Comment on ‘Sodium-glucose co-transporter-2 inhibitors for patients with diabetic and nondiabetic chronic kidney disease’
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: CORRESPONDENCE Source Type: research
Marked intrafamilial aggregation and heritability of aortic flow in a community with prevalent volume-dependent hypertension in Africa
Aims:
Although peak aortic flow (Q) is now recognized as a major determinant of hypertension in Africa, current therapy has no proven ability to target this change. The mechanisms of this effect, therefore, require elucidation. We compared the intrafamilial aggregation and heritability of Q to that of the vascular determinants of pulse pressure (PP) and SBP in Africa.
Methods:
The intrafamilial aggregation and heritability of Q and aortic characteristic impedance (Zc) or total arterial compliance (TAC) was determined in 669 participants of 194 families (69 father–mother, 385 parent–child, 157 sibling–sibli...
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
A low aldosterone/renin ratio and high soluble ACE2 associate with COVID-19 severity
Conclusion:
High sACE2, a low aldosterone/renin ratio and having the TMPRSS2 rs2070788 non-AA genotype are novel independent determinants that may help to predict COVID-19 disease severity.
Trial registration:
retrospectively registered. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Differential biomechanics in resistance arteries of male compared with female Dahl hypertensive rats
Background:
Increase in vascular stiffness is associated with a higher risk of cardiovascular morbidity and mortality and is likely sex-specific.
Method:
Our objectives were to compare structural and functional alterations in small resistance arteries as related to vascular stiffness from Dahl salt-sensitive male and female rats (n = 8, mean ± s.e.m.).
Results:
Arterial blood pressure and pulse wave velocity were significantly (P (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Does severe subacute noise exposure increase risk of new onset hypertension beyond conventional risk factors? A 30 000 person-years cohort study
Conclusion:
Severe noise with subacute exposure is significantly associated with hypertension development. Further studies should be implemented to clarify whether severe exposure to noise could be an important risk factor for hypertension. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Comprehensive biomarker profiling of hypertension in 36 985 Finnish individuals
Objective:
Previous studies on the association between metabolic biomarkers and hypertension have been limited by small sample sizes, low number of studied biomarkers, and cross-sectional study design. In the largest study to date, we assess the cross-sectional and longitudinal associations between high-abundance serum biomarkers and blood pressure (BP).
Methods:
We studied cross-sectional (N = 36 985; age 50.5 ± 14.2; 53.1% women) and longitudinal (N = 4197; age 49.4 ± 11.8, 55.3% women) population samples of Finnish individuals. We included 53 serum biomarkers and other detailed lipoprotein...
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Renal denervation alters ambulatory blood pressure-derived salt sensitivity index in patients with uncontrolled hypertension
Conclusion:
Increased salt sensitivity after RDN may represent a compensatory mechanism to maintain renal capacity for adequate salt handling. This novel finding may have implications for patient management after RDN, such as prescription of salt moderation to further optimize RDN-induced BP-lowering efficacy. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Higher aldosterone is associated with increased renal impairment risk in patients with hypertension and abnormal glucose metabolism: a longitudinal study
Objective:
The aim of this study was to evaluate the association between plasma aldosterone concentration (PAC) and renal impairment in patients with both hypertension and abnormal glucose metabolism (AGM).
Methods:
The longitudinal observational study included 2033 hypertensive individuals with AGM who did not have chronic kidney disease (CKD) at baseline. CKD was defined as estimated glomerular filtration rate (eGFR) less than 60 ml/min per 1.73 m2 and/or positive proteinuria. Directed acyclic graphs and LASSO regression analyses were applied to identify adjusted sets. Cox proportional hazard models and li...
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Red and processed meat consumption and food insecurity are associated with hypertension; analysis of the National Health and Nutrition Examination Survey data, 2003–2016
This study examined the joint association of red and processed meat intake and food insecurity with hypertension.
Methods:
Adult participants of the National Health and Nutrition Examination Survey 2003–2016 were included. Total red meat intake was estimated using 24 h dietary recalls. Food insecurity was defined as having three or more affirmative responses using the Food Security Survey Module. Hypertension was defined as having mean SBP of at least 130 mmHg or DBP of at least 85 mmHg or use of antihypertensive drugs. Multivariable surveylogistic regression models were used to examine the independent and j...
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Incident aortic root dilatation in the general population: findings from the Pamela study
Conclusion:
The incidence of aortic root dilatation in a general middle-aged population is a relatively infrequent but not so rare event and scarcely influenced by both office and out-office BP. On the contrary, it is strongly related to LVMI (and its variations over time). From a clinical perspective, this underlines that LVH prevention and regression can reduce the risk of aortic root dilatation in the community. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
LPIN1 is a new target gene for essential hypertension
Conclusion:
The elevated BP in fld mice may result from activation of the sympathetic nervous system through decreased levels of adipose cytokines. These results indicate that LPIN1 plays a crucial role in blood pressure regulation and that LPIN1 is a new target gene for essential hypertension. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Physical exercise attenuates stress-induced hypertension in rats but not the impairments on the myocardial mechanics
Conclusion:
Despite the known benefits to the cardiovascular system, our results indicate that aerobic swimming exercise for 12 weeks reduced blood pressure but did not impede the chronic stress-induced myocardial damages in rats. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Elucidation of obstructive sleep apnoea related blood pressure surge using a novel continuous beat-to-beat blood pressure monitoring system
We examined the association of the degree of oxygen desaturation with BP surge in a given respiratory event combining all events. A total of 17 consecutive patients (12 men, mean 52 years old, nine diagnostic and eight split-night PSGs) undergoing clinically indicated PSG were included after excluding one patient with poor signal quality due to excessive movement.
Results:
Caretaker was well tolerated. Mean respiratory BP surge ranged from 5 to 19 mmHg [Median (IQR) = 13.9 (9.5--16.2)]. Mean BP surge between the respiratory and nonrespiratory events was similar [13.8 (4.5) vs. 14.9 (5.3) mmHg, P = 0.13]....
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Smooth muscle tone alters arterial stiffness: the importance of the extracellular matrix to vascular smooth muscle stiffness ratio
Conclusion:
Based on retrospective analysis of four clinical studies, we propose a simple hypothesis for the role of VSM tone on arterial stiffness: increased VSM tone increases arterial stiffness when VSM is stiffer than ECM and decreases arterial stiffness when ECM is stiffer than VSM. This hypothesis and the methods used in this study could have important implications for understanding arterial physiology in both hypertension and cardiovascular disease and deserve further exploration. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase
We examined whether VSMC-targeted overexpression of CYP4A12, the primary 20-HETE-producing enzyme in mice, is sufficient to promote hypertension.
Methods:
Mice with VSM-specific Cyp4a12 overexpression (Myh11-4a12) and their littermate controls (WT) were generated by crossbreeding Cyp4a12-floxed with Myh11-Cre mice. The 20-HETE receptor blocker, N-disodium succinate-20-hydroxyeicosa-6(Z),15(Z)-diencarboxamide (AAA), was administered in the drinking water. Experiments were carried out for 12 days. SBP was measured by tail cuff. Renal interlobar and mesenteric arteries were harvested for assessment of gene expression...
Source: Journal of Hypertension - February 2, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
