International Journal of Biological Macromolecules This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An oral bioactive chitosan-decorated doxorubicin nanoparticles/bacteria bioconjugates enhance chemotherapy efficacy in an in-situ breast cancer model
This study introduces autopilot biohybrids (Bif@BDC-NPs) for the effective delivery of doxorubicin (DOX) to the tumor site. This hybrid combines albumin-encapsulated DOX nanoparticles (BD-NPs) coated with chitosan (CS) for breast cancer chemotherapy, along with anaerobic Bifidobacterium infantis (B. infantis, Bif) serving as self-propelled motors. Due to Bif's specific anaerobic properties, Bif@BDC-NPs precisely anchor hypoxic regions of tumor tissue and significantly increase drug accumulation at the tumor site, thereby promoting tumor cell death. In an in-situ mouse breast cancer model, Bif@BDC-NPs achieved 94 % tumor in...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Jianmei Li Qian Wen Jie Dai Biqiong Wang Yun Lu Zhouxue Wu Yu Fan Fancai Zeng Yue Chen Yan Zhang Renjin Chen Shaozhi Fu Source Type: research

Structural characterization of lytic transglycosylase MltD of Pseudomonas aeruginosa, a target for the natural product bulgecin A
Int J Biol Macromol. 2024 Apr 5:131420. doi: 10.1016/j.ijbiomac.2024.131420. Online ahead of print.ABSTRACTNatural product bulgecin A potentiates the activity of β-lactam antibiotics by inhibition of three lytic transglycosylases in Pseudomonas aeruginosa, of which MltD is one. MltD exhibits both endolytic and exolytic reactions in the turnover of the cell-wall peptidoglycan and tolerates the presence or absence of stem peptides in its substrates. The present study reveals structural features of the multimodular MltD, presenting a catalytic module and four cell-wall-binding LysM modules that account for these attributes. ...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Vega Miguel-Ruano Rhona Feltzer Mar ía T Batuecas Balajee Ramachandran Amr M El-Araby Luis F Avila-Cobian Stefania De Benedetti Shahriar Mobashery Juan A Hermoso Source Type: research

Rice starch modification by thermal treatments with avocado oil: Autoclave versus microwave methods
This study aimed to evaluate the physical and chemical alterations in rice starch modified by heat-moisture treatment (HMT) using an autoclave and a microwave, in association with avocado oil (AO), and evaluate the effects on thermal and structural properties, in vitro digestibility, and estimated glycemic index (eGI). Samples were adjusted to 30 % (w/w) moisture and 2, 4 and 8 % AO. HMT was conducted at 110 °C for 1 h in the autoclave (A0%, A2%, A4%, and A8%) and at 50 °C for 3 min in the microwave (M0%, M2%, M4%, and M8%). Both procedures did not alter the starch crystallinity pattern (type-A). Pasting viscosity, setba...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Sabrina Feksa Frasson Rosana Colussi Helen Cristina Dos Santos Hackbart Caroline Dellinghausen Borges Wladimir Hernandez Flores Carla Rosane Barboza Mendon ça Source Type: research

Novel chitosan-based smart bio-nanocomposite films incorporating TiO < sub > 2 < /sub > nanoparticles for white bread preservation
Int J Biol Macromol. 2024 Apr 5:131367. doi: 10.1016/j.ijbiomac.2024.131367. Online ahead of print.ABSTRACTChitosan (CS)-based bio-nanocomposite food packaging films were prepared via solvent-casting method by incorporating a unique combination of additives and fillers, including polyvinyl alcohol (PVA), glycerol, Tween 80, castor oil (CO), and nano titanium dioxide (TiO2) in various proportions to enhance film properties. For a comprehensive analysis of the synthesized films, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), tensile testing, field emission scanning ...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: None Geeta None Shivani Neeru Devi None Shayoraj Neha Bansal Sanjay Sharma Santosh Kumar Dubey Satish Kumar Source Type: research

Synthesis, characterization and antifungal properties of maleopimaric anhydride modified chitosan
In this study, rosin derivative maleopimaric anhydride (MPA) was combined with biodegradable and antifungal chitosan (CS) to enhance its antifungal and preservative properties. The modified compounds were characterized by FTIR, 1H NMR spectra and XRD, and the in vitro antifungal properties of the modified compounds were evaluated by the radial growth assay and the minimal inhibitory concentration assay. The preservation effect on small mandarin oranges and longan was studied. The analysis revealed that the modification product (CSMA) of MPA access to C6-OH of CS had a better antifungal effect. In addition, CSMA was more en...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Lingling Li Yanran Xu Zhuo Xu Chunhua Wu Qian Chen Kaimeng Xu Zhengjun Shi Xiaoping Rao Source Type: research

