International Journal of Biological Macromolecules This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Constructing network structures to enhance stability and target deposition of selenium nanoparticles via amphiphilic sodium alginate and alkyl glycosides
In this study, sodium alginate (SA) and lysozyme (LZ) were reacted via the wet-heat Maillard reaction (MR) to obtain amphiphilic alginate-based polymers (SA-LZ). Alkyl glycosides (APG) were introduced into SA-LZ to enhance the deposition of SeNPs in leaves. Thus, a renewable and degradable polysaccharide-based material (SA-LZ/APG) loaded with Se formed an amphiphilic alginate-based-based shell with a Se core. Notably, the encapsulation of SeNPs into a polysaccharide base (SA-LZ/APG) increased the stabilization of SeNPs and resulted in orange-red, zero-valent, monoclinic and spherical SeNPs with a mean diameter of approxima...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Xiaona Su Wenyan Liu Bei Yang Shujuan Yang Jinjian Hou Gaobo Yu Yuhong Feng Jiacheng Li Source Type: research

Antimicrobial polysaccharide hydrogels embedded with methyl- β-cyclodextrin/thyme oil inclusion complexes for exceptional mechanical performance and chilled chicken breast preservation
This study highlights the potential of MCD/TO-IC-incorporated polysaccharide hydrogels as safe and effective active packaging solutions for preserving chilled chicken in food industry.PMID:38615861 | DOI:10.1016/j.ijbiomac.2024.131586 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Mingshan Chen Zhiyu Hu Haoyuan Zheng Jiesheng Wang Xiaowen Xu Source Type: research

Amylopectin chain length distributions and amylose content are determinants of viscoelasticity and digestibility differences in mung bean starch and proso millet starch
This study aimed to reveal the underlying mechanisms of the differences in viscoelasticity and digestibility between mung bean starch (MBS) and proso millet starch (PMS) from the viewpoint of starch fine molecular structure. The contents of amylopectin B2 chains (14.94-15.09 %), amylopectin B3 chains (14.48-15.07 %) and amylose long chains (183.55-198.84) in MBS were significantly higher than PMS (10.45-10.76 %, 12.48-14.07 % and 70.59-88.03, respectively). MBS with higher amylose content (AC, 28.45-31.80 %) not only exhibited a lower weight-average molar mass (91,750.65-128,120.44 kDa) and R1047/1022 (1.1520-1.1904), but ...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Jiawei Qiao Min Jia Jiahui Niu Zhuo Zhang Bao Xing Yongqiang Liang Hai Li Yaowen Zhang Guixing Ren Peiyou Qin Lizhen Zhang Source Type: research

Unlocking the potential of nanocarrier-mediated mRNA delivery across diverse biomedical frontiers: A comprehensive review
Int J Biol Macromol. 2024 Apr 12:131139. doi: 10.1016/j.ijbiomac.2024.131139. Online ahead of print.ABSTRACTMessenger RNA (mRNA) has gained marvelous attention for managing and preventing various conditions like cancer, Alzheimer's, infectious diseases, etc. Due to the quick development and success of the COVID-19 mRNA-based vaccines, mRNA has recently grown in prominence. A lot of products are in clinical trials and some are already FDA-approved. However, still improvements in line of optimizing stability and delivery, reducing immunogenicity, increasing efficiency, expanding therapeutic applications, scalability and manu...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Smita Pawar Prashant Pingale Atul Garkal Riyaz Ali M Osmani Kavita Gajbhiye Madhur Kulkarni Krutika Pardeshi Tejal Mehta Amarjitsing Rajput Source Type: research

Exploring the potential of chitosan/aragonite biocomposite derived from cuttlebone waste: Elaboration, physicochemical properties and in vitro bioactivity
Int J Biol Macromol. 2024 Apr 12:131554. doi: 10.1016/j.ijbiomac.2024.131554. Online ahead of print.ABSTRACTCuttlefish bone biowaste is a potential source of a composite matrix based on chitin and aragonite. In the present work, we propose for the first time the elaboration of biocomposites based on chitosan and aragonite through the valorization of bone waste. The composition of the ventral and dorsal surfaces of bone is well studied by ICP-OES. An extraction process has been applied to the dorsal surface to extract β-chitin and chitosan with controlled physico-chemical characteristics. In parallel, aragonite isolation w...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Youssef Ait Hamdan Samia Elouali Hassane Oudadesse Bertrand Lefeuvre Mohammed Rhazi Source Type: research

