Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling

In conclusion, our study demonstrated that TRIM3 exerts a tumor-suppressive effect in ovarian cancer, at least partially, by downregulating LDHA and inhibiting the AKT signaling pathway, and thus leading to the inhibition of glycolysis and limiting the growth of ovarian cancer cells.PMID:38367118 | DOI:10.1007/s11010-023-04920-y

Source: Molecular and Cellular Biochemistry - February 17, 2024 Category: Biochemistry Authors: Yu Cong Xin Cui Yaqian Shi Xinxing Pan Ke Huang Zhe Geng Pengfei Xu Lili Ge Jin Zhu Juan Xu Xuemei Jia Source Type: research