International Journal of Biological Macromolecules This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing
In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (TAX) with a drug loading of 41.94 ± 2.60 % was prepared. In addition, it has excellent catalase activity, and by constructing an oxygen-releasing hydrogel (PTH) system with calcium peroxide (CaO2), it can be used as a nano-enzyme to promote the generation of oxygen from hydrogen peroxide (H2O2) to provide sufficient oxygen to the wound, and at the same time, solve the problem of the oxidative stress damage caused by excess H2O2 to the cells during the oxygen-releasing process. On the other hand, TAX and HKUST-1 in PTH synergistically promoted an...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Guodong Chai Ning Wang Meiling Xu Lina Ma Xinglong Liu Qiteng Ding Shuai Zhang Anning Li Guofeng Xia Yingchun Zhao Wencong Liu Dadong Liang Chuanbo Ding Source Type: research

Structure-function relationship and biological activity of polysaccharides from mulberry leaves: A review
Int J Biol Macromol. 2024 Apr 19;268(Pt 1):131701. doi: 10.1016/j.ijbiomac.2024.131701. Online ahead of print.ABSTRACTMulberry (Latin name "Morus alba L.") is a perennial deciduous tree in the family of Moraceae, widely distributed around the world. In China, mulberry is mainly distributed in the south and the Yangtze River basin. Its leaves can be harvested 3-6 times a year, which has a great resource advantage. Mulberry leaves are regarded as the homology of medicine and food traditional Chinese medicine (TCM). Polysaccharides, as its main active ingredients, have various effects, such as antioxidant, hypoglycemic, hepat...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Yexian Hu Yan Zhang Xiaoao Cui Dongsheng Wang Yong Hu Chuyan Wang Source Type: research

Characterization of polyploidy in cancer: Current status and future perspectives
Int J Biol Macromol. 2024 Apr 19:131706. doi: 10.1016/j.ijbiomac.2024.131706. Online ahead of print.ABSTRACTVarious cancers frequently exhibit polyploidy, observed in a condition where a cell possesses more than two sets of chromosomes, which is considered a hallmark of the disease. The state of polyploidy often leads to aneuploidy, where cells possess an abnormal number or structure of chromosomes. Recent studies suggest that oncogenes contribute to aneuploidy. This finding significantly underscores its impact on cancer. Cancer cells exposed to certain chemotherapeutic drugs tend to exhibit an increased incidence of polyp...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Srijonee Ghosh Debopriya Choudhury Dhruba Ghosh Meghna Mondal Didhiti Singha Pushkar Malakar Source Type: research

Cellulose supported TiO < sub > 2 < /sub > /Cu < sub > 2 < /sub > O for highly asymmetric conjugate addition of α,β-unsaturated compounds in aqueous phase
Int J Biol Macromol. 2024 Apr 19:131205. doi: 10.1016/j.ijbiomac.2024.131205. Online ahead of print.ABSTRACTA series of new kind green cellulose-supported bimetallic TiO2/Cu2O (Cell@TiO2/Cu2O) catalytic materials were obtained by in-situ reduction method employing cellulose as the carrier. The effects of metal percentage composition on the morphology and construction of the catalytic materials were systematically investigated. The Cell@TiO2/Cu2O were characterized by FT-IR, TG, XPS, SEM, TEM, EDS, and the element content was obtained by elemental analysis. Then, the achieved catalytic materials were applied to the chiral b...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Yaoyao Zhang Haifeng Guo Chengpeng Fu Weishuang Li Bojie Li Lei Zhu Source Type: research

Temporal dynamics of lignin degradation in Quercus acutissima sawdust during Ganoderma lucidum cultivation
Int J Biol Macromol. 2024 Apr 19:131686. doi: 10.1016/j.ijbiomac.2024.131686. Online ahead of print.ABSTRACTDespite a fair amount of lignin conversion during mycelial growth, previous structural analyses have not yet revealed how lignin changes continuously and what the relationship is between lignin and ligninolytic enzymes. To clarify these aspects, Quercus acutissima sawdust attaching Ganoderma lucidum mycelium collected from different growth stage was subjected to analysis of lignin structure and ligninolytic enzyme activity. Two key periods of lignin degradation are found during the cultivation of G. lucidum: hypha ra...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Peng Wang Xiaobin Feng Ziwen Lv Jia Liu Qian Teng Tong Chen Qinghong Liu Source Type: research

