International Journal of Biological Macromolecules This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Chitosan coated selenium: A versatile nano-delivery system for molecular cargoes
Int J Biol Macromol. 2024 Apr 8:131176. doi: 10.1016/j.ijbiomac.2024.131176. Online ahead of print.ABSTRACTThe use of nanoscale delivery platforms holds tremendous potential to overcome the current limitations associated with the conventional delivery of genetic materials and hydrophobic compounds. Therefore, there is an imperative need to develop a suitable alternative nano-enabled delivery platform to overcome these limitations. This work reports the first one-step hydrothermal synthesis of chitosan functionalized selenium nanoparticles (Selenium-chitosan, SeNP) that are capable of serving as a versatile nanodelivery pla...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Edwin Davidson Jorge Pereira Sebastian Leon Ernesto Navarro Saritha Raman Kavalappara Zachary Murphy Vasileios Anagnostopoulos Sudeep Bag Swadeshmukul Santra Source Type: research

Improving and controlling the drug loading capacity of seven quinolones in minced fish matrix based on microfluidics
Int J Biol Macromol. 2024 Apr 8:131188. doi: 10.1016/j.ijbiomac.2024.131188. Online ahead of print.ABSTRACTTraditional spiking methods for preparing matrix reference material of aquatic products is difficult to control the drug content in the matrix, especially one matrix containing multiple drugs. Minced fish is commonly used for the preparation of matrix reference materials in aquatic products, which is a relatively complex matrix with stickiness and difficult handling. Drug loading capacity is a key factor affecting the effectiveness of matrix reference materials. Here, we proposed a new spiking approach to improve the ...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Chaoying Zhang Huijiao Wang Jincheng Li Huiwu Sun Huan Liu Source Type: research

Mucoadhesive chitosan-poly (lactic-co-glycolic acid) nanoparticles for intranasal delivery of quetiapine - Development & amp; characterization in physiologically relevant 3D tissue models
Int J Biol Macromol. 2024 Apr 8:131491. doi: 10.1016/j.ijbiomac.2024.131491. Online ahead of print.ABSTRACTQuetiapine hemifumarate (QF) delivery to the CNS via conventional formulations is challenging due to poor solubility and lower oral bioavailability (9 %). Similarly, many other second-generation antipsychotics, such as olanzapine, clozapine, and paliperidone, have also shown low oral bioavailability of <50 %. Hence, the present work was intended to formulate QF-loaded biodegradable PLGA-NPs with appropriate surface charge modification through poloxamer-chitosan and investigate its targeting potential on RPMI-2650 c...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Dnyandev G Gadhave Mural Quadros Akanksha R Ugale Mimansa Goyal Seyoum Ayehunie Vivek Gupta Source Type: research

Research progress and future development potential of Flammulina velutipes polysaccharides in the preparation process, structure analysis, biology, and pharmacology: A review
Int J Biol Macromol. 2024 Apr 8:131467. doi: 10.1016/j.ijbiomac.2024.131467. Online ahead of print.ABSTRACTIn recent years, Flammulina velutipes (F. velutipes) has attracted consequential attention in various research fields due to its rich composition of proteins, vitamins, amino acids, polysaccharides, and polyphenols. F. velutipes polysaccharides (FVPs) are considered as key bioactive components of F. velutipes, demonstrating multiple physiological activities, including immunomodulatory, anti-inflammatory, and antibacterial properties. Moreover, they offer health benefits such as antioxidant and anti-aging properties, w...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Shiying Ye Yi Gao Xiangyan Hu Jiye Cai Shaowei Sun Jinhuan Jiang Source Type: research

Improved antioxidant activity of pretreated lignin nanoparticles: Evaluation and self-assembly
This study investigated the effect of various pretreatment methods on the lignin structure and subsequent antioxidant activity of LNPs. Among four pretreated LNPs, hydrothermal LNPs exhibited the highest antioxidant activity, surpassing unpretreated, acid-pretreated and kraft LNPs, with an impressive efficacy of 91.6 %. The relationship between LNPs' structure and antioxidant activity was revealed by 2D heteronuclear singular quantum correlation (1H13C HSQC) and 31P nuclear magnetic resonance (NMR). 1H13C HSQC suggested the cleavage of β-O-4 ether bonds, as well as a decrease in ferulic acid and p-coumaric acid, which dir...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Mingfu Li Yingchuan Zhang Hongli Ma Qida Peng Douyong Min Pingjun Zhang Liqun Jiang Source Type: research

