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An endometrial biomimetic extracellular matrix (ECM) for enhanced endometrial regeneration using hyaluronic acid hydrogel containing recombinant human type III collagen
Int J Biol Macromol. 2024 Apr 20;268(Pt 1):131723. doi: 10.1016/j.ijbiomac.2024.131723. Online ahead of print.ABSTRACTEndometrial injury poses a significant challenge in tissue regeneration, with type III collagen (COL III) playing a pivotal role in maintaining endometrial integrity and facilitating repair. Our study explored the utility of recombinant human type III collagen (RHC) as an intervention for endometrial damage. To address the challenges associated with the inherent instability and rapid degradation of COL III in vivo, we developed an RHC-HA hydrogel by conjugating RHC with hyaluronic acid (HA), thus ensuring a...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Siying Wei Ziyi Li Huan Xia Zhaoyang Wang Jingxian Deng Lu Li Rufei Huang Tao Ye Yadong Huang Yan Yang Source Type: research

Valorization of edible films based on chitosan/hydroxyethyl cellulose/olive leaf extract and TiO < sub > 2 < /sub > -NPs for preserving sour cream
Int J Biol Macromol. 2024 Apr 20:131727. doi: 10.1016/j.ijbiomac.2024.131727. Online ahead of print.ABSTRACTBiodegradable edible films for sour cream packaging were developed based on chitosan (CS), hydroxyethyl cellulose (HEC), Olive leaf extract (OE), and titanium dioxide nanoparticles (TiO2-NPs). The prepared CS/HEC/TiO2-OE bionanocomposite films were evaluated for their antimicrobial and antioxidant activities as well as using FT-IR, mechanical, permeability, and contact angle. The effect of developed films on the lipid oxidation, microbiological load, and chemical properties of sour cream was investigated. The fabrica...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Samah M El-Sayed Hoda S El-Sayed Ayat F Hashim Ahmed M Youssef Source Type: research

Improved antioxidant and anti-tubercular potential of liquiritigenin grafted on low molecular weight chitosan from gladius of Sepioteuthis lessoniana
In conclusion the in vitro antioxidant and the anti-tuberculosis (anti-TB) properties of the grafted samples were significantly (P < 0.001) increased compared to the unconjugated LMW-CH and LTG. Overall, functionalization of LTG with LMW-CH improved the anti-tuberculosis activity. Further studies are needed to explore the possibilities of its use in vivo models.PMID:38649074 | DOI:10.1016/j.ijbiomac.2024.131728 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Katriel Erica Aavula Thabitha Kesavarao Kumar Ebenezar Swastik Satyapal Ankit Kumar Vijayakumar Abishek Narayansami Mohana Priya Gururaja Perumal Pazhani Saravanan Ramachandran Source Type: research

Synthesis, characterization and column adsorption properties of gum ghatti and water hyacianth derived cellulose grafted poly(vinyl sulfonic acid-co-acrylamide) composites
Int J Biol Macromol. 2024 Apr 20:131652. doi: 10.1016/j.ijbiomac.2024.131652. Online ahead of print.ABSTRACTVinylsulfonic acid (VSA), acrylamide (AM) and N, N methylene bis acrylamide(MBA) were copolymerized by radical polymerization in the presence of gum ghatti (GG) and treated water hyacianth (WH) in water. Several composite copolymers were prepared by varying the i) AM: VSA molar ratios ii) wt% of GG and iii) wt% of treated WH based on a Box-Behnken Design(BBD) of a response surface methodology (RSM) model with three input variables and the batch adsorption capacity (mg/g) of 100 mg/L Cd (II) from water as response. Th...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Jayabrata Maity Samit Kumar Ray Source Type: research

Caffeic acid combined with arabinoxylan or β-glucan attenuates diet-induced obesity in mice via modulation of gut microbiota and metabolites
Int J Biol Macromol. 2024 Apr 20:131683. doi: 10.1016/j.ijbiomac.2024.131683. Online ahead of print.ABSTRACTPolyphenols and dietary fibers in whole grains are important bioactive compounds to reduce risks for obesity. However, whether the combination of the two components exhibits a stronger anti-obesity effect remains unclear. Caffeic acid is a major phenolic acid in cereals, and arabinoxylan and β-glucan are biological macromolecules with numerous health benefits. Here, we investigated the effect of caffeic acid combined with arabinoxylan or β-glucan on glucose and lipid metabolism, gut microbiota, and metabolites in m...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Wei Fang Mingyu Jin Wentao Qi Chunli Kong Ge Song Wenting Peng Yong Wang Source Type: research