Enzymatic biosynthesis of D-galactose derivatives: Advances and perspectives
This study focuses on recent advancements in enzymatic biosynthesis of galactose derivatives. Various strategies including isomerization, epimerization, transgalactosylation, and phosphorylation-dephosphorylation were extensively discussed under the perspectives of thermodynamic feasibility, theoretical yield, cost-effectiveness, and by-product elimination. Specifically, the enzymatic phosphorylation-dephosphorylation cascade is a promising enzymatic synthesis route for galactose derivatives because it can overcome the thermodynamic equilibrium of isomerization and utilize cost-effective raw materials. The study also eluci...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Juanjuan Liu Xinming Feng Likun Liang Liqin Sun Dongdong Meng Source Type: research

Modulation of bacterial membranes and cellular macromolecules by dimethyl sulfoxide: A dose-dependent study providing novel insights
Int J Biol Macromol. 2024 Apr 12:131581. doi: 10.1016/j.ijbiomac.2024.131581. Online ahead of print.ABSTRACTUsing Escherichia coli as a model, this manuscript delves into the intricate interactions between dimethyl sulfoxide (DMSO) and membranes, cellular macromolecules, and the effects on various aspects of bacterial physiology. Given DMSO's wide-ranging use as a solvent in microbiology, we investigate the impacts of both non-growth inhibitory (1.0 % and 2.5 % v/v) and slightly growth-inhibitory (5.0 % v/v) concentrations of DMSO. The results demonstrate that DMSO causes alterations in bacterial membrane potential, influe...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Sinem Tun çer Rafig Gurbanov Source Type: research

Exploring glycans as vital biological macromolecules: A comprehensive review of advancements in biomedical frontiers
Int J Biol Macromol. 2024 Apr 12:131511. doi: 10.1016/j.ijbiomac.2024.131511. Online ahead of print.ABSTRACTThis comprehensive review delves into the intricate landscape of glycans and glycoconjugates, unraveling their multifaceted roles across diverse biological dimensions. From influencing fundamental cellular processes such as signaling, recognition, and adhesion to exerting profound effects at the molecular and genetic levels, these complex carbohydrate structures emerge as linchpins in cellular functions and interactions. The structural diversity of glycoconjugates, which can be specifically classified into glycoprote...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Kanika Arora P M Sherilraj K A Abutwaibe Bharti Dhruw Shyam Lal Mudavath Source Type: research

Corn cob nanocellulose packaging for increasing the shelf life of food products
Int J Biol Macromol. 2024 Apr 11:131403. doi: 10.1016/j.ijbiomac.2024.131403. Online ahead of print.ABSTRACTStudies were carried out to develop eco-friendly Packaging material for the extended shelf-life of food products. The current study sought to improve the coated bioactive film's hydrophobicity and antimicrobial properties by preparing active packaging based on biodegradable Poly Lactic Acid (PLA) containing 1 wt% Nanocellulose (NC) and various loadings of essential oil-prepared nanocomposites. Nanocellulose (NC) from Maize Cob was used as filler in the synthesis of nanopolymers enriched with Thyme oil, Cinnamon oil, ...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: E Cheran C Sharmila Rahale P Divyabharathi C Viswanathan Lakshmi Narayanan Source Type: research

Fabrication, structure, characterization and emulsion application of citrate agar
Int J Biol Macromol. 2024 Apr 11:131451. doi: 10.1016/j.ijbiomac.2024.131451. Online ahead of print.ABSTRACTCitric acid esterified agar (CA) with different degrees of substitution (DS) was prepared, and CA gel was used to stabilize O/W emulsions. Compared with native agar (NA), CA had lower gel strength, higher transparency, and higher water contact angle. Further analysis of DS, group content ratio, Fourier transform infrared, and nuclear magnetic resonance data showed that the CA underwent cross-linking reaction. Emulsion properties revealed that CA gel emulsion (CAGE) had smaller particle size and lower ζ-potential tha...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Feng Jiang Xinwei Xu Qiong Xiao Zhenyi Li Huifen Weng Fuquan Chen Anfeng Xiao Source Type: research