Bacterial cellulose-based hydrogel with regulated rehydration and enhanced antibacterial activity for wound healing
Int J Biol Macromol. 2024 Apr 5:131291. doi: 10.1016/j.ijbiomac.2024.131291. Online ahead of print.ABSTRACTBacterial cellulose (BC) hydrogels are promising medical biomaterials that have been widely used for tissue repair, wound healing and cartilage engineering. However, the high water content of BC hydrogels increases the difficulty of storage and transportation. Moreover, they will lose their original hydrogel structure after dehydration, which severely limits their practical applications. Introducing the bio-based polyelectrolytes is expected to solve this problem. Here, we modified BC and combined it with quaternized ...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Lili Deng Fangzhou Li Zhiliang Han Xiangyang Qu Jing Li Zhou Zhou Shiyan Chen Huaping Wang Xiangguo Lv Source Type: research

Fucoidan MF4 from Fucus vesiculosus inhibits Lewis lung cancer via STING-TBK1-IRF3 pathway
In this study, a novel fucoidan MF4 was extracted from Fucus vesiculosus and isolated using Q-Sepharose fast-flow ion-exchange chromatography. The physicochemical properties of MF4 were characterized. MF4 is primarily composed of fucose, xylose, galactose, glucose, and mannose in a molar ratio of 12.3: 4.9: 1.1: 1.0: 1.1, with an average molecular weight of 67.7 kDa. Notably, MF4 demonstrated suppression of LLC tumor growth in vivo. RNA-sequencing analysis revealed that MF4 enhanced the expression of type I interferon-associated downstream genes in macrophages. Furthermore, MF4 increased the levels of phosphorylated TBK1 a...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Chuanqin Shi Shihua Zhao Liyan Mi Deying Niu Fanwen Hu Wenwei Han Bing Li Source Type: research

A high-throughput differential scanning fluorimetry method for rapid detection of thermal stability and iron saturation in lactoferrin
Int J Biol Macromol. 2024 Apr 5:131285. doi: 10.1016/j.ijbiomac.2024.131285. Online ahead of print.ABSTRACTThermal stability and iron saturation of lactoferrin (LF) are of great significance not only for the evaluation of the biological activities of LF but also for the optimization of the isolation and drying process parameters. Differential scanning calorimetry (DSC) is a well-established and efficient method for thermal stability and iron saturation detection in LF. However, multiple DSC measurements are typically performed sequentially, thus time-consuming and low throughput. Herein, we introduced the differential scan...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Na-Na Sun Qin-Feng Xu Meng-di Yang Yan-Ni Li Hao Liu Wei Tantai Guo-Wei Shu Guo-Liang Li Source Type: research

Starch and storage protein dynamics in the developing and matured grains of durum wheat and diploid progenitor species
This study provides valuable insights into the genetic and biochemical distinctions among durum wheat and its diploid progenitors, offering a foundation for their nutritional composition.PMID:38583842 | DOI:10.1016/j.ijbiomac.2024.131177 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Megha Kaushik Ekta Mulani Amit Kumar Harsh Chauhan Manish Ranjan Saini Alka Bharti None Gayatri Yuvaraj Iyyappan Jayanthi Madhavan Amitha Mithra Sevanthi Pranab Kumar Mandal Source Type: research

Response surface optimization, purification, characterization and short-chain chitooligosaccharides production from an acidic, thermostable chitinase from Thermomyces dupontii
Int J Biol Macromol. 2024 Apr 5:131362. doi: 10.1016/j.ijbiomac.2024.131362. Online ahead of print.ABSTRACTChitin, recovered in huge amounts from coastal waste, may biocatalytically valorized for utilization in food and biotech sectors. Conventional chemical-based conversion makes use of significant volumes of hazardous acid and alkali. Alternatively, enzymes offer better process control and generation of homogeneous products. Process variables were derived to achieve augmented levels of chitinase (3.8809 Ul-1 h-1) productivity from a novel thermophilic fungal strain Thermomyces dupontii, ITCC 9104 following incubation (96...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Rajni Kumari Manish Kumar Pawan K Dadheech V Vivekanand Nidhi Pareek Source Type: research

