Having a Good Time Together: The Role of Companionship in Older Couples ’ Everyday Life
This article studies time-varying associations of companionship with emotional and relational well-being as older couples engage in their everyday life.Methods: Participants provided three data points a day over 7 days using electronic surveys that were simultaneously completed by both partners. A total of 118 older heterosexual couples reported momentary companionship, positive and negative affect, and closeness. Data were analyzed using an intensive longitudinal dyadic score model.Results: Couples with higher average companionship showed lower overall negative affect, more overall positive affect, and higher overall clos...
Source: Gerontology - April 25, 2022 Category: Geriatrics Source Type: research
Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF- κB Axis in a YTHDF2-Dependent Manner
Conclusion: Collectively, we first identified that D+Q alleviate LPS-induced senescence in HUVECs via the TRAF6-MAPK-NF- κB axis in a YTHDF2-dependent manner, providing novel ideas for clinical treatment of age-related cardiovascular diseases.Gerontology (Source: Gerontology)
Source: Gerontology - April 25, 2022 Category: Geriatrics Source Type: research
Prospective Study of Ageing Trajectories in the European DO-HEALTH Study
Conclusion: We observed dynamic trajectories of ageing where transitioning to a healthier state became less likely with advancing age and among women.Gerontology (Source: Gerontology)
Source: Gerontology - April 20, 2022 Category: Geriatrics Source Type: research
KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1
Conclusion: KLF7 bound to the HDAC4 promoter to activate HDAC4, inhibit miR-148b-3p via reducing acetylation level, and promote NCOR1 transcription, thereby limiting GMR in macrophages and alleviating AS lesions.Gerontology (Source: Gerontology)
Source: Gerontology - April 19, 2022 Category: Geriatrics Source Type: research
Frailty and Suicidality in Older Adults: A Mini-Review and Synthesis
The prevalence of frailty, which is significantly associated with late-life suicidality, increases with age in older adults. This review addresses the compiled evidence on the relationship between suicidality and frailty within older populations, explores the latest findings, weighs the effectiveness of various intervention strategies, and outlines potential future investigations in this area. Growing evidence suggests that identifying and addressing risk factors, including mood disorders, prior suicide attempts, poor physical health, and social isolation/problems can decrease the risk of late-in-life suicide. Various stud...
Source: Gerontology - April 13, 2022 Category: Geriatrics Source Type: research
Time Spent Away from Bed to Maintain Swallowing Function in Older Adults
Conclusion: Spending 4 or more hours away from the bed is related to appendicular skeletal muscle mass and FOIS, while spending 6 or more hours is related to appendicular skeletal muscle mass, trunk muscle mass, and FOIS in this population. These findings highlight factors that can prevent a decline in swallowing function in the daily life of older adults with low ADL who have difficulty performing exercises to preserve swallowing function.Gerontology (Source: Gerontology)
Source: Gerontology - April 12, 2022 Category: Geriatrics Source Type: research
Gender Differences in Mental Health, Quality of Life, and Caregiver Burden among Informal Caregivers during the Second Wave of the COVID-19 Pandemic in Germany: A Representative, Population-Based Study
Conclusion: Female informal caregivers were more negatively affected than male informal caregivers during the pandemic, as indicated by higher levels of anxiety and lower quality of life. Gender differences in anxiety depended on the perceived danger posed by the pandemic. Thus, policy and pandemic measures should focus on gender-specific support of female caregivers who seem to be particularly vulnerable during the pandemic. More caregiver-specific support and information around protecting themselves and their care recipients are recommended. Also, further research on gender differences in care performance and their relat...
Source: Gerontology - April 7, 2022 Category: Geriatrics Source Type: research
Elderly Patients with Moderate-To-Severe Ulcerative Colitis Are More Likely to Have Treatment Failure and Adverse Outcome
Conclusion: Elderly patients with moderate-to-severe UC experienced more treatment failure and increased risk of UC-related colectomy, mortality, and severe infections, predicting demand for more strict and individualized management.Gerontology (Source: Gerontology)
Source: Gerontology - April 6, 2022 Category: Geriatrics Source Type: research
Changes in Health Expectancy for Older Adults in Japan: Results from Two Longitudinal Surveys
Conclusions: Our results show that the health status of older adults in Japan has largely improved over the 10-year study period, with increases in both the duration of life and time spent in an active state. This finding offers evidence of compression of morbidity among older men and women in Japan.Gerontology (Source: Gerontology)
Source: Gerontology - March 28, 2022 Category: Geriatrics Source Type: research
Methods of Assessing Frailty in the Critically Ill: A Systematic Review of the Current Literature
Conclusions: Frailty assessment on the ICU is heterogeneous with respect to methods, cut-offs, and time points. The CFS may best reflect frailty in the ICU. Frailty assessments should be harmonized and performed routinely in the critically ill.Gerontology (Source: Gerontology)
Source: Gerontology - March 25, 2022 Category: Geriatrics Source Type: research
Left Atrial Phasic Function in Older Adults Is Associated with Fibrotic and Low-Grade Inflammatory Pathways
Conclusion: By advanced CMR imaging, a panel of circulating biomarkers comprising galectin, MMP-9 and sUPAR were associated with left atrial dysfunction in older adults. Higher levels of Gal-3 and MMP-9 may be suggestive of fibrotic mechanisms in left atrial aging while impairments in left atrial strain seen in association with circulating sUPAR may be related to immune activation in the left atrium in response to left atrial remodeling and fibrotic processes.Gerontology (Source: Gerontology)
Source: Gerontology - March 22, 2022 Category: Geriatrics Source Type: research
Association of Anemia with Dementia and Cognitive Decline among Community-Dwelling Elderly
Conclusions and implications: Anemia in community-dwelling elders appears to be associated with an increased DCD risk in a dose-response manner. Application of the WHO anemia criteria in men may miss patients with mild anemia that places them at DCD risk. Further research should look at anemia as a cause of reversible dementia.Gerontology (Source: Gerontology)
Source: Gerontology - March 22, 2022 Category: Geriatrics Source Type: research
COVID-19 Outbreaks in Nursing Homes Despite Full Vaccination with BNT162b2 of a Majority of Residents
Conclusions: Outbreaks of COVID-19, including severe cases and deaths, can still occur in NH despite full vaccination of a majority of residents. Vaccine remains highly effective, however, for preventing severe disease and death. Prevention and control measures for SARS-CoV-2 should be maintained in NH at periods of high incidence in the community.Gerontology (Source: Gerontology)
Source: Gerontology - March 21, 2022 Category: Geriatrics Source Type: research
Anaemia Is Associated with an Increased Risk of Fractures, a Systematic Review, and Meta-Analysis
Conclusion: Our results suggest that there is a significant relationship between anaemia and fracture risk in older adults. This association is stronger among older men than women and differs in the different types of fractures.Gerontology (Source: Gerontology)
Source: Gerontology - March 21, 2022 Category: Geriatrics Source Type: research
Effects of Exergaming on Physical and Cognitive Outcomes of Older Adults Living in Long-Term Care Homes: A Systematic Review
Conclusions: Exergames might be a promising intervention to benefit the physical health of OAs (#x3e;65 years) living in LTC, but more research is required to determine the effects of exergaming on physical health, as well as cognitive and QoL outcomes. More specifically, larger and more methodologically robust evaluations are needed.Gerontology (Source: Gerontology)
Source: Gerontology - March 15, 2022 Category: Geriatrics Source Type: research