Characterization of carboxylated cellulose nanofibrils and oligosaccharides from Kraft pulp fibers and their potential elicitor effect on the gene expression of Capsicum annuum
In this study, cellulose nanofibrils (CNF) gels were obtained by TEMPO-mediated oxidation of unbleached and bleached kraft pulps. The molecular structures were characterized with ESI and MALDI MS. Analysis of the fine sequences was achieved by MS and MS/MS of the water-soluble oligosaccharides obtained by acid hydrolysis of the CNF gels. The analysis revealed the presence of two families: one corresponding to homoglucuronic acid sequences and the other composed by alternating glucose and glucuronic acid units. The CNF gels, alone or with the addition of the water-soluble oligosaccharides, were tested on Chili pepper (Capsi...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Mar ía Emilia Cano Åsa Lindgren Jennifer Rosendahl Jenny Johansson Alberto Garcia-Martin Miguel Ladero Galan Jos é Kovensky Gary Chinga-Carrasco Source Type: research

Postbiotics-enriched flaxseed mucilage coating: A solution to improving postharvest quality and shelf life of strawberry
Int J Biol Macromol. 2024 Apr 6:131398. doi: 10.1016/j.ijbiomac.2024.131398. Online ahead of print.ABSTRACTThis research aimed to assess the effects of flaxseed mucilage (Mu) coatings supplemented with postbiotics (P) obtained from Lactobacillus acidophilus LA-5 on various physical, biochemical, and microbial characteristics of strawberry fruits. Strawberry fruits were immersed for 2 min in Mu2.5 (2.5 % mucilage in distilled water), Mu5 (5 % mucilage in distilled water), P-Mu2.5 (2.5 % mucilage in undiluted postbiotics) and P-Mu5 (5 % mucilage in undiluted postbiotics) solutions and were stored at 4 °C and 85 RH for 12 da...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Houshmand Sharafi Abolfazl Alirezalu Shao-Quan Liu Azad Karami Mehran Moradi Source Type: research

Characterization of O/W emulgels based on whey protein-alginate-inulin coacervates: Influence of temperature and ultrasound as protein preconditioning process
Int J Biol Macromol. 2024 Mar 30:131260. doi: 10.1016/j.ijbiomac.2024.131260. Online ahead of print.ABSTRACTPreconditioning processes in proteins play a crucial role in enhancing their functional properties as surface active agents. Whey protein isolate (WPI, 20 wt%) was preconditioned via temperature (WPIT, 90 °C) or ultrasound (WPIUS, 20 kHz, 80 % amplitude). FTIR and zeta potential analysis demonstrated the effect of the preconditioning process on the secondary structure and surface properties of WPI. WPI-Alginate:Inulin (AI) complex coacervates (CCWPI:AI) were formed at pH 3.0 using WPIT and WPIUS, and the associative...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Anthony M Ortiz-Dele ón Ang élica Román-Guerrero Ofelia Sandoval-Castilla Juan Carlos Cuevas-Bernardino Source Type: research

MFTrans: A multi-feature transformer network for protein secondary structure prediction
Int J Biol Macromol. 2024 Apr 8:131311. doi: 10.1016/j.ijbiomac.2024.131311. Online ahead of print.ABSTRACTIn the rapidly evolving field of computational biology, accurate prediction of protein secondary structures is crucial for understanding protein functions, facilitating drug discovery, and advancing disease diagnostics. In this paper, we propose MFTrans, a deep learning-based multi-feature fusion network aimed at enhancing the precision and efficiency of Protein Secondary Structure Prediction (PSSP). This model employs a Multiple Sequence Alignment (MSA) Transformer in combination with a multi-view deep learning archi...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Yifu Chen Guanxing Chen Calvin Yu-Chian Chen Source Type: research

Higher specific capacitance and compressibility nanocellulose based supercapacitor hydrogel electrode assembled by efficient impregnation
Int J Biol Macromol. 2024 Apr 8:131463. doi: 10.1016/j.ijbiomac.2024.131463. Online ahead of print.ABSTRACTThe rational and effective combination of different electrochemical substances to prepare high-performance supercapacitor electrodes has been widely studied by researchers. Currently, most work focuses on polymerizing conductive polymers onto the surface of nanocellulose and carbon materials, and then preparing them into supercapacitor electrodes. This method is effective, but the process is cumbersome. Therefore, we propose a simpler and more effective method. A hydrogel was prepared by using TEMPO oxidized cellulose...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Xingwang Wang Yehong Chen Chaojun Wu Source Type: research

