Connected and Automated Vehicles: Chances for Elderly Travellers
Connected and automated vehicles (CAV) are expected to improve the mobility of older people by compensating for the effects of a decreasing age-related fitness to drive. However, the technology is still under development and it is unclear how automated transport services will be implemented and which effects will be achievable. This paper aims to assess the potential of connected and automated transport to improve the mobility of older people. The discussion focuses on potentially disrupting highly automated services; in addition, general effects on the transport system and quality of life influenced by the increased mobil...
Source: Gerontology - May 22, 2019 Category: Geriatrics Source Type: research

Age-Dependent Changes in the Cochlea
Age-related hearing loss is a progressive, bilateral, and symmetrical sensorineural hearing loss due to degeneration of inner ear structures and it is considered a multifactorial complex disorder. Changes in tissue performance act from the cellular level to the molecular level. Histological visible damage in different structures of the inner ear signifies that the high frequency region is more sensitive and earlier affected. For many years it has been known that, with advancing age, there is an increasing loss of outer and inner hair cells and peripheral and central neurons. Furthermore, it comes to an atrophy of the stria...
Source: Gerontology - May 22, 2019 Category: Geriatrics Source Type: research

Clinical, Electrocardiographic, and Echocardiographic Features in Hospitalized Nonagenarians (90+): Comparison between the Genders
Conclusions: We found a remarkable presence of cardiovascular risk factors, ECG, and structural alterations in hospitalized nonagenarians, which presents more commonly in males.Gerontology (Source: Gerontology)
Source: Gerontology - May 22, 2019 Category: Geriatrics Source Type: research

Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in < b > < i > Caenorhabditis elegans < /i > < /b > Model of Aging and Age-Related Disease
Conclusions: These data indicated that rBTI might promote the autophagy to alleviate the age-related functional decline via DAF-16 inC. elegans and suggested a potential role of rBTI as a nutraceutical for the improvement of age-related complications.Gerontology (Source: Gerontology)
Source: Gerontology - May 22, 2019 Category: Geriatrics Source Type: research

The Adapted Lifestyle-Integrated Functional Exercise Program for Preventing Functional Decline in Young Seniors: Development and Initial Evaluation
Conclusion: aLiFE has the potential to engage young seniors in regular lifestyle-integrated activities. Effectiveness needs to be evaluated in a randomized controlled trial.Gerontology (Source: Gerontology)
Source: Gerontology - May 22, 2019 Category: Geriatrics Source Type: research

A Mini-Review of Virtual Reality-Based Interventions to Promote Well-Being for People Living with Dementia and Mild Cognitive Impairment
Assistive technology including virtual reality and augmented reality has gained interest as a novel intervention in a range of clinical settings. This technology has the potential to provide mental stimulation, a connection to autobiographical memory through reminiscence, and enhanced quality of life (QoL) to people living with dementia (PLWD) and mild cognitive impairment (MCI). In this mini-review, we examine the available evidence from studies reporting on the potential benefits of virtual and augmented reality to provide enjoyable, leisurely activities that may promote QoL and psychological well-being and facilitate so...
Source: Gerontology - May 20, 2019 Category: Geriatrics Source Type: research

New Trend in Old-Age Mortality: Gompertzialization of Mortality Trajectory
There is great interest among gerontologists, demographers, and actuaries in the question concerning the limits to human longevity. Attempts at getting answers to this important question have stimulated many studies on late-life mortality trajectories, often with opposing conclusions. One group of researchers believes that mortality stops growing with age at extreme old ages, and that hence there is no fixed limit to the human life span. Other studies found that mortality continues to grow with age up to extreme old ages. Our study suggests a possible solution to this controversy. We found that mortality deceleration is be...
Source: Gerontology - May 20, 2019 Category: Geriatrics Source Type: research

