International Journal of Biological Macromolecules 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Shaping sustainable pathways: Enhancing mechanical properties of biocomposite through tannic acid treatment of flax fabrics
Int J Biol Macromol. 2024 Apr 4:131393. doi: 10.1016/j.ijbiomac.2024.131393. Online ahead of print.ABSTRACTBiocomposites developed using natural fibers serve as a sustainable alternative to synthetic composite materials. However, narrowing the performance gap between synthetic composites and biocomposites requires serious efforts. A promising approach is the modification of natural fibers using various chemical treatments. This paper investigates the potential of tannic acid (TA) treatment as a sustainable approach to enhance mechanical performance and reduce moisture absorption of flax fabric-reinforced biocomposites. The...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Muhammad Shoaib Butt Khubab Shaker M Ayub Asghar Adeel Abbas Yasir Nawab Shahid Rasul Source Type: research
Elucidation of antioxidant activities of intracellular and extracellular polysaccharides from Cordyceps militaris in vitro and their protective effects on ulcerative colitis in vivo
In this study, we extracted the polysaccharides from C. militaris fruiting bodies (CFIPs), mycelial intracellular polysaccharides (CMIPs), and fermentation broth extracellular polysaccharides (CFEPs) to investigate their physicochemical properties, antioxidant capacities, and effects on oxazolone-induced zebrafish ulcerative colitis (UC). Our results revealed differences in monosaccharide composition and surface structure among CFIPs, CMIPs, and CFEPs. The molar ratios of glucose to mannose in CFIPs, glucose to xylose in CMIPs, and xylose to glucose in CFEPs were 7.57: 1.6, 7.26: 1.81, and 5.44: 2.98 respectively. Moreover...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Yangbian Guo Yin Wei Chang Liu Hao Li Xiao Du Junlong Meng Jingyu Liu Qi Li Source Type: research
Chitosan-based hybrid nanospheres for vessel normalization towards enhancing tumor chemotherapy
Int J Biol Macromol. 2024 Apr 4:131409. doi: 10.1016/j.ijbiomac.2024.131409. Online ahead of print.ABSTRACTVessel normalization has proved imperative in tumor growth inhibition. In this work, biopolymer-based hybrid nanospheres capable of normalizing blood vessels were designed to improve the therapeutic effect of chemotherapeutic drugs. Zn0.4Fe2.6O4 nanoparticles (ZFO NPs) were synthesized, and were encapsulated in cross-inked chitosan (CS) along with a nitric oxide (NO) precursor, DETA NONOate, forming hybrid ZFO/NO@CS nanospheres highly stable in physiological environment. The structure, morphology and size of the nanos...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Ding Wang Yaoqing Chu Shuiping Liu Lianjiang Tan Source Type: research
Cellulose nanofiber-based multifunctional composite films integrated with zinc doped-grapefruit peel-based carbon quantum dots
This study aimed to develop a multifunctional active composite film to extend the shelf life of minced pork. The composite film was prepared by incorporating zinc-doped grapefruit peel-derived carbon quantum dots (Zn-GFP-CD) into a cellulose nanofiber (CNF) matrix. The resulting film significantly improved UV-blocking properties from 39.0 % to 85.7 % while maintaining the film transparency. Additionally, the CNF/Zn-GFP-CD5% composite film exhibits strong antioxidant activity with ABTS and DPPH radical scavenging activities of 99.8 % and 77.4 %, respectively. The composite film also showed excellent antibacterial activity a...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Su Jung Hong Seong Yong Ha Gye Hwa Shin Jun Tae Kim Source Type: research
Fabrication of cellulose-collagen based biosorbent as eco-friendly scavengers for uranyl ions
Int J Biol Macromol. 2024 Apr 4:131400. doi: 10.1016/j.ijbiomac.2024.131400. Online ahead of print.ABSTRACTThe aim of the present research is to fabricate a biosorbent using agricultural waste for removal of uranium from contaminated water i.e. "waste to wealth" approach. Cellulose extracted from wheat straw was mercerized and a novel semi-interpenetrating polymer network (semi-IPN) was fabricated through graft copolymerization of polyvinyl alcohol onto hybrid mercerized cellulose + collagen backbone. Response surface methodology was used for optimization of different reaction parameters as a function of % grafting (195.1 ...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Himani Sharma Balbir Singh Kaith Rakesh Kumar Rohit Mehra Manpreet Singh Bhatti Source Type: research