Efficient isomerization of glucose into fructose by MgO-doped lignin-derived ordered mesoporous carbon
This study introduces an innovative synthesis method for creating an MgO-based ordered mesoporous carbon (MgO@OMC) catalyst, aimed at the efficient isomerization of glucose into fructose. Throughout the synthesis process, lignin serves as the exclusive carbon precursor, while Mg2+ functions as both a crosslinking agent and a metallic active center. This enables a one-step synthesis of MgO@OMC via a solvent-induced evaporation self-assembly (EISA) method. The synthesized MgO@OMCs exhibit an impeccable 2D hexagonal ordered mesoporous structure, in addition to a substantial specific surface area (378.2 m2/g) and small MgO nan...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Zhibin Han Xiaoqi Wang Xiaolan Zhao Feng Shen Boxiong Shen Xinhua Qi Source Type: research

Modification of wood lignin and integration with multifunctional polyester nanocomposite
Int J Biol Macromol. 2024 Apr 8:131466. doi: 10.1016/j.ijbiomac.2024.131466. Online ahead of print.ABSTRACTA simple strategy was introduced to develop fluorescent wood with the ability to alter its color when exposed to both visible and ultraviolet lights. Injecting a combination of europium and dysprosium doped aluminate (EDA; 7-12 nm) nanoparticles and polyester resin (PET) into a lignin-modified wood (LMW) produced a translucent smart wooden window with fluorescence and afterglow emission properties. In order to prevent formation of aggregates and improve the preparation process of transparent wood, EDA must be properly...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Marzough A Albalawi Source Type: research

Alginate-based adsorbents with adjustable slit-shaped pore structure for selective removal of copper ions
In this study, GO, MMT and SA were used as raw materials to compare the adsorption behaviors of three alginate-based adsorbents crosslinked with different valence metal ions (Ca2+, Fe3+ and Zr4+) on Cu(II). The aerogels were based on sodium alginate as the matrix material with unique slit-shaped pore structures formed by stacking effect of sheets and chemical bonding. It was found that the pore structures of the aerogels were denser and more orderly with the increase of the valence states of the crosslinked ions, and the affinity for Cu(II) in planar configuration was stronger. The Zr4+-GMSA aerogel had the maximum adsorpt...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Suya Li Jie Hao Shuyi Yang Yuanfei Wang Yun Li E Tao Source Type: research

Opportunity for a greener recovery of dysprosium(III) from secondary sources by a novel Mannich reaction-modified phosphorylated chitosan hydrogel
Int J Biol Macromol. 2024 Apr 8:131449. doi: 10.1016/j.ijbiomac.2024.131449. Online ahead of print.ABSTRACTThe depleting supply of natural sources of rare earth elements (REE) is a concern to many nations as demand for advanced technology is becoming vital for national security. In this communication, the recovery of dysprosium(III) from aqueous systems was exemplified by a modified phosphorylated chitosan (PCs/MB) prepared by the C-Mannich reaction of phosphorylated chitosan, glutaraldehyde, and 4-hydroxycoumarin in ethanolic solution. Batch adsorption studies achieved a maximum adsorption capacity (qmax) of 34 mg/g at 25...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: John Rey Apostol Romal Say Kee Ong Source Type: research

In vitro digestion properties of Laiyang pear residue polysaccharides and it counteracts DSS-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier
Int J Biol Macromol. 2024 Apr 8:131482. doi: 10.1016/j.ijbiomac.2024.131482. Online ahead of print.ABSTRACTThe aim of this study was to explore the dynamic changes in the physicochemical properties of Laiyang pear residue polysaccharide (LPP) during in vitro digestion, as well as its protective effect on the intestines. Monosaccharide composition and molecular weight analysis showed that there was no significant change in LPP during the oral digestion stage. However, during the gastric and intestinal digestion stages, the glycosidic bonds of LPP were broken, leading to the dissociation of large molecular aggregates and a s...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Liqing Fan Xiangyang Zhu Dexi Zhang Dapeng Li Chen Zhang Source Type: research