AgNPs loaded adenine-modified chitosan composite POSS-PEG hybrid hydrogel with enhanced antibacterial and cell proliferation properties for promotion of infected wound healing
Int J Biol Macromol. 2024 Apr 11:131575. doi: 10.1016/j.ijbiomac.2024.131575. Online ahead of print.ABSTRACTWound healing is a dynamic and complex process, it's urgent to develop new wound dressings with excellent performance to promote wound healing at the different stages. Here, a novel composite hydrogel dressing composed by silver nanoparticles (AgNPs) impregnated adenine-modified chitosan (CS-A) and octafunctionalized polyhedral oligomeric silsesquioxane (POSS) of benzaldehyde-terminated polyethylene glycol (POSS-PEG-CHO) solution was presented to solve the problem of wound infection. Modification of chitosan with ade...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Cong Zhou Tao Jiang Siju Liu Yingjie He Guichun Yang Junqi Nie Feiyi Wang Xiaofan Yang Zhenbing Chen Cuifen Lu Source Type: research

Tailoring the interfacial microenvironment of magnetic metal-organic frameworks using amino-acid-based ionic liquids for lipase immobilization
Int J Biol Macromol. 2024 Apr 11:131500. doi: 10.1016/j.ijbiomac.2024.131500. Online ahead of print.ABSTRACTModifying the carrier interface is a promising method to improve the microenvironment of immobilized enzymes and enhance their activity and stability. In this work, using proline as amino acid, magnetic metal-organic frameworks (MOFs) were modified with an amino-acid-based ionic liquid (AAIL) with two hydroxyl groups followed by adsorption of porcine pancreatic lipase (PPL). The activity recovery of the prepared immobilized lipase (MMOF-AAIL/PPL) was up to 162 % higher than that of MMOF-PPL (70.8 %). The Michaelis co...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Lili Xu Qi Qi Huanruo Liu Qi Li Xinyue Geng Xiangnan Liu Shu Chen Xuekun Wang Hongbo Suo Source Type: research

Pickering nanoemulsion loaded with eugenol contributed to the improvement of konjac glucomannan film performance
Int J Biol Macromol. 2024 Apr 11:131495. doi: 10.1016/j.ijbiomac.2024.131495. Online ahead of print.ABSTRACTKonjac glucomannan (KGM) is becoming a very potential food packaging material due to its good film-forming properties and stability. However, KGM film has several shortcomings such as low mechanical strength, strong water absorption, and poor self-antibacterial performance, which limits its application. Therefore, in order to enhance the mechanical and functional properties of KGM film, this study prepared Pickering nanoemulsion loaded with eugenol and added it to the KGM matrix to explore the improvement effect of P...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Hui Wang Dan Yuan Qingran Meng Yunchong Zhang Xingran Kou Qinfei Ke Source Type: research

Physicochemical, structural and biological characterisation of poly(3-hydroxyoctanoate) supplemented with diclofenac acid conjugates - Harnessing the potential in the construction of materials for skin regeneration processes
This study involved creating oligomeric conjugates of 3-hydroxy fatty acids and diclofenac, named Dic-oligo(3HAs). Advanced NMR techniques confirmed no free diclofenac in the mix. We tested diclofenac release under conditions resembling healthy and chronic wound skin. These oligomers were used to make P(3HO) blends, forming patches for drug delivery. Their preparation used the solvent casting/porogen leaching (SCPL) method. The patches' properties like porosity, roughness, and wettability were thoroughly analysed. Antimicrobial assays showed that Dic-oligo(3HAs) exhibited antimicrobial activity against reference (S. aureus...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Katarzyna Hara źna Annabelle T Fricker Rafa ł Konefał Aneta Medaj Ma łgorzata Zimowsk Bartosz Leszczy ński Andrzej Wr óbel Andrzej J Bojarski Ipsita Roy Maciej Guzik Source Type: research

Coarse-grained modeling and dynamics tracking of nanoparticles diffusion in human gut mucus
Int J Biol Macromol. 2024 Apr 11:131434. doi: 10.1016/j.ijbiomac.2024.131434. Online ahead of print.ABSTRACTThe gastrointestinal (GI) tract's mucus layer serves as a critical barrier and a mediator in drug nanoparticle delivery. The mucus layer's diverse molecular structures and spatial complexity complicates the mechanistic study of the diffusion dynamics of particulate materials. In response, we developed a bi-component coarse-grained mucus model, specifically tailored for the colorectal cancer environment, that contained the two most abundant glycoproteins in GI mucus: Muc2 and Muc5AC. This model demonstrated the effect...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Liming Zhao Sandra L Arias Warren Zipfel Ilana L Brito Jingjie Yeo Source Type: research