Effect of electric field on physicochemical properties and resistant starch formation in ohmic heating processed corn starch
In this study, the conductivity values at 120 °C were measured at 1.5 mS/m. The study revealed two distinct outcomes resulting from the application of different EFS. Firstly, a thermal effect induced gelatinization, resulting in a reduction in the enthalpy of corn starch, an increase in the water absorption index (WAI) and the water solubility index (WSI), and a decrease in peak viscosity. Secondly, a non-thermal effect of OH was observed, leading to the electrolysis of certain starch compounds and water. This electrolysis process generated radicals (-OH) that interacted with starch components, augmenting the percentage o...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Francisco M Flores-Garc Ãa Eduardo Morales S ánchez Marcela Gayt án-MartÃnez Gonzalo Vel ázquez de la Cruz Ma Guadalupe Del Carmen M éndez Montealvo Source Type: research
Characterization of a multi-domain exo- β-1,3-galactanase from Paenibacillus xylanexedens
Int J Biol Macromol. 2024 Apr 4:131413. doi: 10.1016/j.ijbiomac.2024.131413. Online ahead of print.ABSTRACTβ-1,3-Galactanases selectively degrade β-1,3-galactan, thus it is an attractive enzyme technique to map high-galactan structure and prepare galactooligosaccharides. In this work, a gene encoding exo-β-1,3-galactanase (PxGal43) was screened form Paenibacillus xylanexedens, consisting of a GH43 domain, a CBM32 domain and α-L-arabinofuranosidase B (AbfB) domain. Using β-1,3-galactan (AG-II-P) as substrate, the recombined enzyme expressed in Escherichia coli BL21 (DE3) exhibited an optimal activity at pH 7.0 and 30 Â...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Hao Liu Min Huang Shuxin Wei Xiaowen Wang Yaqing Zhao Zhengyang Han Xianfeng Ye Zhoukun Li Yanling Ji Zhongli Cui Yan Huang Source Type: research
SARS-CoV-2 M < sup > pro < /sup > oligomerization as a potential target for therapy
In this study, we utilized biochemical, structural, and molecular modelling approaches to explore Mpro dimerization. We evaluated critical residues, specifically Arg4 and Arg298, that are essential for dimerization. Our results show that changes in the oligomerization state of Mpro directly affect its enzymatic activity and dimerization propensity. We discovered a synergistic relationship influencing dimer formation, involving both intra- and intermolecular interactions. These findings highlight the potential for developing allosteric inhibitors targeting Mpro, offering promising new directions for therapeutic strategies.P...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Kinga Lis Jacek Plewka Filipe Menezes Ewa Bielecka Yuliya Chykunova Katarzyna Pustelny Stephan Niebling Angelica Struve Garcia Maria Garcia-Alai Grzegorz M Popowicz Anna Czarna Tomasz Kantyka Krzysztof Pyrc Source Type: research
Gum odina prebiotic induced gut modulation for the treatment of colon cancer on Swiss albino mice: By using capecitabine loaded biopolymeric microsphere
Int J Biol Macromol. 2024 Apr 4:131410. doi: 10.1016/j.ijbiomac.2024.131410. Online ahead of print.ABSTRACTA complex illness with a current global hazard, colon cancer has many different manifestations. The efficacy of colon cancer therapy can be affected by the bacteria in the digestive tract. It is hypothesised that novel prebiotics like Gum Odina is emerging as preventative therapy to fight chronic gut illnesses by gut microbiota modulatory therapy when compared to traditional intervention. The first-line chemotherapy drug for colon cancer, capecitabine, lacks a carrier that can extend its half-life. Here, we use the pr...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Ahana Hazra Mousumi Tudu Abhishek Mohanta Amalesh Samanta Source Type: research
Reconstructing dynamics correlation network to simultaneously improve activity and stability of 2,3-butanediol dehydrogenase by design of distal interchain disulfide bonds
This study provided important insights into the relationship among dynamics, enzyme catalysis and stability, and will be useful in the designing new enzymes with co-evolution of stability, activity and selectivity.PMID:38582485 | DOI:10.1016/j.ijbiomac.2024.131415 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Zhongji Pu Jiawen Cao Wenhui Wu Zhongdi Song Lirong Yang Jianping Wu Haoran Yu Source Type: research
