Immune Profile and Body Composition of Independent Oldest Old: The Longevous Project
Conclusion: In the independent oldest old, IRP rate proved low and high-sensitivity CRP was shown to be associated with body composition.Gerontology (Source: Gerontology)
Source: Gerontology - January 19, 2023 Category: Geriatrics Source Type: research
Effects of Cognitive Training in Flanker Task on Mobility of Older Adults: A Randomized Controlled Trail
Introduction: Cognitive function is considered to be correlated with the older adults ’ mobility. Flanker task, reflecting the conflict resolution, is barely explored as a simple approach to train the elderly’s cognitive function. Hence, the first aim of this study is to explore the effect of cognitive intervention adopting flanker task on mobility. The second aim of this study i s to assess the effect of cognitive training by comparing it with physical training to disclose how much dosage of cognitive training can have the equal improvement of mobility with physical training.
Methods: 232 older adults (age, mean ± S...
Source: Gerontology - January 16, 2023 Category: Geriatrics Source Type: research
Dual-Task Upper Extremity Motor Performance Measured by Video Processing as Cognitive-Motor Markers for Older Adults
Conclusion: This study proposes a video processing-based approach to analyze dual-task upper-extremity motor performance from a simple and convenient upper-extremity function test. The results indicate concurrent validity of the proposed video-based MCM compared with the sensor-based MCM, and associations between dual-task upper-extremity motor performance and clinically validated cog nitive markers (MMSE scores and dual-task gait). Future studies are warranted to explore sensitivity of this solution to promote remote assessment of cognitive-motor performance among older adults in telehealth applications. (Source: Gerontology)
Source: Gerontology - January 13, 2023 Category: Geriatrics Source Type: research
The Dynamic Interplay of Objective and Subjective Balance and Subsequent Task Performance: Implications for Fall Risk in Older Adults
Conclusion. Findings indicate that older adults, especially those with higher fall risk, may be unaware of subtle fluctuations in balance, which could lead to engaging in activities that exceed the capacity to maintain balance at that moment. Fall prevention efforts should address older adults ’ understanding of and responses to fluctuations of physical function in daily life. (Source: Gerontology)
Source: Gerontology - January 13, 2023 Category: Geriatrics Source Type: research
National Weekly SARS-CoV-2 RT-PCR Screening of All Workers in Long-Term Care Facilities Associated with Decrease in Resident Mortality Rate
This study examines whether routine screening tests carried out on health care workers can help in reducing COVID-19 outbreaks, morbidity, and mortality of LTCF residents.
Methods
The study followed a weekly, nationwide, government-funded screening program of LTCF personnel for SARS-CoV-2, by using reverse transcription polymerase chain reaction as the main testing technology. It included all residents and employees in Israeli LTCFs who were screened weekly during the second wave of COVID-19, during the time period between July 13, 2020, and November 21, 2020.
Results
During the study period, 1,107 LTCFs were screened ...
Source: Gerontology - January 11, 2023 Category: Geriatrics Source Type: research
Why is rapamycin not a rapalog?
Rapamycin (sirolimus) is an immunosuppressive drug approved by the Food and Drug Administration (FDA). It is also a leading candidate for targeting aging. Rapamycin and its analogs (everolimus, temsirolimus, ridaforolimus) inhibit the mammalian target of rapamycin (mTOR) kinase by binding to FK506-binding proteins (FKBP) and have a similar chemical structure that only differs in the functional group present at carbon-40. Analogs of rapamycin were developed to improve its pharmacological properties, such as low oral bioavailability and a long half-life. The analogs of rapamycin are referred to as 'rapalogs.' Rapamycin is th...
Source: Gerontology - January 7, 2023 Category: Geriatrics Source Type: research
The association between frailty and dementia-free and physical disability-free survival in community-dwelling older adults
Conclusion: Our study showed that pre-frailty is common in community-dwelling older adults initially free of cardiovascular disease, dementia or independence-limiting physical disability. Pre-frailty and f railty significantly reduced disability-free survival. Addressing modifiable correlates, like depression and polypharmacy, might reduce the adverse impact of frailty on dementia-free and physical disability-free survival. (Source: Gerontology)
Source: Gerontology - January 7, 2023 Category: Geriatrics Source Type: research
Associations of Inflammatory, Metabolic, Malnutrition, and Frailty Indexes with Multimorbidity Incidence and Progression, and Mortality Impact: Singapore Longitudinal Aging Study
Conclusion: The onset and progression of multimorbidity and its mortality impact are driven by systemic factors, including inflammation, metabolic dysfunction (insulin resistance), malnutrition, and frailty. The measurement of these systemic factors using simple, inexpensive clinical and blood chemistry tools can help in strategies to prevent and reduce its mortality impact.Gerontology (Source: Gerontology)
Source: Gerontology - January 6, 2023 Category: Geriatrics Source Type: research
An Exergame-Integrated IoT-Based Ergometer System Delivers Personalized Training Programs for Older Adults and Enhances Physical Fitness: A Pilot Randomized Controlled Trial
Conclusions: EIoT-ergo was developed to provide personal identification, exergames, intelligent exercise prescriptions, and remote monitoring, as well as to significantly enhance the physical fitness of the elderly individuals under study.Gerontology (Source: Gerontology)
Source: Gerontology - January 6, 2023 Category: Geriatrics Source Type: research
Lactate Dehydrogenase Predicts Hemorrhagic Transformation in Patients with Acute Ischemic Stroke
This study aimed to evaluate the relationship between serum LDH levels and HT.