Low-Intensity Exercise Suppresses CCAAT/Enhancer-Binding Protein δ/Myostatin Pathway Through Androgen Receptor in Muscle Cells
Conclusions: Muscle AR expression and androgen production were increased by exercise and EPS treatment. As a mechanistical insight, it is suggested that AR inhibited myostatin expression transcriptionally by C/EBP δ suppression, which negatively influences IL-6/pSTAT3 expression and consequently contributes to the prevention of muscle proteolysis during exercise.Gerontology (Source: Gerontology)
Source: Gerontology - May 17, 2019 Category: Geriatrics Source Type: research

Effects of Age on Obstacle Avoidance while Walking and Deciphering Text versus Audio Phone Messages
Conclusions: Results suggest that coping with text messages while walking leads to greater risk of collision and alters message deciphering accuracy, while audio messages stand out as a safer and more efficient alternative for on-the-go communication. In general, older adults experienced larger motor-cognitive interference than younger adults, resulting in reduced AMR and more collisions without further changes in gait adaptation. Consequently, older adults failed to prioritize their safety when attending to phone messages while walking.Gerontology (Source: Gerontology)
Source: Gerontology - May 14, 2019 Category: Geriatrics Source Type: research

Examining Relationships between Multiple Self-Reported Sleep Measures and Gait Domains in Cognitively Healthy Older Adults
Conclusions: Among cognitively healthy older adults,sleep quality and daytime sleepiness, but not sleep-related distress, are associated with aspects of gait. Patients who report these symptoms should be assessed and monitored for possible changes in gait.Gerontology (Source: Gerontology)
Source: Gerontology - May 9, 2019 Category: Geriatrics Source Type: research

Prediction Model of Cardiac Risk for Dental Extraction in Elderly Patients with Cardiovascular Diseases
Conclusion: The RF-based prediction model is expected to be applicable for preoperative clinical assessment for preventing cardiac complications in elderly patients with CVDs undergoing dental extraction. The findings may aid physicians and dentists in making more informed recommendations to prevent cardiac complications in this patient population.Gerontology (Source: Gerontology)
Source: Gerontology - May 5, 2019 Category: Geriatrics Source Type: research

Human Inflammaging
Human aging is a very complex process that occurs in an intricate biological and physiological setting. Many changes occur with aging and among the most important are changes in immune reactivity associated with cell differentiation stages and the phenomenon of inflammaging, understood as subclinical inflammatory readiness, manifested by elevated levels of proinflammatory factors. It was stated for a long time that this tandem occurs in parallel or eventually sequentially. However, recent evidence points to the fact that, as both originate from chronic antigen stimulation, they mutually drive each other. In this context, i...
Source: Gerontology - May 5, 2019 Category: Geriatrics Source Type: research

Effect of Creative Dance on Fitness, Functional Balance, and Mobility Control in the Elderly
Conclusion: CD and stretching may both benefit fitness and balance for older adults; however, CD may improve dynamic balance and mobility more than stretching. Therefore, CD may be a creative physical activity that contributes to successful aging.Gerontology (Source: Gerontology)
Source: Gerontology - May 5, 2019 Category: Geriatrics Source Type: research

Implementing Accessibility Settings in Touchscreen Apps for People Living with Dementia
Conclusions: This study represents the first implementation of accessibility settings for dementia in mainstream apps, whilst demonstrating the feasibility and positive impact of the approach. The findings reveal core principles of touchscreen interaction and design for dementia that can inform future app development.Gerontology (Source: Gerontology)
Source: Gerontology - April 24, 2019 Category: Geriatrics Source Type: research

Epigenetic Mechanisms Underlying the Aging of Articular Cartilage and Osteoarthritis
Aging is a progressive and complicated bioprocess with overall decline in physiological function. Osteoarthritis (OA) is the most common joint disease in middle-aged and older populations. Since the prevalence of OA increases with age and breakdown of articular cartilage is its major hallmark, OA has long been thought of as “wear and tear” of joint cartilage. Nevertheless, recent studies have revealed that changes in the chondrocyte function and matrix components may reduce the material properties of articular cartilage and predispose the joint to OA. The aberrant gene expression in aging articular cartilage th...
Source: Gerontology - April 15, 2019 Category: Geriatrics Source Type: research