A colorimetric and fluorescent probe of lignocellulose nanofiber composite modified with Rhodamine 6G derivative for reversible, selective and sensitive detection of metal ions in wastewater
Int J Biol Macromol. 2024 Apr 4:131416. doi: 10.1016/j.ijbiomac.2024.131416. Online ahead of print.ABSTRACTHeavy metal ions have extremely high toxicity. As the top of food chain, human beings certainly will accumulate them by ingesting food and participating other activities, which eventually result in the damage to our health. Therefore, it is very meaningful and necessary to design a simple, portable, stable and efficient material for heavy metal ions detection. Based on the spirolactam Rhodamine 6G (SRh6G) fluorescent probe, we prepared two types of nanocomposite materials (membrane and aerogel) by vacuum filtration an...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Zhenghui Li Ming Zhang Congcong An Haiyue Yang Lijuan Feng Zexin Cui Meihui Shi Dingqiang Zheng Shoufu Long Dongsheng Song Source Type: research
Binding mechanism of pentamidine derivatives with human serum acute phase protein α < sub > 1 < /sub > -acid glycoprotein
Int J Biol Macromol. 2024 Apr 4:131405. doi: 10.1016/j.ijbiomac.2024.131405. Online ahead of print.ABSTRACTDrug binding and interactions with plasma proteins play a crucial role in determining the efficacy of drug delivery, thus significantly impacting the overall pharmacological effect. AGP, the second most abundant plasma protein in blood circulation, has the unique capability to bind drugs and transport various compounds. In our present study, for the first time, we investigated whether AGP, a major component of the acute phase lipocalin in human plasma, can bind with pentamidine derivatives known for their high activit...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Teresa Żołek Orsolya D ömötör Jerzy Żabiński Source Type: research
Corrigendum to "In-situ visualizing selective lignin dissolution of tracheids wall in reaction wood" [Int. J. Biol. Macromol. 222 (Part A) (1 December 2022) 691-700]
Int J Biol Macromol. 2024 Apr 5;266(Pt 2):131353. doi: 10.1016/j.ijbiomac.2024.131353. Online ahead of print.NO ABSTRACTPMID:38581979 | DOI:10.1016/j.ijbiomac.2024.131353 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Linxin Dai Jiajun Wang Xing-E Liu Qianli Ma Benhua Fei Jianfeng Ma Zhi Jin Source Type: research
In vivo absorption, in vitro simulated digestion and fecal fermentation properties of polysaccharides from Pinelliae Rhizoma Praeparatum Cum Alumine and their effects on human gut microbiota
In this study, the absorption, digestion and fermentation properties of PPA were studied using in vivo fluorescence tracking, in vitro simulated digestion and fecal fermentation experiments. The absorption experiment showed that fluorescence was only observed in the gastrointestinal system, indicating that PPA could not be absorbed. Simulated digestion results showed that there were no significant changes in the molecular weight, Fourier transform infrared spectroscopy (FT-IR) spectrum, monosaccharides and reducing sugar of PPA during the digestion process, showing that the overall structure of PPA was not damaged. However...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Kui-Xu Gao Xi Peng Jing-Ya Wang Yao Wang Ke Pei Xiang-Long Meng Shuo-Sheng Zhang Mei-Bian Hu Yu-Jie Liu Source Type: research
Bone morphogenetic protein 15 gene disruption affects the in vitro maturation of porcine oocytes by impairing spindle assembly and organelle function
Int J Biol Macromol. 2024 Apr 4:131417. doi: 10.1016/j.ijbiomac.2024.131417. Online ahead of print.ABSTRACTBone morphogenetic protein 15 (BMP15) plays a crucial role in the porcine follicular development. However, its exact functions in the in vitro maturation (IVM) of porcine oocytes remain largely unknown. Here, through cytoplasmic injection of a preassembled crRNA-tracrRNA-Cas9 ribonucleoprotein complex, we achieved BMP15 disruption in approximately 54 % of the cultured porcine oocytes. Editing BMP15 impaired the IVM of porcine oocytes, as indicated by the significantly increased abnormal spindle assembly and reduced fi...
Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Yafei Jiao Chang Bei Yixian Wang Alian Liao Jinming Guo Xinran Li Tiantuan Jiang Xiaohong Liu Yaosheng Chen Peiqing Cong Zuyong He Source Type: research
