A healthy lifestyle is associated with lower arterial stiffness in a metabolically healthy elderly population with overweight or obesity
Conclusion:
Healthy lifestyle habits based on MedDiet adherence and regular practice of physical activity are associated with lower arterial stiffness in a metabolically healthy population with overweight or obesity older than 65 years compared with data from other elderly populations previously reported in the literature. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis
Conclusion:
We propose that PTPRD likely plays an important role in the process of pulmonary vascular remodeling and development of pulmonary hypertension in vivo. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Disentangling the varying associations between systolic blood pressure and health outcomes in the very old: an individual patient data meta-analysis
Conclusion:
While in the very old with low cognitive or physical fitness a higher SBP was associated with a lower all-cause mortality, this association was not evident in fit octogenarians. SBP was not consistently associated with cognitive and functional decline. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Excess pressure but not pulse wave velocity is associated with cognitive function impairment: a community-based study
Background:
Carotid-femoral pulse wave velocity (cf-PWV), an index of mainly distal aortic stiffness, has been inconsistently associated with cognitive function. Excess pressure, derived from the arterial reservoir-excess pressure analysis, may integrate the pulsatile load of the proximal aorta. The present study examined whether increased excess pressure is associated with cognitive function impairment in community adults.
Methods:
A total of 992 community participants (69.5% females; mean age: 67.3 years; education 13.6 years) without cerebrovascular disease or dementia received the Montreal Cognitive Asse...
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Use of initial and subsequent antihypertensive combination treatment in the last decade: analysis of a large Italian database
Conclusion:
Our data show that in a real-life population use of antihypertensive drug combinations is low. They also show that, contrary to guideline recommendations, antihypertensive combination treatment did not show any noticeable increase in recent years. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Are you as old as your arteries? Comparing arterial aging in Japanese and European patient groups using cardio-ankle vascular index
This study used the cardio-ankle vascular index (CAVI) in European compared to Japanese individuals to investigate how cardiovascular risk factors affect arterial aging across geographic regions.
Methods:
Four hundred and ninety-four European and 1044 Japanese individuals underwent measurements of CAVI, blood pressure and information on cardiovascular risk factors. Both datasets included individuals with 0–5 cardiovascular risk factors.
Results:
Average CAVI was higher in the Japanese than the European group in every age category, with significant differences up to 75 years for males and 85 for females. T...
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Arterial stiffness and nocturnal hypertension in preterm children and adolescents
Conclusion:
Preterm birth is associated with higher nocturnal BP and increased arterial stiffness in childhood and adolescence. Increased awareness for detection of hypertension and prevention of obesity in childhood could prevent future adverse cardiovascular outcomes in preterm individuals. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Time course of beat-to-beat blood pressure variability and outcome in patients with spontaneous intracerebral haemorrhage
Objectives:
Increased blood pressure variability (BPV) over 24 h or longer was associated with poor clinical outcomes in patients with intracerebral haemorrhage (ICH). However, the characteristics of beat-to-beat BPV, a rapid assessment of BPV and its association with outcome in ICH patients remain unknown.
Methods:
We consecutively and prospectively recruited patients with ICH between June 2014 and December 2020. Five-minute noninvasive beat-to-beat recordings were measured serially at three time points, 1–2, 4–6 and 10–12 days after ICH onset. BPV was calculated using standard deviation (SD) and vari...
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Sex differences in ambulatory blood pressure levels, control and phenotypes of hypertension in hemodialysis patients
Background and aims:
Ambulatory blood pressure (BP) control is worse in men than women with chronic kidney disease or kidney transplantation. So far, no study investigated possible sex differences in the prevalence, control, and phenotypes of BP according to predialysis and 48-h ambulatory blood pressure monitoring (ABPM) in hemodialysis patients. Further, no study has evaluated the diagnostic accuracy of predialysis BP in male and female hemodialysis patients.
Method:
One hundred and twenty-nine male and 91 female hemodialysis patients that underwent 48-h ABPM were included in this analysis. Hypertension was de...
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Mineralocorticoid receptor antagonism improves transient receptor potential vanilloid 4-dependent dilation of cerebral parenchymal arterioles and cognition in a genetic model of hypertension
Conclusions:
These data advance our understanding of the effects of hypertension on cerebral arterioles using a clinically relevant model and treatment paradigm. Our studies suggest TRPV4 and the MR are potential therapeutic targets to improve cerebrovascular function and cognition during hypertension. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Hypertension and clinical outcomes in patients with familial hypercholesterolemia
Background:
Hypertension is a known risk factor for cardiovascular disease; however, its impact on clinical outcomes in patients with heterozygous familial hypercholesterolemia (HeFH) is unclear. Hence, we aimed to investigate the effects of hypertension on severity of coronary artery atherosclerosis and cardiovascular outcomes in patients with HeFH.
Methods:
A total of 480 patients with clinical or molecular diagnosis of definite or probable familial hypercholesterolemia according to Dutch Lipid Clinic Network criteria (DLCN score ≥6) were included in the study. They were divided into the two groups according...
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Telemonitoring and protocolized case management for hypertensive community dwelling older adults (TECHNOMED): a randomized controlled trial
Background:
Home blood pressure (BP) telemonitoring combined with case management leads to BP reductions in individuals with hypertension. However, its benefits are less clear in older (age ≥ 65 years) adults.
Methods:
Twelve-month, open-label, randomized trial of community-dwelling older adults comparing the combination of home BP telemonitoring (HBPM) and pharmacist-led case management, vs. enhanced usual care with HBPM alone. The primary outcome was the proportion achieving systolic BP targets on 24-h ambulatory BP monitoring (ABPM). Changes in HBPM were also examined. Logistic and linear regressions were...
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Development and validation of model for sparing adrenal venous sampling in diagnosing unilateral primary aldosteronism
Conclusion:
A combination of high PAC, low PRC, low serum potassium and unilateral adrenal nodule could accurately determine primary aldosteronism subtype in 13–52% of patients with UPA and obviate the need for AVS before surgery. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Antihypertensive treatment effect on exercise blood pressure and exercise capacity in older adults
This study investigates these effects accounting for differences in exercise capacity.
Methods:
Participants enrolled in the Southall and Brent Revisited (SABRE) study undertook a 6-min stepper test with expired gas analysis and BP measured throughout exercise. Participants were stratified by antihypertensive treatment status and resting BP control. Exercise systolic and diastolic BP (exSBP and exDBP) were compared between groups using potential outcome means [95% confidence intervals (CIs)] adjusted for exercise capacity. Exercise capacity was also compared by group.
Results:
In total, 659 participants were ...
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
WNT1-inducible signalling pathway protein 1 stabilizes atherosclerotic plaques in apolipoprotein-E-deficient mice via the focal adhesion kinase/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway
Conclusion:
WISP1 not only inhibits the apoptosis of VSMCs via the PI3K/Akt/mTOR pathway but also enhances the migration and proliferation of VSMCs via the integrin α5β1 and FAK/MEK/ERK pathways. Therefore, WISP1 could enhance the stability of atherosclerotic plaques. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