Erratum
Gerontology 2019;65:1 (Source: Gerontology)
Source: Gerontology - April 15, 2019 Category: Geriatrics Source Type: research

Pathophysiology of Benign Prostatic Hyperplasia and Benign Prostatic Enlargement: A Mini-Review
Benign prostatic hyperplasia (BPH), benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) belong to the most frequent diseases in ageing men. Beyond the 6th decade of life, more than 30% of men suffer from moderate to severe LUTS requiring intervention. The pathophysiology of BPH/BPE is still incompletely understood. The dominant role of the androgen system and the androgen receptor is well defined. Androgen receptors are expressed in BPH tissue in which they are activated by the potent androgen dihydrotestosterone. Synthesis of dihydrotestosterone is under control of the 5 α-reductase enzyme, ac...
Source: Gerontology - April 3, 2019 Category: Geriatrics Source Type: research

Physical Activity and Mobility Differentially Predict Nondemented Executive Function Trajectories: Do Sex and < b > < i > APOE < /i > < /b > Moderate These Associations?
Conclusions: Longitudinal analyses across a broad band of aging show that sex moderates the effects of both EPA and mobility on EF performance and change. Notably, this moderation occurs differentially across the AD genetic risk status. These results point to a precision health approach to observational and interventional research in which effects of physical activity and mobility on EF trajectories and dementia are examined in the personalized and interactive context of sex and AD risk.Gerontology (Source: Gerontology)
Source: Gerontology - March 31, 2019 Category: Geriatrics Source Type: research

Association between Adverse Childhood Experiences and Muscle Strength in Older Age
Conclusions: ACE are associated with later-life muscle weakness among women. These associations were not compensated by the adoption of healthy behaviors or an improvement in socioeconomic circumstances in adulthood. These results suggest that tackling these early-life risk factors in women could promote long-term grip strength, a biomarker of aging.Gerontology (Source: Gerontology)
Source: Gerontology - March 31, 2019 Category: Geriatrics Source Type: research

Oral Health and Cognitive Function in Older Adults: A Systematic Review
Conclusions: This systematic review provides evidence of an association between learning and memory, complex attention, and executive function with oral health in old age. Gaining a detailed picture of how specific types of cognitive decline relate to oral health has potential implications for earlier identification of older adults who experience oral health problems, and may also inform the development of more effective interventions focused on enhancing oral health outcomes in this group.Gerontology (Source: Gerontology)
Source: Gerontology - March 22, 2019 Category: Geriatrics Source Type: research

Cell Therapy for Knee Osteoarthritis: Mesenchymal Stromal Cells
Osteoarthritis (OA) is designated the 11th highest contributor of 291 diseases of global disability and the most common cause of chronic disability in elderly people. OA has a devastating impact on quality of life and represents an enormous socio-economic burden. Currently, OA is incurable, and no approved medications, biological therapy, or procedure prevents the progressive destruction of the osteoarthritic knee joint. All current treatments provide symptomatic relief rather than preventative or regenerative results. There is an urgent and compelling need to find, validate, and test new biological therapeutics. Cell-base...
Source: Gerontology - March 22, 2019 Category: Geriatrics Source Type: research

Is Life Expectancy of French Women Going to Plateau and Oscillate?
Some authors have hypothesised that life expectancy at birth could reach 100 years in developed countries in the next decades. Using recent data for French women, it is shown that life expectancy changes from 1993 to 2016 are mainly linked to mortality rates of oldest women. In recent years, it happened that life expectancy of French women oscillated, because of for instance influenza epidemics killing mainly oldest frail people. It is hypothesised that in coming years, life expectancy of French women (and one day of men?) will only very slightly increase and will show oscillations because of increased mortality the years ...
Source: Gerontology - March 21, 2019 Category: Geriatrics Source Type: research

Myostatin: A Powerful Biomarker for Sarcopenia and Frailty?
Gerontology (Source: Gerontology)
Source: Gerontology - March 14, 2019 Category: Geriatrics Source Type: research

