its possible molecular me...
Source: Molecular and Cellular Biochemistry - February 12, 2024 Category: Biochemistry Authors: Hailang Zhou Junwei Zou Jingli Han Aijun Zhou Shu Huang Source Type: research
WDR12/RAC1 axis promoted proliferation and anti-apoptosis in colorectal cancer cells
CONCLUSION: Our study demonstrates that the WDR12/RAC1 axis promotes tumor progression in CRC. Therefore, WDR12 may serve as a novel oncogene and a potential target for individualized therapy in CRC. These findings provide an experimental foundation for the clinical development of drugs targeting the WDR12/RAC1 axis.PMID:38341833 | DOI:10.1007/s11010-024-04937-x (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - February 11, 2024 Category: Biochemistry Authors: Su Wen Xueqing Huang Liping Xiong Hao Zeng Shuang Wu Kangli An Jing Bai Zhipeng Zhou Tiejun Yin Source Type: research
Functional activity and morphology of isolated rat cardiac mitochondria under calcium overload. Effect of naringin
Mol Cell Biochem. 2024 Feb 8. doi: 10.1007/s11010-024-04935-z. Online ahead of print.ABSTRACTThe function of mitochondria as a regulator of myocyte calcium homeostasis has been extensively discussed. The aim of the present work was further clarification of the details of modulation of the functional activity of rat cardiac mitochondria by exogenous Ca2+ ions either in the absence or in the presence of the plant flavonoid naringin. Low free Ca2+ concentrations (40-250 nM) effectively inhibited the respiratory activity of heart mitochondria, remaining unaffected the efficacy of oxygen consumption. In the presence of high exo...
Source: Molecular and Cellular Biochemistry - February 9, 2024 Category: Biochemistry Authors: T A Kavalenia E A Lapshina T V Ilyich Hu-Cheng Zhao I B Zavodnik Source Type: research
