A common Matrix metalloproteinase 8 promoter haplotype enhances the risk for hypertension via diminished interactions with nuclear factor kappa B
Conclusion:
MMP8 promoter GTTT haplotype has a functional role in reducing MMP8 expression during inflammation via diminished interaction with NF-κB and in enhancing the risk of hypertension. (Source: Journal of Hypertension)
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Thermoneutrality induces vascular dysfunction and impaired metabolic function in male Wistar rats: a new model of vascular disease
Objective:
Cardiovascular disease is of paramount importance, yet there are few relevant rat models to investigate its pathology and explore potential therapeutics. Housing at thermoneutral temperature (30 °C) is being employed to humanize metabolic derangements in rodents. We hypothesized that housing rats in thermoneutral conditions would potentiate a high-fat diet, resulting in diabetes and dysmetabolism, and deleteriously impact vascular function, in comparison to traditional room temperature housing (22 °C).
Methods:
Male Wistar rats were housed at either room temperature or thermoneutral temperatures...
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Reduction of salt intake: time for more action
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: EDITORIAL Source Type: research
Management of intradialytic hypertension: current evidence and future perspectives
Intradialytic hypertension (IDH), that is, a paradoxical rise in blood pressure (BP) during or immediately after a hemodialysis session, affects approximately 10–15% of the hemodialysis population. It is currently recognized as a phenomenon of major clinical significance as recent studies have shown that BP elevation extends to the whole interdialytic interval and associates with increased cardiovascular and all-cause mortality. The pathophysiology of IDH is complex involving volume and sodium overload, endothelial dysfunction, excess renin–angiotensin–aldosterone system and sympathetic nervous system activation, and...
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: REVIEWS Source Type: research
The janus face of ketone bodies in hypertension
Hypertension is the most important risk factor for the development of terminal cardiovascular diseases, such as heart failure, chronic kidney disease, and atherosclerosis. Lifestyle interventions to lower blood pressure are generally desirable prior to initiating pharmaceutical drug treatments, which may have undesirable side effects. Ketogenic interventions are popular but the scientific literature supporting their efficacy is specific to certain interventions and outcomes in animal models and patient populations. For example, although caloric restriction has its own inherent difficulties (e.g. it requires high levels of ...
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: REVIEWS Source Type: research
Occupational risk factors for hypertension
The identification and characterization of the modifiable risk factors of hypertension is of great value for public health and clinical medicine to achieve primary prevention. A large amount of literature on the effects of occupational factors on blood pressure and hypertension has been published. In this review, I summarize current evidence regarding the role of occupational factors in hypertension. The results of this review suggest that there is sufficient evidence to support the association between increased risk of hypertension and job stress, shift work, occupational lead exposure, and noise exposure. The association...
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: REVIEWS Source Type: research
Diagnosis and management of hypertension in patients with Cushing's syndrome: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension
Endogenous/exogenous Cushing's syndrome is characterized by a cluster of systemic manifestations of hypercortisolism, which cause increased cardiovascular risk. Its biological basis is glucocorticoid excess, acting on various pathogenic processes inducing cardiovascular damage. Hypertension is a common feature in Cushing's syndrome and may persist after normalizing hormone excess and discontinuing steroid therapy. In endogenous Cushing's syndrome, the earlier the diagnosis the sooner management can be employed to offset the deleterious effects of excess cortisol. Such management includes combined treatments directed agains...
Source: Journal of Hypertension - October 18, 2022 Category: Cardiology Tags: CONSENSUS DOCUMENT Source Type: research
Distinct transcriptomic profile of small arteries of hypertensive patients with chronic kidney disease identified miR-338-3p targeting GPX3 and PTPRS: Erratum
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: ERRATUM Source Type: research
Coronavirus disease 2019 infection and subsequent cardiovascular complications
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: CORRESPONDENCE Source Type: research
Reply to ‘Blood pressure regulation is multifactorial in mitochondrial disorders’
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: CORRESPONDENCE Source Type: research
Blood pressure regulation is multifactorial in mitochondrial disorders
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: CORRESPONDENCE Source Type: research
Renal arteriovenous fistula complicated with malignant hypertension: a case report
We reported a case of RAVF presented as malignant hypertension, which was detected by contrast-enhanced ultrasonography and successfully managed by interventional embolization. A 35-year-old male was presented with a headache and blurred vision. His blood pressure was up to 220/110 mmHg, with significantly elevated serum creatinine and proteinuria. Hypertensive target organ impairments were noted. A RAVF was detected by contrast-enhanced renal ultrasonography. He underwent renal artery angiography and renal arteriovenous fistula embolization. RAAS activation was also evaluated by separate renal vein sampling. The patient...
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: CASE REPORT Source Type: research
Histological evidence supporting the durability of successful radiofrequency renal denervation in a normotensive porcine model
Conclusions:
Reductions in renal NE, cortical axon density and downstream axonal loss caused by axonal destruction persisted through 180 days post-RDN in a normotensive swine model. These results suggest functional nerve regrowth after RF RDN is unlikely and support published clinical evidence that the procedure results in durable blood pressure reduction. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Impact of 60 days of head-down bed rest on large arteries
Background:
The long-term cardiovascular consequences of microgravity on large arteries are a threat for long-term space missions. We hypothesized that changes in arterial properties differ according to the arterial territory (upper or lower body), and arterial structure (elastic vs. muscular arteries), in response to 60-day head-down bed rest (HDBR).
Method:
Twenty healthy male volunteers were included and received a daily multivitamin supplementation in a double-blind fashion. At baseline, 29 and 52 days during strict HDBR, then 12 and 30 days after HDBR, aortic stiffness was measured using carotid-to-femo...
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension
Conclusion:
NETs promote VSMCs proliferation via Akt/CDKN1b/TK1 and is related to hypertension development. Exosomes from VSMCs co-cultured with NETs participate in transferring the proliferation signal. These results support the role of NETs in the development of hypertension. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 5, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