Loneliness Shapes the Relationship between Information and Communications Technology Use and Psychological Adjustment among Older Adults
Conclusion: These findings suggest that ICT use may be a mixed blessing for older adults, i.e., using more ICT might predict worse psychological adjustment among lonelier older adults. Efforts that promote ICT use among older adults should take their loneliness levels into account.Gerontology (Source: Gerontology)
Source: Gerontology - March 7, 2019 Category: Geriatrics Source Type: research

Myostatin as a Biomarker for Diagnosis or Prognosis of Frailty and Sarcopenia: Current Knowledge
Gerontology (Source: Gerontology)
Source: Gerontology - March 7, 2019 Category: Geriatrics Source Type: research

Iridescent Life Course: LGBTQ Aging Research and Blueprint for the Future – A Systematic Review
Conclusions: The Iridescent Life Course framework highlights the interplay of light and environment, creating dynamic and fluid colors as perceived from different angles and perspectives over time. Such an approach incorporates bothqueering andtrans-forming the life course, capturing intersectionality, fluidity over time, and the psychological, behavioral, and biological as well as social dimensions of LGBTQ aging. Work is needed that investigates trauma, differing configurations of risks and resources over the life course, inequities and opportunities in representation and capital as LGBTQ adults age, and greater attentio...
Source: Gerontology - March 7, 2019 Category: Geriatrics Source Type: research

Identifying Features that Enhance Older Adults ’ Acceptance of Robots: A Mixed Methods Study
Conclusion: This study identified older adults ’ preference toward more functional and humanlike robots. Our findings provide practical suggestions for future robot designs that target the older population.Gerontology (Source: Gerontology)
Source: Gerontology - March 7, 2019 Category: Geriatrics Source Type: research

Performance of E-Health Devices for Frailty Evaluation in Real-Life Settings Is Far from Being Demonstrated
Gerontology (Source: Gerontology)
Source: Gerontology - February 18, 2019 Category: Geriatrics Source Type: research

Is the Effect of Physical Activity on Quality of Life in Older Adults Mediated by Social Support?
Increasing evidence suggests positive associations between physical activity, social support, and quality of life in later life. However, the role of physical activity and social support in the influence on quality of life is unclear. In this viewpoint, definitions of central terms and key research findings on factors influencing quality of life in older adults are provided. We highlight the importance of both a physically active lifestyle and high social support in positively influencing quality of life. However, we question the direct effect of physical activity on quality of life and present data of a cross-sectional st...
Source: Gerontology - February 14, 2019 Category: Geriatrics Source Type: research

Behaviors and Strategies Supporting Everyday Memory in Older Adults
Conclusions: Older adults ’ reported everyday memory failures were linked to suboptimal use of external memory aids and to a reliance on incidental learning and remembering. There is potential value for interventions that improve procedures for managing everyday life goals that rely on memory.Gerontology (Source: Gerontology)
Source: Gerontology - February 8, 2019 Category: Geriatrics Source Type: research

Pillars of Successful Research: Serendipity, Pasteur ’s Axiom, Kairos, and Luck
Gerontology (Source: Gerontology)
Source: Gerontology - February 8, 2019 Category: Geriatrics Source Type: research

Development of a Home Health Patient Assessment Tool for Disaster Planning
Conclusion: Home-based care programs, such as the VHA HBPC program, are tasked with supporting the emergency preparedness of their patients, but often do not have the expertise to do so. This study shows that the checklist-like structure of an assessment tool can assist with this role by encouraging practitioners to cover key points with patients and their caregivers.Gerontology (Source: Gerontology)
Source: Gerontology - February 7, 2019 Category: Geriatrics Source Type: research

Hard Tissue Augmentation of Aged Bone by Means of a Tin-Free PLLA-PCL Co-Polymer Exhibiting in vivo Anergy and Long-Term Structural Stability
Conclusion: Given the long-term shape stability in vivo, featuring imperceptible degradation and little scarring as well as exerting good compatibility to cells and surrounding tissues, this novel biomaterial is suitable as a space filler in large anatomical defects.Gerontology (Source: Gerontology)
Source: Gerontology - January 27, 2019 Category: Geriatrics Source Type: research