Lignin: A multi-faceted role/function in 3D printing inks
Int J Biol Macromol. 2024 Apr 5:131364. doi: 10.1016/j.ijbiomac.2024.131364. Online ahead of print.ABSTRACT3D printing technology demonstrates significant potential for the rapid fabrication of tailored geometric structures. Nevertheless, the prevalent use of fossil-derived compositions in printable inks within the realm of 3D printing results in considerable environmental pollution and ecological consequences. Lignin, the second most abundant biomass source on earth, possesses attributes such as cost-effectiveness, renewability, biodegradability, and non-toxicity. Enriched with active functional groups including hydroxyl,...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Jian Yang Xingye An Bin Lu Haibing Cao Zhengbai Cheng Xin Tong Hongbin Liu Yonghao Ni Source Type: research

Glutenin-chitosan 3D porous scaffolds with tunable stiffness and systematized microstructure for cultured meat model
Int J Biol Macromol. 2024 Apr 6:131438. doi: 10.1016/j.ijbiomac.2024.131438. Online ahead of print.ABSTRACTA glutenin (G)-chitosan (CS) complex (G-CS) was cross-linked by water annealing with aim to prepare structured 3D porous cultured meat scaffolds (CMS) here. The CMS has pore diameters ranging from 18 to 67 μm and compressive moduli from 16.09 to 60.35 kPa, along with the mixing ratio of G/CS. SEM showed the porous organized structure of CMS. FTIR and CD showed the increscent content of α-helix and β-sheet of G and strengthened hydrogen-bondings among G-CS molecules, which strengthened the stiffness of G-CS. Raman s...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Xiao-Mei Wu Wen-Min Han Li-Yan Hou Dan-Dan Lin Jia-Ying Li Si-Tong Lin Jin-Peng Yang Lan Liao Xin-An Zeng Source Type: research

Electrospraying and electrospinning of tannic acid-loaded zein: Characterization and antioxidant effects in astrocyte culture exposed to E. coli lipopolysaccharide
Int J Biol Macromol. 2024 Apr 5:131433. doi: 10.1016/j.ijbiomac.2024.131433. Online ahead of print.ABSTRACTTannic acid (TA) exhibits low bioavailability in the gastrointestinal tract, limiting its benefits due to small amounts reaching the CNS. Thus, the objective of this study was to develop zein capsules and fibers by electrospraying/electrospinning for encapsulation of TA. Polymeric solutions were evaluated by electrical conductivity, density, and viscosity. In zein capsules, up to 2 % TA was added, and in fibers, up to 1 % TA was added. Zein capsule and fiber with TA were evaluated by morphology, size distribution, enc...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Karina Pereira Luduvico Marjana Rad ünz Helen Cristina Dos Santos Hackbart Nat ália Pontes Bona Nathalia Stark Pedra Maria Rosa Chitolina Elessandra da Rosa Zavareze Roselia Maria Spanevello Francieli Moro Stefanello Source Type: research

Investigations on physiochemical and biomedical properties of Aloe vera - Sterculia gum copolymeric dressings impregnated with antibiotic-anesthetic drugs to enhance wound healing
Int J Biol Macromol. 2024 Apr 5:131363. doi: 10.1016/j.ijbiomac.2024.131363. Online ahead of print.ABSTRACTRecently, various innovative advancements have been made in carbohydrate research to design versatile materials for biomedical applications. The current research focuses on the development of copolymeric hydrogel wound dressings (HWD) using a combination of aloe vera (AV) - sterculia gum (SG) - poly (vinylsulfonic acid) (VSA)-based with the aim to enhancing their efficacy in drug delivery (DD) applications. These hydrogel dressings were encapsulated with levofloxacin and lidocaine to address both microbial infection a...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Diwanshi Sharma Ashima Sharma Ritu Bala Baljit Singh Source Type: research

Exploring the synergistic effect of carboxymethyl cellulose and chitosan in enhancing thermal stability of polyurethanes through statistical mixture design approach
Int J Biol Macromol. 2024 Apr 5:131441. doi: 10.1016/j.ijbiomac.2024.131441. Online ahead of print.ABSTRACTThe thermal stability of polyurethanes, known for its limitations, was addressed in this research by seeking improvement through the introduction of carbohydrate-based chain extenders. In this research paper, we systematically sought to improve the thermal resistance of polyurethanes by incorporating carboxymethyl cellulose and chitosan, representing a pioneering application of the mixture design approach in their preparation. In this synthesis, hydroxyl-terminated polybutadiene and isophorone diisocyanate (IPDI) were...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Muhammad Asif Javaid Salman Arif Cheema Nadeem Nasir Saliha Ahmad Muhammad Tahir Hussain Zaighum Tanveer Muhammad Zia Ul Mustafa Usama Tahir Shehbaz Ali Source Type: research