Production, modification and degradation of fructans and fructooligosacharides by enzymes originated from plants
Int J Biol Macromol. 2024 Apr 20:131668. doi: 10.1016/j.ijbiomac.2024.131668. Online ahead of print.ABSTRACTNon-starch polysaccharides exhibit numerous beneficial health effects but compounds belonging to FODMAP (Fermentable Oligo- Di- and Monosaccharides and Polyols) has been recently connected to several gastrointestinal disorders. This review presents integrated literature data on the occurrence and types of fructans and fructooligosaccharids (classified as FODMAPs) as well as their degrading enzymes present in plants. Plants from the family Asteraceae and many monocotyledones, including families Poaceae and Liliaceae, ...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Milo š Radosavljević Miona Belovi ć Aleksandra Cvetanovi ć Kljakić Aleksandra Torbica Source Type: research

Hierarchical mesoporous silicon and albumin composite microparticles delivering DOX and FU for liver cancer treatment
Int J Biol Macromol. 2024 Apr 20;268(Pt 1):131732. doi: 10.1016/j.ijbiomac.2024.131732. Online ahead of print.ABSTRACTDrug delivery systems based on hydrogel microcarriers have shown enormous achievements in tumor treatment. Current research direction mainly concentrated on the improvement of the structure and function of the microcarriers to effectively deliver drugs for enhanced cancer treatment with decreased general toxicity. Herein, we put forward novel hierarchical mesoporous silicon nanoparticles (MSNs) and bovine serum albumin (BSA) composite microparticles (MPMSNs@DOX/FU) delivering doxorubicin (DOX) and 5-fluorou...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Tianyuan Xu Lu Fan Li Wang Haozhen Ren Qingfei Zhang Weijian Sun Source Type: research

Structural basis for the recognition of IFNAR1 by the humanized therapeutic monoclonal antibody QX006N for the treatment of systemic lupus erythematosus
Int J Biol Macromol. 2024 Apr 20:131721. doi: 10.1016/j.ijbiomac.2024.131721. Online ahead of print.ABSTRACTInterferon (IFN) alpha/beta receptor 1 (IFNAR1) is indispensable for antiviral responses and the immune regulation. Dysregulation of the IFNAR1-mediaetd signaling pathways leads to deleterious autoimmune diseases such as systemic lupus erythematosus (SLE). QX006N, a humanized therapeutic monoclonal antibody, specifically targets human IFNAR1 and is in the clinical trial phase for treating SLE, but the molecular mechanism underlying the QX006N-mediated recognition of IFNAR1 remains unclear. Here, we report the high ne...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Xiaorong Chen Huimin Ke Wei Li Lu Yin Wei Chen Tao Chen Yiliang Wu Jiwan Qiu Wei Feng Source Type: research

Ascorbic acid biosynthesis in Pacific abalone Haliotis discus hannai Ino and L-gulonolactone oxidase gene loss as an independent event
In conclusion, the present study provided direct evidence to prove that the GLO activity and the ability to synthesize AA exist in abalone. The AA synthesis ability in vertebrates might have originated from invertebrates dating back 930.31 million years.PMID:38649080 | DOI:10.1016/j.ijbiomac.2024.131733 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Kai Luo Xiaojun Yu Jia Wang Jiahuan Liu Xinxin Li Mingzhu Pan Dong Huang Kangsen Mai Wenbing Zhang Source Type: research

Sourcing chitin from exoskeleton of Tenebrio molitor fed with polystyrene or plastic kitchen wrap
Int J Biol Macromol. 2024 Apr 20:131731. doi: 10.1016/j.ijbiomac.2024.131731. Online ahead of print.ABSTRACTIn this work we have characterized and compared chitin sourced from exoskeleton of Tenebrio molitor larvae fed with polystyrene or plastic kitchen wrap combined with bran in the ratio 1: 1 with chitin sourced from larvae exoskeleton fed only with bran. Analysis of the frass by ATR-FTIR showed very similar spectra and confirmed degradation of the plastic feed components, while ATR-FTIR analysis of the exoskeleton verified the absence of any plastic residue. Deproteinization followed by demineralization produced 6.78-5...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Larisa Ilijin Maria Vesna Nikoli ć Zorka Z Vasiljevi ć Dajana Todorovi ć Marija Mrdakovi ć Milena Vlahovi ć Dragana Mati ć Nenad B Tadi ć Vesna Peri ć-Mataruga Source Type: research