Gait Test or No Gait Test: Do We Need Walking Assessment to Determine Physical Frailty?
Gerontology (Source: Gerontology)
Source: Gerontology - January 27, 2019 Category: Geriatrics Source Type: research

Office-Based Physical Assessment in Patients Aged 75 Years and Older with Cardiovascular Disease
Conclusion: Short OLST, in particular #x3c; 3 s, is associated with decreased physical performance and elevated mortality risk in elderly patients with cardiovascular disease. OLST can be conveniently measured in the clinician ’s office as a screening tool for impaired physical performance.Gerontology (Source: Gerontology)
Source: Gerontology - January 16, 2019 Category: Geriatrics Source Type: research

Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body Myositis
Conclusion: RE enhances mitochondrial function by improving MQC and mitochondrial oxidative capacity via reducing A β accumulation, thereby inhibiting CQ-induced muscle impairment, in a rat model of s-IBM.Gerontology (Source: Gerontology)
Source: Gerontology - January 14, 2019 Category: Geriatrics Source Type: research

Divergence and Convergence: How Do Income Inequalities in Mortality Change over the Life Course?
Conclusion: The results for absolute and relative measures of inequality differed substantially; this highlights the importance of discussing and making an active choice of inequality measure. To explain and understand the patterns of inequality in mortality over the adult life course, we conclude that the “age-as-leveler” and “cumulative disadvantage” theories are best applied to an absolute measure of inequality.Gerontology (Source: Gerontology)
Source: Gerontology - January 13, 2019 Category: Geriatrics Source Type: research

Social Loneliness after Divorce: Time-Dependent Differential Benefits of Personality, Multiple Important Group Memberships, and Self-Continuity
Conclusions: Our findings demonstrate that the effects of psychological and social resources on social loneliness vary by adaptation phase. Although extroversion is beneficial for all divorced and married individuals, other personality traits play a more decisive role in the initial adaptation phase. Identity-promoting resources (i.e., multiple group memberships, perceived self-continuity) are beneficial only later in the adaptation process. To be successful, professional interventions must be tailored as needed.Gerontology (Source: Gerontology)
Source: Gerontology - January 3, 2019 Category: Geriatrics Source Type: research

Perception of Risk for Older Adults: Differences in Evaluations for Self versus Others and across Risk Domains
Conclusion: Family members, partners, and close friends are sensitive to vulnerabilities of their social partners, but in some domains and according to their partners ’ age they perceive a greater (or smaller) risk than their partners perceive for themselves. In situations requiring surrogate decision-making, people may decide differently from how their social partners would decide for themselves.Gerontology (Source: Gerontology)
Source: Gerontology - December 19, 2018 Category: Geriatrics Source Type: research

Changes in and Interactions between Physical and Mental Health in Older Japanese: The Nakanojo Study
Conclusion: Functional capacity and mood state are interrelated. Greater function could sustain vitality and mental health, possibly reducing anxiety and depression.Gerontology (Source: Gerontology)
Source: Gerontology - December 19, 2018 Category: Geriatrics Source Type: research

CD33 in Alzheimer ’s Disease – Biology, Pathogenesis, and Therapeutics: A Mini-Review
Alzheimer ’s disease (AD) affects nearly 50 million people worldwide, and currently no disease-modifying treatment is available. With continuous failure of anti-amyloid-beta- or tau-based therapies, identification of new targets has become an urgent necessity for AD prevention and therapy. Recently, convent ional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of AD. A number of genes have been highly linked to the onset and development of late-onset sporadic AD, the most common form of AD. Strikingly, most of these genes are involved in...
Source: Gerontology - December 14, 2018 Category: Geriatrics Source Type: research