Methods: We retrospectively included 542 AIS patients with HT and 1091 age and gender-matched patients without HT. Demographic and clinical data were obtained from medical records, and blood samples were obtained within 24 hours after admission. The characteristics of groups were compared. With the receiver operating characteristic curve (ROC) analysis, we assessed the discriminating capacity of LDH levels in predicting HT in patients with AIS. The logistic regression model was used to determine the connection between LDH and HT.
Results: The ...
Source: Gerontology - January 5, 2023 Category: Geriatrics Source Type: research
Dose-Dependent Association Between Sarcopenia and Moderate-to-Severe Thoracic Vertebral Fragility Fracture in Older Adults
Introduction
Sarcopenia and vertebral fracture affect a large number of older adults and can be debilitating. However, the correlation between sarcopenia and vertebral fracture has not been well studied. Thus, this study investigates the correlation between vertebral fragility fracture and the severity of sarcopenia.
Method
This cross-sectional study included 300 community-dwelling older adults with risk higher than 10-year probability of 3% for a hip fracture and 20% for a major osteoporotic fracture by FRAX score. Sarcopenia was defined according to the Asian Working Group for Sarcopenia consensus. Bone mineral densit...
Source: Gerontology - January 2, 2023 Category: Geriatrics Source Type: research
Subjective Health and Physical-Activity Engagement across Adulthood: Distinguishing between Within-Person and Between-Person Associations
This study revealed various associations between subjective health and engagement in physical activity across levels (the within- vs. between-person level) and across age groups (younger vs. older group). The finding contributes to a better understanding of people ’s health behavior in reaction to health decline at different ages. It also supports the proposition that age-related intraindividual increases in losses (e.g., health decline) motivate behaviors that counteract such losses (e.g., physical activity that protects health).Gerontology (Source: Gerontology)
Source: Gerontology - January 2, 2023 Category: Geriatrics Source Type: research
A cross-sectional analysis of receptor for advanced glycation end-products in human skeletal muscle: a comparative analysis between patients with and without sarcopenia
Introduction Animal studies suggest that advanced glycation end-products (AGEs) and their interaction with receptor for AGEs (RAGE) are involved in sarcopenia, but their relationship in human skeletal muscles has yet to be elucidated. We aimed to determine whether RAGE expression in human skeletal muscle is associated with serum AGE levels and sarcopenia-related changes.
Methods We retrospectively reviewed 33 consecutive women (mean age, 65 years) with distal radius fracture who had consented to donate a sample of forearm muscle for research purposes, which was taken during surgical fracture repair. The muscle RAGE expres...
Source: Gerontology - December 30, 2022 Category: Geriatrics Source Type: research
Information and Communication Technology Use for Alleviation of Disability Onset in Socially Isolated Older Adults: A Longitudinal Cohort Study
This study aimed to investigate whether ICT use could alleviate the onset of disability in community-dwelling older adults with and without social isolation.
Methods: This longitudinal cohort study on 4,346 community-dwelling independent Japanese older adults (mean age, 73.5 ±5.3 years) was conducted between 2017 and 2018. Participants were classified into four groups based on social isolation (the condition where two or more of the following measures were met: domestic isolation, less social contact, and social disengagement) and ICT users (those who had recently used a computer or a smartphone) and followed up to asses...
Source: Gerontology - December 30, 2022 Category: Geriatrics Source Type: research
Exergame-assisted rehabilitation for preventing falls in older adults at risk: A systematic review and meta-analysis
Introduction. Exergaming is increasingly employed in rehabilitation for older adults. However, their effects on fall rate and fall risk remain unclear. Methods. We conducted a systematic review and meta-analysis that included randomized controlled trials (RCTs) comparing exergame-assisted rehabilitation with control groups, published in French or English, from Web of Science, CINHAL, Embase, Medline and CENTRAL (last search in June 2021). Two reviewers independently assessed studies. Risk of bias was assessed using RoB2, PEDRO scale and the GRADE system. The outcomes of interest were: a) Fall rate, b) Risk of falling, meas...
Source: Gerontology - December 29, 2022 Category: Geriatrics Source Type: research