Protective effect of Broussonetia papyrifera leaf polysaccharides on intestinal integrity in a rat model of diet-induced oxidative stress
This study aimed to investigate the effect of Broussonetia papyrifera polysaccharides (BPP) on the jejunal intestinal integrity of rats ingesting oxidized fish oil (OFO) induced oxidative stress. Polysaccharides (Mw 16,956 Da) containing carboxyl groups were extracted from Broussonetia papyrifera leaves. In vitro antioxidant assays showed that this polysaccharide possessed antioxidant capabilities. Thirty-two male weaned rats were allocated into two groups orally infused BPP solution and PBS for 26 days, respectively. From day 9 to day 26, half of the rats in each group were fed food containing OFO, where the lipid peroxid...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Xiangqi Fan Wei Yu Qingxiang Wang Heng Yang Dayan Tan Bing Yu Jun He Ping Zheng Jie Yu Junqiu Luo Yuheng Luo Hui Yan Jianping Wang Huifen Wang Quyuan Wang Xiangbing Mao Source Type: research

Effects of turning aeration and the initial carbon/nitrogen ratio on the biodegradation of polylactic acid under controlled conditions
In this study, we assessed how turning aeration and the initial carbon/nitrogen (C/N) ratio impact PLA biodegradation. The study was carried out under controlled composting conditions, over 180 days, with the aim of decreasing the biodegradation time of the PLA. Apple pomace, rice husk, grape pomace compost, and PLA were used as substrates in the composting process. The experiments were conducted using three types of turning aeration: without turning, one turn per week, and two turns per week. Three initial C/N ratios were used: 20, 30, and 40. A stepwise temperature ramp was designed and implemented to simulate industrial...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Yvan Baldera-Moreno Camila Hern ández Aris Vargas Alejandro Rojas-Palma Rodrigo Morales-Vera Rodrigo Andler Source Type: research

Chemo-photothermal therapy of chitosan/gold nanorod clusters for antibacterial treatment against the infection of planktonic and biofilm MRSA
In this study, we developed chemo-photothermal therapy (chemo-PTT) based on near-infrared (NIR)-irradiated chitosan/gold nanorod (GNR) clusters as anti-methicillin-resistant Staphylococcus aureus (MRSA) agents. The nanocomposites exhibited an average size of 223 nm with a surface charge of 36 mV. These plasmonic nanocomposites demonstrated on-demand and rapid hyperthermal action under NIR. The combined effect of positive charge and PTT by NIR-irradiated nanocomposites resulted in a remarkable inhibition rate of 96 % against planktonic MRSA, indicating a synergistic activity compared to chitosan nanoparticles or GNR alone. ...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: G R Nirmal Zih-Chan Lin Tai-Sheng Chiu Ahmed Alalaiwe Chia-Chih Liao Jia-You Fang Source Type: research

Design, synthesis and in vitro evaluation of novel thiazole-coumarin hybrids as selective and potent human carbonic anhydrase IX and XII inhibitors
Int J Biol Macromol. 2024 Apr 18:131548. doi: 10.1016/j.ijbiomac.2024.131548. Online ahead of print.ABSTRACTThe coumarin is one of the most promising classes of non-classical carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. In continuation of our ongoing work on search of coumarin based selective carbonic anhydrase inhibitors, a new series of 6-aminocoumarin based 16 novel analogues of coumarin incorporating thiazole (4a-p) have been synthesized and studied for their hCA inhibitory activity against a panel of human carbonic anhydrases (hCAs). Most of these newly synthesized compounds exhibited interesting inhibition constan...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Priti Singh Sridhar Goud Nerella Baijayantimala Swain Andrea Angeli Qasim Ullah Claudiu T Supuran Mohammed Arifuddin Source Type: research

Development of chitosan/polycaprolactone-thymol Janus films with directional transport and antibacterial properties for meat preservation
This study aims to develop a novel active packaging material for meat preservation by precisely controlled dual-channel one-step electrospinning. Compared to traditional strategies of preparing Janus films, this method allows for greater flexibility and efficiency. The structure and properties of the Janus film are characterized by scanning electron microscopy (SEM), water contact angle (WCA), directional liquid transport investigation, Thymol release and permeation features, and biocompatibility evaluation. Moreover, the Janus film is applied to the packaging of pork with modified atmosphere packaging to demonstrate its p...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Zhaozhang Zhu Lingna Meng Zhennan Gao Rongxu Liu Xiang Guo Hao Wang Baohua Kong Source Type: research

