Prevalence, time-trends and clinical characteristics of hypertension in young adults: nationwide cross-sectional study of 1.7 million Swedish 18-year-olds, 1969–2010
Conclusion:
The prevalence of hypertension in young adulthood has increased substantially over time, predominantly due to an increase in ISH. Risk factor patterns differed between ISH and other forms of hypertension, suggesting potentially different underlying mechanisms. (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
New theory about the pathophysiology of preeclampsia derived from the paradox of positive effects of maternal smoking
Conclusion:
Our results partly challenge the smoking-preeclampsia paradox: smoking seems not to protect tall mothers against preeclampsia. We speculate the findings through a new theory about the pathophysiology of preeclampsia. It seems that tall pregnant smokers must raise their blood pressure aggressively to ensure perfusion in the dysfunctional placenta. (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Associations of maternal periconceptional alcohol consumption with offspring prehypertension/hypertension at age 6 years: the Growing Up in Singapore Towards healthy Outcomes prospective mother-offspring cohort study
Objective:
To evaluate the relationship of the levels of maternal alcohol consumption during the 1 year before pregnancy recognition with childhood cardiorenal, metabolic, and neurocognitive health.
Methods:
In 1106 women and their children from the Growing Up in Singapore Towards healthy Outcomes mother-offspring cohort, quantity of maternal alcohol consumption in the 12 months prior to pregnancy recognition was categorized as high (≥75th percentile: 1.9 g/day), low ( (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Persistent cardiac organ damage in surgically and medically treated primary aldosteronism
Objective:
We compared persistent cardiac organ damage in patients treated surgically or medically for primary aldosteronism.
Methods:
Eighty-four patients (age 57 ± 11 years, 27% women) with primary aldosteronism underwent echocardiography at time of diagnosis and after one year of treatment (49% adrenalectomy, 51% medical treatment). Persistent cardiac organ damage was defined as presence of left ventricle (LV) hypertrophy, low LV midwall shortening, global longitudinal strain and/or enlarged left atrium both at baseline and at follow-up.
Results:
At one year, a significant regression of LV hyper...
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Can β-blockers influence regular daily physical activity?
Background:
In hypertension, β-blockers have a high rate of nonadherence to treatment likely because of fatigue.
Methods:
We evaluate daily physical activity and maximal exercise performance in 56 patients with hypertension (grades I–II), with and without β-blockers (bisoprolol 10 mg or atenolol 100 mg) added to standard treatment; 48 patients completed the study. Study tests were performed after 8 weeks of antihypertensive therapy without β blockers and after the following 8 weeks with β-blockers.
Results:
No significant differences between β-blockers were observed. At office measurement, ...
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia
Conclusions:
The present study demonstrated the elevated levels of histone lactylation in preeclamptic placentas and identified fibrosis-related genes that were promoted by histone lactylation induced by hypoxia in trophoblast cells, which provides novel insights into the mechanism of placental dysfunction in preeclampsia. (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
11C-Metomidate PET-CT versus adrenal vein sampling to subtype primary aldosteronism: a prospective clinical trial
Conclusion:
In our pilot study, 11C-Metomidate PET-CT performed comparably to AVS, and this should be validated in larger studies. PET identified patients with unilateral primary aldosteronism missed on AVS, and these tests could be used together to identify more patients with unilateral primary aldosteronism.
Video Abstract:
http://links.lww.com/HJH/B918. (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Influences of achieved SBP on age and sex-related left ventricular structural alteration in community hypertensive populations
Objective:
To evaluate age and sex-related left ventricular (LV) structural alteration in community hypertensive populations, and to explore whether achieved systolic blood pressure (SBP) ( (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Impact of estimated pulse wave velocity and socioeconomic status on the risk of stroke in men: a prospective cohort study
Objective:
High pulse wave velocity (PWV) and low socioeconomic status (SES) are each associated with increased risk of stroke, but clarification of the interplay between PWV, SES and the risk of stroke appears to be warranted to identify vulnerable populations at high risk of stroke. We conducted a prospective study that examined the independent and joint associations of PWV and SES with the risk of stroke in the general population.
Methods:
The current study included 2666 men aged 42–61 years, who were enrolled in the Kuopio Ischaemic Heart Disease Study cohort. Estimated PWV (ePWV), a proxy of carotid-fem...
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
A bibliometric analysis of the research on preeclampsia in the first two decades of the twenty-first century
Conclusion:
This study provides the overall landscape of science mapping in recent two decades in the field of preeclampsia, with the aim of identifying evolution of research topics and promoting potential concentration or collaboration in the future. (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Persistent vascular dysfunction following an acute nonpharmacological reduction in blood pressure in hypertensive patients
Background:
Vascular dysfunction, an independent risk factor for cardiovascular disease, often persists in patients with hypertension, despite improvements in blood pressure control induced by antihypertensive medications.
Methods:
As some of these medications may directly affect vascular function, this study sought to comprehensively examine the impact of reducing blood pressure, by a nonpharmacological approach (5 days of sodium restriction), on vascular function in 22 hypertensive individuals (14 men/8 women, 50 ± 10 years). Following a 2-week withdrawal of antihypertensive medications, two 5-day dieta...
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Orthostatic hypotension and mortality risk in geriatric outpatients: the impact of duration and magnitude of the blood pressure drop
Conclusion:
The presence of DPOH and the magnitude of both systolic and diastolic orthostatic hypotension are related to an increased mortality risk in geriatric outpatients. Whether the duration of orthostatic hypotension and magnitude of the drop in blood pressure is causally related to mortality risk or whether it is a sign of decreased resilience remains to be elucidated. (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Aortic diastolic pressure decay explains sex-related differences in the subendocardial viability ratio: the Wakuya study
Objective:
Coronary heart disease is the leading cause of mortality in women. Despite a higher risk of heart failure after the first myocardial infarction in women compared with men, the sex-specific mechanisms are unknown. We hypothesized that myocardial ischemia is attributable to sex-related diastolic alterations in the central hemodynamics.
Methods:
We investigated the subendocardial viability ratio (myocardial oxygen supply/demand) and aortic diastolic pressure decay index in 962 apparently healthy adults (mean age, 56 ± 10 years). Using noninvasive applanation tonometry, the subendocardial viability...
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Inter-individual variations in response to aerobic and resistance training in hypertensive older adults
Background:
Hemodynamic responses to physical training are not homogenous and uniform, and considerable inter-individual variations in the blood pressure of hypertensive individuals are noted in both aerobic and resistance training protocols. In this context, this study aimed to evaluate the effects of resistance and aerobic exercise on the blood pressure responses of hypertensive older adults.
Methods:
Groups were randomly divided into resistance training, n = 20; aerobic training, n = 20; control group, n = 21). After the first intervention period (12 weeks), individuals underwent a washout perio...
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
From epidemiological observations to clinical practice: is the measure of postural blood pressure abnormal changes the new vital sign?
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: EDITORIAL COMMENT Source Type: research