How to Measure Population Aging? The Answer Is Less than Obvious: A Review
Usually, population aging is measured to inform fiscal and social planning because it is considered to indicate the burden that an elderly population presents to the economic, social security, and health systems of a society. Measures of population aging are expected to indicate shifts in the distribution of individuals ’ attributes (e.g., chronological age, health) within a population that are relevant to assessing the burden. We claim that chronological age – even though it is the attribute most broadly used – may frequently not be the best measure to satisfy this purpose. A distribution of chronologica...
Source: Gerontology - December 14, 2018 Category: Geriatrics Source Type: research

Effectiveness of Daily Use of Bilateral Custom-Made Ankle-Foot Orthoses on Balance, Fear of Falling, and Physical Activity in Older Adults: A Randomized Controlled Trial
Conclusion: Results suggest that bilateral custom-made AFO plus walking shoes is effective in improving balance compared to walking shoes alone, and it significantly reduces the fear of falling, with a nonsignificant but noticeable positive trend in physical activity, compared to baseline. The results also suggest that older adults with poor balance at baseline and higher daily adherence to using the AFO will gain more benefit from the AFO intervention.Gerontology (Source: Gerontology)
Source: Gerontology - November 30, 2018 Category: Geriatrics Source Type: research

Marital Transitions and Depressive Symptoms among Older Adults: Examining Educational Differences
Conclusions: Our findings revealed a predictable educational gradient for the occurrence of marital transitions and later-life mental health. Yet higher, formalized education did not protect the participants from increased depression in the presence of a loss-related transition, which could suggest that the strains of spousal loss may to some degree function as a leveler of the preexisting social inequalities of stratified life courses. We conclude that the benefits conferred by education are not necessarily ubiquitous, and its impact on the adaptation to spousal loss may be more complex and nuanced depending on the range ...
Source: Gerontology - November 27, 2018 Category: Geriatrics Source Type: research

Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention
Conclusions: Higher serum levels of myostatin were found to be associated with better physical fitness. The improvements in physical fitness after the intervention were positively related to increases in myostatin concentrations in men. These results seem to rule out the idea that high serum myostatin levels are indicative of frailty in long-term nursing home residents. However, although the direction of association was opposite to that expected for the function of myostatin, the use of this protein as a biomarker for physical fitness, rather than frailty, merits further study.Gerontology (Source: Gerontology)
Source: Gerontology - November 21, 2018 Category: Geriatrics Source Type: research

Vastly Different Exercise Programs Similarly Improve Parkinsonian Symptoms: A Randomized Clinical Trial
Conclusion: Two highly different exercise programs resulted in similar improvement of most motor and clinical symptoms in PD patients.Gerontology (Source: Gerontology)
Source: Gerontology - October 26, 2018 Category: Geriatrics Source Type: research

STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases
Conclusion: Our results indicate that decreased sensitivity of the innate immune receptors is associated with healthy aging, most likely due to a decreased process of inflamm-aging.Gerontology (Source: Gerontology)
Source: Gerontology - October 26, 2018 Category: Geriatrics Source Type: research

Instrumented Trail-Making Task: Application of Wearable Sensor to Determine Physical Frailty Phenotypes
Conclusion: This study demonstrated a non-gait-based wearable platform to objectively quantify frailty phenotypes and determine physical frailty, using a quick and practical test. This platform may address the hurdles of conventional physical frailty phenotypes methods by replacing the conventional frailty walking test with an automated and objective process that reduces the time of assessment and is more practical for those with mobility limitations.Gerontology (Source: Gerontology)
Source: Gerontology - October 25, 2018 Category: Geriatrics Source Type: research

Beam Walking to Assess Dynamic Balance in Health and Disease: A Protocol for the “BEAM” Multicenter Observational Study
Conclusion: We expect to find that beam walking performance vis- à-vis the traditionally used balance outcomes predicts more accurately fall risks and falls.Clinical Trial Registration Number: NCT03532984.Gerontology (Source: Gerontology)
Source: Gerontology - October 18, 2018 Category: Geriatrics Source Type: research

Contents Vol. 64, 2018
Gerontology 2018;64:I –VI (Source: Gerontology)
Source: Gerontology - October 16, 2018 Category: Geriatrics Source Type: research