A highly efficient blocking ELISA based on p72 monoclonal antibody for the detection of African swine fever virus antibodies and identification of its linear B cell epitope
Int J Biol Macromol. 2024 Apr 18:131695. doi: 10.1016/j.ijbiomac.2024.131695. Online ahead of print.ABSTRACTDue to the absence of effective vaccine and treatment, African swine fever virus (ASFV) control is entirely dependent on accurate and early diagnosis, along with culling of infected pigs. The B646L/p72 is the major capsid protein of ASFV and is an important target for developing a diagnostic assays and vaccines. Herein, we generated a monoclonal antibody (mAb) (designated as 2F11) against the trimeric p72 protein, and a blocking ELISA (bELISA) was established for the detection of both genotype I and II ASFV antibodie...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Weldu Tesfagaber Wan Wang Lulu Wang Rui Zhao Yuanmao Zhu Fang Li Encheng Sun Renqiang Liu Zhigao Bu Geng Meng Dongming Zhao Source Type: research

High extraction and excellent anti-UV and anti-oxidant proprieties of lignin from Reseda Luteola L. waste by organosolv process
Int J Biol Macromol. 2024 Apr 18:131624. doi: 10.1016/j.ijbiomac.2024.131624. Online ahead of print.ABSTRACTLignin is an abundant natural biopolymer found in plant cell walls. Lignin can come from tinctorial plants, whose residual biomass after dye extraction was typically discarded as waste. The main objective of this study was to extract lignin from the residual biomass of Reseda luteola L. using an organosolv process and to optimize the extraction conditions. The extracted lignin was characterized, and its potential applications as an antimicrobial, anti-oxidant, and anti-UV agent were investigated. Response surface met...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Ali Zourif Oumaima Chajii Younes Chemchame Asmaa Benbiyi Zineb Azoubi Mohamed El Guendouzi Abdeslam El Bouari Source Type: research

O-linked glycosylations in human milk casein and major whey proteins during lactation
This study aimed to identify and analyze O-linked glycans in HM by high-throughput mass spectrometry. 184 longitudinal HM samples from 66 donors from day 3 and months 1, 2, and 3 postpartum were subjected to a post-translational modification specific enrichment-based strategy using TiO2 and ZrO2 beads for O-linked glycopeptide enrichment. β-CN was found to be a major O-linked glycoprotein, additionally, αS1-CN, κ-CN, lactotransferrin, and albumin also contained O-linked glycans. As glycosyltransferases and glycosidases are involved in assembling the glycans including O-linked glycosylations, these were further investiga...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Martin N ørmark Thesbjerg Katrine Overgaard Poulsen Julie Astono Nina Aagaard Poulsen Lotte Bach Larsen S øren Drud-Heydary Nielsen Allan Stensballe Ulrik Kr æmer Sundekilde Source Type: research

A review of biomacromolecule-based 3D bioprinting strategies for structure-function integrated repair of skin tissues
This study provides a comprehensive overview of various biopolymer-based inks, with a particular emphasis on chitosan (CS), starch, alginate, agarose, cellulose, and fibronectin, all of which are natural polymers belonging to the category of biomacromolecules. Additionally, it summarizes artificially synthesized polymers capable of enhancing the performance of these biomacromolecule-based bioinks, thereby composing hybrid biopolymer inks aimed at better application in skin tissue engineering endeavors. This review paper examines the recent advancements, characteristics, benefits, and limitations of biological 3D bioprintin...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Hao Liu Fei Xing Peiyun Yu Man Zhe Xin Duan Ming Liu Zhou Xiang Ulrike Ritz Source Type: research

3D poly(L-lactic acid) fibrous sponge with interconnected porous structure for bone tissue scaffold
Int J Biol Macromol. 2024 Apr 18:131688. doi: 10.1016/j.ijbiomac.2024.131688. Online ahead of print.ABSTRACTLarge bone defects, often resulting from trauma and disease, present significant clinical challenges. Electrospun fibrous scaffolds closely resembling the morphology and structure of natural ECM are highly interested in bone tissue engineering. However, the traditional electrospun fibrous scaffold has some limitations, including lacking interconnected macropores and behaving as a 2D scaffold. To address these challenges, a sponge-like electrospun poly(L-lactic acid) (PLLA)/polycaprolactone (PCL) fibrous scaffold has ...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Chen Meng Xuzhao Liu Renzhi Li Samira Malekmohammadi Yangyang Feng Jun Song R Hugh Gong Jiashen Li Source Type: research