Enzymatic biosynthesis of D-galactose derivatives: Advances and perspectives

This study focuses on recent advancements in enzymatic biosynthesis of galactose derivatives. Various strategies including isomerization, epimerization, transgalactosylation, and phosphorylation-dephosphorylation were extensively discussed under the perspectives of thermodynamic feasibility, theoretical yield, cost-effectiveness, and by-product elimination. Specifically, the enzymatic phosphorylation-dephosphorylation cascade is a promising enzymatic synthesis route for galactose derivatives because it can overcome the thermodynamic equilibrium of isomerization and utilize cost-effective raw materials. The study also elucidates the existing challenges and future trends in enzymatic biosynthesis of galactose derivatives. Collectively, this review provides a real-time summary aimed at promoting the practical biosynthesis of galactose derivatives through enzymatic catalysis.PMID:38615865 | DOI:10.1016/j.ijbiomac.2024.131518

Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Juanjuan Liu Xinming Feng Likun Liang Liqin Sun Dongdong Meng Source Type: research