Gelatin nanocarriers assembled by a self-immolative cross-linker for targeted cancer therapy
Int J Biol Macromol. 2024 Apr 20;268(Pt 1):131722. doi: 10.1016/j.ijbiomac.2024.131722. Online ahead of print.ABSTRACTWith a number of outstanding properties, gelatin is an ideal candidate for assembling nanoplatforms in biomedical applications. Generally, gelatin nanocarriers are cross-linked by aldehydes to improve their stability in water solution. However, aldehydes could cause multiple toxicities and their cross-linking products are uncontrollable. Here, we first used a self-immolative cross-linker to assemble gelatin nanocarriers for the controlled release of drugs and targeted cancer therapy. The cross-linker contai...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Jingtong Wang Zhao Li Yajing Chen Ningbin Luo Shengbin He Source Type: research

Liver glycogen fragility in the presence of hydrogen-bond breakers
Int J Biol Macromol. 2024 Apr 20;268(Pt 1):131741. doi: 10.1016/j.ijbiomac.2024.131741. Online ahead of print.ABSTRACTGlycogen, a complex branched glucose polymer, is responsible for sugar storage in blood glucose homeostasis. It comprises small β particles bound together into composite α particles. In diabetic livers, α particles are fragile, breaking apart into smaller particles in dimethyl sulfoxide, DMSO; they are however stable in glycogen from healthy animals. We postulate that the bond between β particles in α particles involves hydrogen bonding. Liver-glycogen fragility in normal and db/db mice (an animal mode...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Xinle Tan Ziyi Wang Ut Cheung Zhenxia Hu Qinghua Liu Liang Wang Mitchell A Sullivan Daniel Cozzolino Robert G Gilbert Source Type: research

Potential inhibitory effect of highland barley protein hydrolysates on the formation of advanced glycation end-products (AGEs): A mechanism study
Int J Biol Macromol. 2024 Apr 19:131632. doi: 10.1016/j.ijbiomac.2024.131632. Online ahead of print.ABSTRACTAdvanced glycation end products (AGEs) can be caused during a glycoxidation reaction. This reaction is associated with complications of diabetes and the consequences of health problems. Therefore, we are exploring the prohibitory effect of highland barley protein hydrolysates (HBPHs) on AGE formation. Herein, first extracted the protein from highland barley with various pH conditions and then hydrolyzed using four different proteolytic enzymes (flavourzyme, trypsin, papain, pepsin) under different degrees of hydrolys...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Su Hlaing Phyo Mohamed Ghamry Guina Bao Aoqiong Zeng Wei Zhao Source Type: research

Oleic acid decorated kraft lignin as a hydrophobic and functional filler of cellulose acetate films
This study investigated using lignin (pristine and esterified) as a functional additive of cellulose acetate. The effect of varying concentrations of pristine kraft and oleic acid functionalized lignin in the cellulose acetate matrix and its effect on the resulting film's mechanical, morphological, viscoelastic, and water barrier properties were explored. Comprehensive characterization of the thermomechanical processed lignin-cellulose acetate sheets revealed reduced moisture absorption, improved UV and moisture barrier, and enhanced tensile properties with melt processability. Overall, the studied films could have appeali...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Rohan Shorey Tizazu H Mekonnen Source Type: research

Effect of different molecular weight β-glucan hydrated with highland barley protein on the quality and in vitro starch digestibility of whole wheat bread
This study investigated the effects of β-glucan and highland barley protein of different molecular weights (2 × 104, 1 × 105, and 3 × 105 Da) and different hydrate methods (pre-hydrate and not pre-hydrate) on the characteristics of whole wheat dough and bread. The mixing properties and rheological properties demonstrated that β-glucan pre-hydrated with highland barley protein were able to reduce the dough tan δ, reduce the dough viscoelasticity, while enhance the gluten network structure and dough deformation resistance. Compared to the control sample, the medium molecular weight pre-hydrate bread had a better specif...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Mengfei Gao Zhongbo Hu Yueyue Yang Zhengyu Jin Aiquan Jiao Source Type: research